Zobrazeno 1 - 10
of 726
pro vyhledávání: '"D. Sheldon"'
Autor:
Rachel (Rae) J. House, Molly T. Soper-Hopper, Michael P. Vincent, Abigail E. Ellis, Colt D. Capan, Zachary B. Madaj, Emily Wolfrum, Christine N. Isaguirre, Carlos D. Castello, Amy B. Johnson, Martha L. Escobar Galvis, Kelsey S. Williams, Hyoungjoo Lee, Ryan D. Sheldon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Metabolite extraction is the critical first-step in metabolomics experiments, where it is generally regarded to inactivate and remove proteins. Here, arising from efforts to improve extraction conditions for polar metabolomics, we discover a
Externí odkaz:
https://doaj.org/article/3c2a5db689674347bf92e9f80980aebe
Autor:
Zachary B Madaj, Michael S. Dahabieh, Vijayvardhan Kamalumpundi, Brejnev Muhire, J. Pettinga, Rebecca A. Siwicki, Abigail E. Ellis, Christine Isaguirre, Martha L. Escobar Galvis, Lisa DeCamp, Russell G. Jones, Scott A. Givan, Marie Adams, Ryan D. Sheldon
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 186-197 (2023)
Here, we provide an in-depth analysis of the usefulness of single-sample metabolite/RNA extraction for multi-‘omics readout. Using pulverized frozen livers of mice injected with lymphocytic choriomeningitis virus (LCMV) or vehicle (Veh), we isolate
Externí odkaz:
https://doaj.org/article/04874c3865a64c46a4a4eabd9d1a05ee
Autor:
James H. Schofield, Joseph Longo, Ryan D. Sheldon, Emma Albano, Abigail E. Ellis, Mark A. Hawk, Sean Murphy, Loan Duong, Sharif Rahmy, Xin Lu, Russell G. Jones, Zachary T. Schafer
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113984- (2024)
Summary: Targeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches. However, ICB is not an efficacious strategy in a variety of cancer types, in part due to immunosuppre
Externí odkaz:
https://doaj.org/article/4c7f2836a59b4a5691fa9a3f93e654d9
Autor:
Hyunwoo Kwon, Mingjia Li, Jesse D Sheldon, Nicholas Jones, Nicolas Gallastegui Crestani, Zihai Li, Dwight H Owen
Publikováno v:
Current Problems in Cancer: Case Reports, Vol 13, Iss , Pp 100275- (2024)
Background: Hypereosinophilia, as defined by the absolute eosinophil count ≥ 1,500 cells per microliter, can be a consequence of primary (clonal) hematologic disorders or secondary response to inflammation from allergens, parasitic infections, medi
Externí odkaz:
https://doaj.org/article/63b3ae364f6a47d482bab0d6b931a119
Autor:
Isabella C. Fahrenholz, Michelle M. Dennis, Federica Morandi, Keren E. Dittmer, Julie D. Sheldon
Publikováno v:
Animals, Vol 14, Iss 14, p 2088 (2024)
Severe musculoskeletal disease characterized by marked joint laxity was the cause of euthanasia in two wild juvenile American black bears (Ursus americanus) admitted to a rehabilitation facility in eastern Tennessee in 2023. Previously, almost all re
Externí odkaz:
https://doaj.org/article/2aaa96614af4445fbb554d39cb54c9fe
Autor:
Rachel (Rae) J. House, Elizabeth A. Tovar, Luke N. Redlon, Curt J. Essenburg, Patrick S. Dischinger, Abigail E. Ellis, Ian Beddows, Ryan D. Sheldon, Evan C. Lien, Carrie R. Graveel, Matthew R. Steensma
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101876- (2024)
Objective: NF1 is a tumor suppressor gene and its protein product, neurofibromin, is a negative regulator of the RAS pathway. NF1 is one of the top driver mutations in sporadic breast cancer such that 27 % of breast cancers exhibit damaging NF1 alter
Externí odkaz:
https://doaj.org/article/c0cfe2d8357a4b118393af5f70ecbed2
Autor:
Renee M. Mahr, Snehalata Jena, Sereen K. Nashif, Alisa B. Nelson, Adam J. Rauckhorst, Ferrol I. Rome, Ryan D. Sheldon, Curtis C. Hughey, Patrycja Puchalska, Micah D. Gearhart, Eric B. Taylor, Peter A. Crawford, Sarah A. Wernimont
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Cytotrophoblasts fuse to form and renew syncytiotrophoblasts necessary to maintain placental health throughout gestation. During cytotrophoblast to syncytiotrophoblast differentiation, cells undergo regulated metabolic and transcriptional re
Externí odkaz:
https://doaj.org/article/4fec55be4690428399d950a1b56a17ae
Autor:
Hannah Guak, Ryan D. Sheldon, Ian Beddows, Alexandra Vander Ark, Matthew J. Weiland, Hui Shen, Russell G. Jones, Julie St-Pierre, Eric H. Ma, Connie M. Krawczyk
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Metabolic programming of the innate immune cells known as dendritic cells (DCs) changes in response to different stimuli, influencing their function. While the mechanisms behind increased glycolytic metabolism in response to inflammatory sti
Externí odkaz:
https://doaj.org/article/6f4583858e0a41b89b2cf4aaa9094f6e
Publikováno v:
Life, Vol 14, Iss 1, p 78 (2024)
Leaf stomata facilitate the exchange of water and CO2 during photosynthetic gas exchange. The shape, size, and density of leaf pores have not been constant over geologic time, and each morphological trait has potentially been impacted by changing env
Externí odkaz:
https://doaj.org/article/86c27425ba2c4c75a6b5bd623d08fefc
Autor:
Chad R. Schultz, Ryan D. Sheldon, Huirong Xie, Elena Y. Demireva, Katie L. Uhl, Dalen W. Agnew, Dirk Geerts, André S. Bachmann
Publikováno v:
Biology Open, Vol 12, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/ff03a24cbd904c6da12eb4d5b15a39df