Zobrazeno 1 - 10
of 15
pro vyhledávání: '"D. T. Beattie"'
Autor:
J A M Smith, Patrick P.A. Humphrey, D T Beattie, N Mai, M D O'Keefe, R G Vickery, M. Teresa Pulido-Rios, E Kaufman
Publikováno v:
British Journal of Pharmacology. 150:782-791
Background and purpose: 5-HT4 receptor agonists are used therapeutically to treat disorders of reduced gastrointestinal motility. Since such compounds are evaluated in guinea-pigs, we cloned, expressed and pharmacologically characterized the guinea-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f9af4043e1d1937e51133ed44edba21
https://doi.org/10.1038/sj.bjp.0707154
https://doi.org/10.1038/sj.bjp.0707154
Publikováno v:
Pharmacological Research. 53:353-358
The 5-HT 4 receptor agonist and gastroprokinetic, tegaserod, possesses 5-HT 2B receptor antagonist activity. However, the relevance of such activity is unclear. In this study, the 5-HT 2B receptor antagonist and 5-HT 4 agonist activities of tegaserod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943b3a62ca549d33ec3581343f9ed016
https://doi.org/10.1016/j.phrs.2006.01.003
https://doi.org/10.1016/j.phrs.2006.01.003
Autor:
R G Vickery, J A M Smith, M. Teresa Pulido-Rios, S.R. Armstrong, N Mai, Patrick P.A. Humphrey, C. Sandlund, D T Beattie, J.L. McCullough, C Richardson, D. Marquess
Publikováno v:
British Journal of Pharmacology. 143:549-560
Tegaserod (Zelnorm®) is a potent 5-hydroxytryptamine4 (5-HT4) receptor agonist with clinical efficacy in disorders associated with reduced gastrointestinal motility and transit. The present study investigated the interaction of tegaserod with 5-HT2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e64e3cfda36b8bb56bf1302f77a5c79
https://doi.org/10.1038/sj.bjp.0705929
https://doi.org/10.1038/sj.bjp.0705929
Autor:
Y.-P. Li, M. Kitt, John F. Johanson, O. Daniels, D. T. Beattie, Allen W. Mangel, M. Goldberg, Kathryn Kersey
Publikováno v:
Alimentary pharmacologytherapeutics. 32(9)
Aliment Pharmacol Ther 2010; 32: 1102–1112 Summary Background Velusetrag is an orally active 5-HT4 receptor agonist of potential benefit in treating chronic idiopathic constipation. Aim To evaluate the efficacy, safety and tolerability of velusetra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67be17884b05020c833d19693fe7302
https://pubmed.ncbi.nlm.nih.gov/21155854
https://pubmed.ncbi.nlm.nih.gov/21155854
Autor:
W. Feniuk, David I. C. Scopes, A.W. Oxford, W. L. Mitchell, Guy A. Higgins, H. A. Kelly, M. Skingle, M.B. Tyers, I. B. Campbell, C. C. Jordan, Alan H. Wadsworth, M. C. Carter, J. W. Clitherow, Eric W. Collington, Helen E. Connor, D. T. Beattie
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::530f04a40209f7748934390768bfb9ab
https://doi.org/10.1002/chin.199451138
https://doi.org/10.1002/chin.199451138
Publikováno v:
Journal of Bacteriology. 174:970-979
The products of the bvgAS locus coordinately regulate expression of the Bordetella pertussis virulence regulon in response to environmental signals. Transcription of bvgAS-activated genes is nearly eliminated by several modulating conditions, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc240c4c35be16e45603b7c11c61f5a8
https://doi.org/10.1128/jb.174.3.970-979.1992
https://doi.org/10.1128/jb.174.3.970-979.1992
Autor:
J. A. M. Smith, D. T. Beattie
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 377(3)
Serotonin (5-hydroxytryptamine or 5-HT) plays a critical physiological role in the regulation of gastrointestinal (GI) function. 5-HT dysfunction may also be involved in the pathophysiology of a number of functional GI disorders, such as chronic cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737c016df52bae845dbc2212fa27f298
https://pubmed.ncbi.nlm.nih.gov/18398601
https://pubmed.ncbi.nlm.nih.gov/18398601
Autor:
R G, Vickery, N, Mai, E, Kaufman, D T, Beattie, T, Pulido-Rios, M, O'Keefe, P P A, Humphrey, J A M, Smith
Publikováno v:
British journal of pharmacology. 150(6)
5-HT(4) receptor agonists are used therapeutically to treat disorders of reduced gastrointestinal motility. Since such compounds are evaluated in guinea-pigs, we cloned, expressed and pharmacologically characterized the guinea-pig 5-HT(4) and human 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6905f9b85ea7c76d4add482f3531b057
https://pubmed.ncbi.nlm.nih.gov/17293885
https://pubmed.ncbi.nlm.nih.gov/17293885
Autor:
N. Mai, Ross G. Vickery, D. T. Beattie, M. Cheruvu, C. Peterson, M. O’Keefe, E. Kaufman, S. Johnson-Rabidoux
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 375(3)
This study characterized the pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, its metabolite, ADL 08-0011, and methylnaltrexone. The activities of the compounds were investigated with respect to human or guinea pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ef7c686447db7c25f9c25862b2d940
https://pubmed.ncbi.nlm.nih.gov/17340127
https://pubmed.ncbi.nlm.nih.gov/17340127
Autor:
D T, Beattie, J A M, Smith, D, Marquess, R G, Vickery, S R, Armstrong, T, Pulido-Rios, J L, McCullough, C, Sandlund, C, Richardson, N, Mai, P P A, Humphrey
Publikováno v:
British journal of pharmacology. 143(5)
1 Tegaserod (Zelnorm) is a potent 5-hydroxytryptamine4 (5-HT4) receptor agonist with clinical efficacy in disorders associated with reduced gastrointestinal motility and transit. The present study investigated the interaction of tegaserod with 5-HT2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ce098e6e9ce764d80ec0fd8b7360426
https://pubmed.ncbi.nlm.nih.gov/15466450
https://pubmed.ncbi.nlm.nih.gov/15466450