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Akademický článek

Identification of Kinases Responsible for p53-Dependent Autophagy

Autor: Stephanie L. Celano, Lisette P. Yco, Matthew G. Kortus, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Edward Spooner, Ronan C. O'Hagan, Peter Fuller, Katie R. Martin, Stuart D. Shumway, Jeffrey P. MacKeigan

Publikováno v: iScience, Vol 15, Iss , Pp 109-118 (2019)

Summary: In cancer, autophagy is upregulated to promote cell survival and tumor growth during times of nutrient stress and can confer resistance to drug treatments. Several major signaling networks control autophagy induction, including the p53 tumor

Externí odkaz: https://doaj.org/article/1963b7c4000c4a54a648f6f246f51215

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Akademický článek

A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress

Autor: Katie R. Martin, Stephanie L. Celano, Abigail R. Solitro, Hakan Gunaydin, Mark Scott, Ronan C. O'Hagan, Stuart D. Shumway, Peter Fuller, Jeffrey P. MacKeigan

Publikováno v: iScience, Vol 8, Iss , Pp 74-84 (2018)

Summary: In response to stress, cancer cells generate nutrients and energy through a cellular recycling process called autophagy, which can promote survival and tumor progression. Accordingly, autophagy inhibition has emerged as a potential cancer tr

Externí odkaz: https://doaj.org/article/da31c51b36c548718b2b7aeb41c96998

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