A new species of Mycomya Rondani, 1856 (Diptera: Mycetophilidae) common to southeast Australia, Tasmania, and New Zealand

Autor: D. STEVEN KERR, SHAUN THOMPSON, PETER H. KERR

Publikováno v: Zootaxa. 5264:418-428

Mycomya quadrimaculata sp. nov. is described from specimens collected in southeast Australia, Tasmania, and New Zealand. A key and type photographs of known Australian and New Zealand Mycomya species are provided. The relative abundance, observed dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93b987b956f685fee888706246ba1fd
https://doi.org/10.11646/zootaxa.5264.3.9

GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain

Autor: Geeske M. van Woerden, Christian D. Kelstrup, Emma K. Gowing, Inge S. Villumsen, Anders B. Klein, Birgitte Rahbek Kornum, Christine L. Gee, Nane Griem-Krey, Mohamed A. Shehata, Ulrike Leurs, Rasmus P. Clausen, Stine J. Gauger, Andrew N. Clarkson, Louise Hamborg, Anne Sofie G. Larsen, Chris C. Chi, Robert O. Burnie, Anders Bach, D. Steven Kerr, Jesper V. Olsen, Sara Marie Øie Solbak, Petrine Wellendorph, John Kuriyan, Ethan D McSpadden, Josh Houlton, Stine B. Vogensen, Selina M. W. Teurlings, Bente Frølund, Line B. Palmelund

Publikováno v: Leurs, U, Klein, A B, McSpadden, E D, Griem-Krey, N, Solbak, S M O, Houlton, J, Villumsen, I S, Vogensen, S B, Hamborg, L, Gauger, S J, Palmelund, L B, Larsen, A S G, Shehata, M A, Kelstrup, C D, Olsen, J V, Bach, A, Burnie, R O, Kerr, D S, Gowing, E K, Teurlings, S M W, Chi, C C, Gee, C L, Frølund, B, Kornum, B R, van Woerden, G M, Clausen, R P, Kuriyan, J, Clarkson, A N & Wellendorph, P 2021, ' GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 31 . https://doi.org/10.1073/pnas.2108079118
Proceedings of the National Academy of Sciences of the United States of America, 118(31):e2108079118. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 31

Significance GHB is a natural brain metabolite of GABA, previously reported to be neuroprotective. However, the high-affinity binding site for GHB has remained elusive for almost 40 y. We here unveil CaMKIIα, a highly important neuronal kinase, as t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3968f82757f44ca335598be37cbc1e0
https://curis.ku.dk/portal/da/publications/ghb-analogs-confer-neuroprotection-through-specific-interaction-with-the-camkii-alpha-hub-domain(df178a50-331d-40f4-ae3d-8333cff82958).html

Functional preservation of hippocampal CA1 by low-dose GYKI-52466 preconditioning in a rat model of hypoxic-ischemic brain injury

Autor: Prasanta Kumar Nayak, D. Steven Kerr

Publikováno v: Brain Research. 1613:100-109

Global ischemia during cardiac surgery, brain surgery and stroke leads to lasting neuropsychological impairments. Previously we showed that low-dose GYKI-52466 preconditioning protects against kainic acid-induced seizures and unilateral hypoxic-ische

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5663745f4fce7346aec4b6e92ce5266c
https://doi.org/10.1016/j.brainres.2015.04.004

Neuromuscular blocking activity of pinnatoxins E, F and G

Autor: Andrew I. Selwood, Lesley M Rhodes, D. Steven Kerr, Shane D. Hellyer

Publikováno v: Toxicon. 76:214-220

Pinnatoxins are produced by dinoflagellates and belong to the cyclic imine family of toxins. They are fast-acting and highly toxic when administered in vivo in rodent bioassays, causing death by respiratory depression within minutes. Studies have rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa656c311686d85e6a6fe73924d59cf
https://doi.org/10.1016/j.toxicon.2013.10.009

Ischemic Cardiomyopathy Following Seizure Induction by Domoic Acid

Autor: Joanne C. Harrison, Alexandra Vranyac-Tramoundanas, Punam M. Sawant, Ivan A. Sammut, D. Steven Kerr

Publikováno v: The American Journal of Pathology. 179:141-154

Exposure to the excitotoxin domoic acid (DOM) has been shown to produce cardiac lesions in both clinical and animal studies. We have previously shown that DOM failed to directly affect cardiomyocyte viability and energetics, but the development of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583627e246884b995dba0a71496d54aa
https://doi.org/10.1016/j.ajpath.2011.03.017