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Akademický článek

Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report

Autor: Marie-Anne Meier, Sandro Nuciforo, Mairene Coto-Llerena, John Gallon, Matthias S. Matter, Caner Ercan, Jürg Vosbeck, Luigi M. Terracciano, Savas D. Soysal, Daniel Boll, Otto Kollmar, Raphaël Delaloye, Salvatore Piscuoglio, Markus H. Heim

Publikováno v: Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)

Meier, Nuciforo, Coto-Llerena et al. report a rare case of a patient with hepatocellular carcinoma with neuroendocrine differentiation. The authors establish organoids that recapitulate the genetic features of the patient’s tumor and are used for e

Externí odkaz: https://doaj.org/article/092df1cdee254031870f4d0caaa0bd75

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Akademický článek

Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma

Publikováno v: Molecular Oncology, Vol 16, Iss 3, Pp 665-682 (2022)

Hepatocellular carcinomas (HCCs) usually arise from chronic liver disease (CLD). Precancerous cells in chronically inflamed environments may be ‘epigenetically primed’, sensitising them to oncogenic transformation. We investigated whether epigene

Externí odkaz: https://doaj.org/article/01ede92b5b01440d89da11c31958e65e

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Akademický článek

Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report

Publikováno v: Communications Medicine, Vol 2, Iss 1, Pp 1-8 (2022)

Plain language summary Focal nodular hyperplasia (FNH) is a lesion resulting from the abnormal growth of liver cells. It is typically considered a benign tumor that does not become malignant. In rare cases, FNH may occur alongside malignant hepatocel

Externí odkaz: https://doaj.org/article/49161dc05fb841fc951e15d1ae5a8794

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Akademický článek

Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo‐Independent Regulation of Heat Shock Protein 70 Family Members

Publikováno v: Hepatology Communications, Vol 5, Iss 4, Pp 661-674 (2021)

Transcriptional enhancer factor domain family member 4 (TEAD4) is a downstream effector of the conserved Hippo signaling pathway, regulating the expression of genes involved in cell proliferation and differentiation. It is up‐regulated in several c

Externí odkaz: https://doaj.org/article/ad421c0d13494136915e7f00b44e48ef

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Akademický článek

The Role of Chronic Liver Diseases in the Emergence and Recurrence of Hepatocellular Carcinoma: An Omics Perspective

Autor: Sofia Zanotti, Gina F. Boot, Mairene Coto-Llerena, John Gallon, Gabriel F. Hess, Savas D. Soysal, Otto Kollmar, Charlotte K. Y. Ng, Salvatore Piscuoglio

Publikováno v: Frontiers in Medicine, Vol 9 (2022)

Hepatocellular carcinoma (HCC) typically develops from a background of cirrhosis resulting from chronic inflammation. This inflammation is frequently associated with chronic liver diseases (CLD). The advent of next generation sequencing has enabled e

Externí odkaz: https://doaj.org/article/8a66c79ba6ce4402b89db4555700e707

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Akademický článek

Standardizing Patient-Derived Organoid Generation Workflow to Avoid Microbial Contamination From Colorectal Cancer Tissues

Publikováno v: Frontiers in Oncology, Vol 11 (2022)

The use of patient-derived organoids (PDO) as a valuable alternative to in vivo models significantly increased over the last years in cancer research. The ability of PDOs to genetically resemble tumor heterogeneity makes them a powerful tool for pers

Externí odkaz: https://doaj.org/article/46f54f28e2a04b6b8aeeecf5a0b65447

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Akademický článek

Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer

Autor: Robert Mechera, Savas D. Soysal, Salvatore Piscuoglio, Charlotte K. Y. Ng, Jasmin Zeindler, Edin Mujagic, Silvio Däster, Philippe Glauser, Henry Hoffmann, Ergin Kilic, Raoul A. Droeser, Walter P. Weber, Simone Muenst

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)

Abstract Background The Rearranged during Transfection (RET) protein is overexpressed in a subset of Estrogen Receptor (ER) positive breast cancer, with both signalling pathways functionally interacting. This cross-talk plays a pivotal role in the re

Externí odkaz: https://doaj.org/article/5c49c750c1db409b9ceec48f5cd590dd

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Akademický článek

High Expression of FAP in Colorectal Cancer Is Associated With Angiogenesis and Immunoregulation Processes

Autor: Mairene Coto-Llerena, Caner Ercan, Venkatesh Kancherla, Stephanie Taha-Mehlitz, Serenella Eppenberger-Castori, Savas D. Soysal, Charlotte K. Y. Ng, Martin Bolli, Markus von Flüe, Guillaume P. Nicolas, Luigi M. Terracciano, Melpomeni Fani, Salvatore Piscuoglio

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Fibroblast activation protein α (FAP) plays an important role in tissue remodeling and helps tumor cells invade surrounding tissue. We sought to investigate FAP as a prognostic molecular marker in colorectal cancer (CRC) using immunohistochemical an

Externí odkaz: https://doaj.org/article/6f5808a753d44eb9a73ade37bf98aac5

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Akademický článek

Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis

Autor: Silvio Däster, Serenella Eppenberger-Castori, Valentina Mele, Hannah M. Schäfer, Lukas Schmid, Benjamin Weixler, Savas D. Soysal, Raoul A. Droeser, Giulio C. Spagnoli, Christoph Kettelhack, Daniel Oertli, Luigi Terracciano, Luigi Tornillo, Urs von Holzen

Publikováno v: Frontiers in Medicine, Vol 7 (2020)

Prognosis of gastric and esophageal cancer is poor and treatment improvements are needed. Programmed cell death 1 receptor (PD-1) interaction with its ligand PD-L1 in tumor micro-environment promotes immune tolerance and blocking monoclonal antibodie

Externí odkaz: https://doaj.org/article/4751443826274a429cf6b643bb3a11d0

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Comparison of patient-reported outcomes among different types of oncoplastic breast surgery procedures

Autor: Mathilde Ritter, Ida Oberhauser, Giacomo Montagna, Lea Zehnpfennig, Kristin Schaefer, Barbara M. Ling, Jeremy Levy, Savas D. Soysal, Madleina Müller, Liliana Castrezana López, Fabienne D. Schwab, Christian Kurzeder, Martin Haug, Elisabeth A. Kappos, Walter P. Weber

Publikováno v: Journal of Plastic, Reconstructive & Aesthetic Surgery. 75:3068-3077

This study aims to compare patient-reported outcomes (PROs) after different types of oncoplastic surgery (OPS) procedures and correlate the results with previously published normative data from women with no prior history of breast cancer (BC) and br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589a9cabc6fefa2ac5e8a907facce94b
https://doi.org/10.1016/j.bjps.2022.04.051

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