Zobrazeno 1 - 10
of 953
pro vyhledávání: '"D. Shultz"'
Autor:
Martha E. Barta, Greg G. Sass, Jeffrey R. Reed, Thomas A. Cichosz, Aaron D. Shultz, Mark Luehring, Zachary S. Feiner
Publikováno v:
Limnology and Oceanography Letters, Vol 9, Iss 3, Pp 229-236 (2024)
Abstract The phenology of critical biological events in aquatic ecosystems is rapidly shifting due to climate change. Growing variability in phenological cues can increase the likelihood of trophic mismatches (i.e., mismatches in the timing of peak p
Externí odkaz:
https://doaj.org/article/e4eebac615fa40b4848f7b90c3035075
Autor:
Milita Darguzyte, Philipp Antczak, Daniel Bachurski, Patrick Hoelker, Nima Abedpour, Rahil Gholamipoorfard, Hans A. Schlößer, Kerstin Wennhold, Martin Thelen, Maria A. Garcia-Marquez, Johannes Koenig, Andreas Schneider, Tobias Braun, Frank Klawonn, Michael Damrat, Masudur Rahman, Jan-Malte Kleid, Sebastian J. Theobald, Eugen Bauer, Constantin von Kaisenberg, Steven R. Talbot, Leonard D. Shultz, Brian Soper, Renata Stripecke
Publikováno v:
Cells, Vol 13, Iss 20, p 1686 (2024)
Background: Humanized mice transplanted with CD34+ hematopoietic cells (HPCs) are broadly used to study human immune responses and infections in vivo and for testing therapies pre-clinically. However, until now, it was not clear whether interactions
Externí odkaz:
https://doaj.org/article/633b76dd515d43d3b3abd9316c52d10a
Autor:
Taylor A. Stepien, Larissa A. Singletary, Fermin E. Guerra, Joyce E. Karlinsey, Stephen J. Libby, Sarah L. Jaslow, Margaret R. Gaggioli, Kyle D. Gibbs, Dennis C. Ko, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Ferric C. Fang
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTSalmonella serovars Typhi and Paratyphi cause a prolonged illness known as enteric fever, whereas other serovars cause acute gastroenteritis. Mechanisms responsible for the divergent clinical manifestations of nontyphoidal and enteric fever S
Externí odkaz:
https://doaj.org/article/557b291ef5774526961df87681eb966d
Autor:
Sungwook Jung, Liwei Jiang, Jing Zhao, Leonard D. Shultz, Dale L. Greiner, Munhyung Bae, Xiaofei Li, Farideh Ordikhani, Rui Kuai, John Joseph, Vivek Kasinath, David R. Elmaleh, Reza Abdi
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Targeted drug delivery systems hold the remarkable potential to improve the therapeutic index of anticancer medications markedly. Here, we report a targeted delivery platform for cancer treatment using clathrin light chain (CLC)‐conjugated
Externí odkaz:
https://doaj.org/article/6d669f23ea8149e9a0f338ab025c1c27
Autor:
Peishan Li, Ming Lu, Jiayuan Shi, Li Hua, Zheng Gong, Qing Li, Leonard D. Shultz, Guangwen Ren
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The role of neutrophils in the regulation of tumour growth and metastasis remains controversial. Here, the authors demonstrate that neutrophils, by exerting inhibitory effects on cytotoxic NK cells, show a net pro-metastatic effect in immune-competen
Externí odkaz:
https://doaj.org/article/8e4a51d014ec4176905300fb5f285823
Autor:
Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace A. Stafford, Vivek Kohar, Leonard D. Shultz, Michael V. Wiles
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-25 (2020)
Abstract Background Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However, because different gene disruption strategies use different mechanisms to disrupt genes, the s
Externí odkaz:
https://doaj.org/article/4542729f114f4a1997e48e7b8d00f056
Autor:
Hans Minderman, Maulasri Bhatta, Gautam N Shenoy, Jenni L Loyall, Brian D Gray, Meghana Bapardekar, Alexis Conway, Raymond J Kelleher Jr, Beatriz M Carreno, Gerald Linette, Leonard D Shultz, Sathy V Balu-Iyer, Koon Yan Pak, Richard B Bankert
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/459c116054b34eebac5200ea18da9508
Autor:
Elvin Wagenblast, Maria Azkanaz, Sabrina A. Smith, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Joana Araújo, Leonard D. Shultz, Olga I. Gan, John E. Dick, Eric R. Lechman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Previous gene editing in haematopoietic stem cells (HSCs) has focussed on a heterogeneous CD34+ population. Here, the authors demonstrate high efficiency CRISPR/Cas9-based editing of purified long-term HSCs using non-homologous end joining and homolo
Externí odkaz:
https://doaj.org/article/0b4499f298ce4f27a378fb08edca0925
Autor:
Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M. Coussens, Daniel D. De Carvalho, David G. DeNardo, Jérôme Galon, Howard L. Kaufman, Tomas Kirchhoff, Michael T. Lotze, Jason J. Luke, Andy J. Minn, Katerina Politi, Leonard D. Shultz, Richard Simon, Vésteinn Thórsson, Joanne B. Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M. Barnes, Valentin Barsan, Praveen K. Bommareddy, Adrian Bot, Sarah E. Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S. Ho, Heather M. McGee, Anne Monette, Joseph F. Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F. Sweis, Sara Valpione, Roberta Zappasodi, Lisa H. Butterfield, Mary L. Disis, Bernard A. Fox, Alessandra Cesano, Francesco M. Marincola, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-23 (2019)
Abstract Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include th
Externí odkaz:
https://doaj.org/article/864f25d06ad04690a4ef2014434f0547
Autor:
Rintaro Ono, Takashi Watanabe, Eiryo Kawakami, Makoto Iwasaki, Mariko Tomizawa-Murasawa, Masashi Matsuda, Yuho Najima, Shinsuke Takagi, Saera Fujiki, Rumi Sato, Yoshiki Mochizuki, Hisahiro Yoshida, Kaoru Sato, Hiromasa Yabe, Shunichi Kato, Yoriko Saito, Shuichi Taniguchi, Leonard D. Shultz, Osamu Ohara, Masayuki Amagai, Haruhiko Koseki, Fumihiko Ishikawa
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 584-596 (2019)
Background: Graft-versus host disease (GVHD) is a complication of stem cell transplantation associated with significant morbidity and mortality. Non-specific immune-suppression, the mainstay of treatment, may result in immune-surveillance dysfunction
Externí odkaz:
https://doaj.org/article/280692afcb6f4d14804164565b679c85