Zobrazeno 1 - 10 of 17 pro vyhledávání: '"D. T. W. CHU"'
1
Type II DNA Topoisomerases as Antibacterial Targets
Autor: L. L. Shen, D. T. W. Chu
Publikováno v: Current Pharmaceutical Design. 2:195-208
DNA topoisomerases are a class of ubiquitous enzymes that maintain the topological structures of DNA in both prokaryotic and eukaryotic organisms. The enzymes catalyze DNA topoisomerization reactions through a sequential DNA breaking­ passing-reseal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce6f90d3cf8f5c4a52d884936e71198c
https://doi.org/10.2174/1381612802666220921174531
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2
In vitro and in vivo evaluations of A-80556, a new fluoroquinolone
Autor: J. J. Clement, D. T. W. Chu, D. Hensey, J M Beyer, D. Mcdaniel, N. Ramer, C. Vojtko, J. Alder, S. K. Tanaka
Publikováno v: Antimicrobial Agents and Chemotherapy. 38:1071-1078
A-80556 is a novel fluoroquinolone with potent antibacterial activity against gram-positive, gram-negative, and anaerobic organisms. A-80556 was more active than ciprofloxacin, ofloxacin, lomefloxacin, and sparfloxacin against gram-positive bacteria.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8a2576ac4301df6fad777808f18491
https://doi.org/10.1128/aac.38.5.1071
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5
Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282
Autor: N. Wideburg, D. Weigl, William E. Kohlbrenner, Ayda Saldivar, D. T. W. Chu
Publikováno v: Antimicrobial Agents and Chemotherapy. 36:81-86
A number of quinolones and related antibacterial compounds were screened for activity against calf thymus topoisomerase II by using the P4 unknotting and DNA breakage assays. Several compounds from different structural classes which inhibited DNA unk
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9f3f790fd3233b3e9531fba5577351
https://doi.org/10.1128/aac.36.1.81
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6
Activity of temafloxacin against respiratory pathogens
Autor: D. T. W. Chu, Nathan L. Shipkowitz, R N Swanson, J J Clement, Dwight J. Hardy
Publikováno v: Antimicrobial Agents and Chemotherapy. 35:423-429
The activity of the quinolone temafloxacin against respiratory pathogens was compared with those of ciprofloxacin and ofloxacin. MICs for 90% of strains tested indicated that temafloxacin was at least two- to fourfold more potent than the other two q
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593f772a940dfa279872c1ecfee34f2e
https://doi.org/10.1128/aac.35.3.423
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7
In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor
Autor: D. T. W. Chu, Q. Li, D. Hensey, J. Beyer, J. J. Clement, C. Vojtko, Robert K. Flamm, S. K. Tanaka, Nancy C. Ramer
ABT-719 (A-86719.1) is the first compound of a new class of novel DNA gyrase inhibitors, the 2-pyridones, with potent antibacterial activity against gram-positive, gram-negative, and anaerobic organisms. ABT-719 was more active than ciprofloxacin, sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5070fe276e55bf7da45c1eb1228614
https://europepmc.org/articles/PMC162662/
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8
Quinolone-DNA Interaction: How a Small Drug Molecule Acquires High DNA Binding Affinity and Specificity
Autor: L. L. Shen, J. J. Plattner, D. T. W. Chu, M. G. Bures
Publikováno v: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ISBN: 9789401056571
Quinolones are a group of low molecular-weight, synthetic and extremely potent antibacterial agents. The functional target of these drugs have been shown to be the bacteria-specific DNA gyrase, a type II DNA topoisomerase. Quinolones may be classifie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8662001e38918a64e3fb8d6eab6839f3
https://doi.org/10.1007/978-94-011-3728-7_32
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10
A-61827 (A-60969), a new fluoronaphthyridine with activity against both aerobic and anaerobic bacteria
Autor: C. W. Hanson, D. T. W. Chu, N. R. Ramer, Robert R. Bower, R N Swanson, P B Fernandes, John M. Stamm, Dwight J. Hardy
Publikováno v: Antimicrobial Agents and Chemotherapy. 32:27-32
A-61827 (A-60969 is the hydrochloric salt of A-61827) is a new aryl-fluoronaphthyridine which is active against aerobic and anaerobic bacteria. The MICs of A-61827 for 90% of strains (MIC90) of staphylococci and streptococci were less than or equal t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825659a07fc9f929a602a953ed95e74a
https://doi.org/10.1128/aac.32.1.27
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