Zobrazeno 1 - 10
of 703
pro vyhledávání: '"D. Spicer"'
Autor:
Parneet K. Cheema, Paul F. Wheatley-Price, Matthew J. Cecchini, Peter M. Ellis, Alexander V. Louie, Sara Moore, Brandon S. Sheffield, Jonathan D. Spicer, Patrick James Villeneuve, Natasha B. Leighl
Publikováno v:
Current Oncology, Vol 31, Iss 11, Pp 6979-6999 (2024)
Therapeutic strategies for early-stage non-small cell lung cancer (NSCLC) are advancing, with immune checkpoint inhibitors (ICIs) and targeted therapies making their way into neoadjuvant and adjuvant settings. With recent advances, there was a need f
Externí odkaz:
https://doaj.org/article/234336a74a674bd18fa75f41a4f0977a
Publikováno v:
Nonlinear Processes in Geophysics, Vol 9, Iss 2, Pp 121-124 (2002)
We consider the role that the lower-hybrid wave turbulence plays in providing the necessary resistivity at collisionless reconnection sights. The mechanism for generating the waves is considered to be the lower-hybrid drift instability. We find that
Externí odkaz:
https://doaj.org/article/04f0e49566574307bde3964e4d35acdf
Autor:
Cathleen Hagemann, Matthew C D Bailey, Eugenia Carraro, Ksenia S Stankevich, Valentina Maria Lionello, Noreen Khokhar, Pacharaporn Suklai, Carmen Moreno-Gonzalez, Kelly O'Toole, George Konstantinou, Christina L Dix, Sudeep Joshi, Eleonora Giagnorio, Mads S Bergholt, Christopher D Spicer, Albane Imbert, Francesco Saverio Tedesco, Andrea Serio
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002503 (2024)
Cell culture devices, such as microwells and microfluidic chips, are designed to increase the complexity of cell-based models while retaining control over culture conditions and have become indispensable platforms for biological systems modelling. Fr
Externí odkaz:
https://doaj.org/article/59f8f15ac4084afe9652b3996f842f8d
Autor:
Philippe Joubert, Azadeh Arabzadeh, Valérie Breton, Mark Sorin, Elham Karimi, Morteza Rezanejad, Miranda W Yu, Lysanne Desharnais, Sheri A C McDowell, Samuel Doré, Benoit Fiset, Yuhong Wei, Roni Rayes, Michele Orain, Francois Coulombe, Venkata S K Manem, Andreanne Gagne, Daniela F Quail, Jonathan D Spicer, Logan A Walsh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Immunotherapy has revolutionized clinical outcomes for patients suffering from lung cancer, yet relatively few patients sustain long-term durable responses. Recent studies have demonstrated that the tumor immune microenvironment fosters tu
Externí odkaz:
https://doaj.org/article/b3889797f7b44bc4821c45531186df0a
Autor:
Christopher D. Spicer, Michael Pujari-Palmer, Hélène Autefage, Gerard Insley, Philip Procter, Håkan Engqvist, Molly M. Stevens
Publikováno v:
ACS Central Science, Vol 6, Iss 2, Pp 226-231 (2020)
Externí odkaz:
https://doaj.org/article/8b88ae8638334a00b23f0ec6659ff24a
Autor:
Henry Y. Jiang, Sara Najmeh, Guy Martel, Elyse MacFadden-Murphy, Raquel Farias, Paul Savage, Arielle Leone, Lucie Roussel, Jonathan Cools-Lartigue, Stephen Gowing, Julie Berube, Betty Giannias, France Bourdeau, Carlos H. F. Chan, Jonathan D. Spicer, Rebecca McClure, Morag Park, Simon Rousseau, Lorenzo E. Ferri
Publikováno v:
Protein & Cell, Vol 11, Iss 3, Pp 187-201 (2020)
Abstract While emerging data suggest nucleotide oligomerization domain receptor 1 (NOD1), a cytoplasmic pattern recognition receptor, may play an important and complementary role in the immune response to bacterial infection, its role in cancer metas
Externí odkaz:
https://doaj.org/article/541092789c6343c9b39f754dcedac5c4
Autor:
Sophie M.-C. Gobeil, Benjamin G. Bobay, Praveen R. Juvvadi, D. Christopher Cole, Joseph Heitman, William J. Steinbach, Ronald A. Venters, Leonard D. Spicer
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so e
Externí odkaz:
https://doaj.org/article/0963e345cfb74f47bf957fdadaef28c6
Autor:
Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less imm
Externí odkaz:
https://doaj.org/article/4b8d65315776423982c1bea6612cead9
Autor:
Yibo Xue, Brian Meehan, Zheng Fu, Xue Qing D. Wang, Pierre Olivier Fiset, Ralf Rieker, Cameron Levins, Tim Kong, Xianbing Zhu, Geneviève Morin, Lashanda Skerritt, Esther Herpel, Sriram Venneti, Daniel Martinez, Alexander R. Judkins, Sungmi Jung, Sophie Camilleri-Broet, Anne V. Gonzalez, Marie-Christine Guiot, William W. Lockwood, Jonathan D. Spicer, Abbas Agaimy, William A. Pastor, Josée Dostie, Janusz Rak, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Non-small cell lung cancers with inactivating SMARCA4 mutations are currently undruggable. Here, the authors show that the absence of SMARCA4/2 reduces chromatin accessibility at the CCND1 locus, leading to a subsequent reduction in cyclin D1 express
Externí odkaz:
https://doaj.org/article/f919a450f672493c812a00c6c5045ab6
Autor:
Victor Brochu, MDCM, Gurdip Singh Tamber, MD, Roni F. Rayes, PhD, Benoit Fiset, BSc, Derin Caglar, MD, Sophie Camilleri-Broët, MD, PhD, Roger Tabah, MD, Logan A. Walsh, PhD, Jonathan D. Spicer, MD, PhD, Pierre Olivier Fiset, MDCM, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 2, Iss 5, Pp 100169- (2021)
Introduction: Primary carcinomas of the trachea are rare, with a reported annual incidence of one in a million. We present a case of a previously undescribed polypoid high-grade neuroendocrine carcinoma of the trachea. Resection of the carcinoma reve
Externí odkaz:
https://doaj.org/article/7c7972bc2cd04068ad54398c2dc9e80c