Zobrazeno 1 - 8
of 8
pro vyhledávání: '"D. T. Newgreen"'
Autor:
Gillian Edwards, K.M. Bray, T.J. Brown, D. T. Newgreen, Arthur H. Weston, J. Longmore, Susan Duty
Publikováno v:
British Journal of Pharmacology. 102:337-344
1. The effects of cromakalim on endothelium-denuded rabbit aortic strips were compared with those of the calcium (Ca2+) entry blocking agent, nifedipine. 2. Pre-incubation with cromakalim or nifedipine had no significant effect on the initial phasic
Autor:
J. Longmore, B. S. Brown, Susan Duty, D. T. Newgreen, P. B. Kay, A. D. McHarg, Arthur H. Weston, K.M. Bray, Gillian Edwards, J. S. Southerton
Publikováno v:
British Journal of Pharmacology. 100:605-613
1. The actions of diazoxide and minoxidil sulphate have been compared with those of cromakalim in rat aorta and portal vein. 2. Diazoxide and minoxidil sulphate hyperpolarized the rat portal vein in a similar manner to cromakalim. 3. Cromakalim, diaz
Publikováno v:
Journal of Vascular Research. 27:306-313
Cromakalim, pinacidil, nicorandil, diazoxide and RP- 49356 belong to the class of drugs termed potassium channel openers. In rat portal vein diazoxide, like cromakalim, abolished spontaneous mechanical and electrical activity and in rat aorta caused
Autor:
Roger C. Small, Sheila W. Weir, Arthur H. Weston, K.M. Bray, S.G. Taylor, D. T. Newgreen, J. S. Southerton
Publikováno v:
British Journal of Pharmacology. 91:421-429
The effects of pinacidil have been compared with those of glyceryl trinitrate (GTN) using the aorta and portal vein of the rat and the trachealis and taenia caeci of the guinea-pig. In aorta, both pinacidil and GTN inhibited responses to noradrenalin
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 338(3)
In rat aorta and rat portal vein, (-)- and (+)-pinacidil each produced a concentration-dependent inhibition of tension development. Although the (-) isomer was the more potent, concentration effect curves for each isomer were steep with similar slope
Publikováno v:
Journal of cardiovascular pharmacology. 12
In rat portal vein and aorta, pinacidil (0.3-100 microM) inhibited spontaneous mechanical activity (portal vein) and responses to norepinephrine (0.001-100 microM) and to KCl (5-80 mM). Pinacidil and its analogs P1060 and P1368 inhibited established
Publikováno v:
British journal of pharmacology.
Publikováno v:
Drugs. 36
(+/-) Pinacidil inhibited noradrenaline-induced contractions in rat aorta and portal vein. The spontaneous tone of guinea-pig bronchial and taenia caeci muscles was relaxed and the spontaneous mechanical activity of rat portal vein was abolished. (+/