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Akademický článek

Pain in multiple sclerosis: A systematic review of neuroimaging studies

Autor: D. Seixas, P. Foley, J. Palace, D. Lima, I. Ramos, I. Tracey

Publikováno v: NeuroImage: Clinical, Vol 5, Iss C, Pp 322-331 (2014)

Introduction: While pain in multiple sclerosis (MS) is common, in many cases the precise mechanisms are unclear. Neuroimaging studies could have a valuable role in investigating the aetiology of pain syndromes. The aim of this review was to synthesis

Externí odkaz: https://doaj.org/article/9541e7eaf3d948309d843d9416b4cc4a

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Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression

Publikováno v: Cell Mol Bioeng

INTRODUCTION: Inflammatory activation of the vascular endothelium leads to overexpression of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), contributing to the pro-thrombotic state underpinning atherogenesis. While the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::629673dc47069dbf841dd7a194fa529e
https://pubmed.ncbi.nlm.nih.gov/35611166

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Akademický článek

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A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening

Autor: Bárbara B, Sousa, Marcos F Q, Sousa, Marta C, Marques, João D, Seixas, José A, Brito, Pedro M, Matias, Gonçalo J L, Bernardes, António, Roldão

Publikováno v: Bioprocess and biosystems engineering. 44(1)

Bone Marrow Tyrosine kinase in the chromosome X (BMX) is a TEC family kinase associated with numerous pathological pathways in cancer cells. Covalent inhibition of BMX activity holds promise as a therapeutic approach against cancer. To screen for pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fd48723e2add770f3f59a9c467f713c
https://pubmed.ncbi.nlm.nih.gov/32816073

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Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors

Autor: Ana Lemos, Marta C. Marques, Shelby K. Doyle, Angela N. Koehler, Di Wu, Rui Traquete, Bárbara B. Sousa, Inês S. Albuquerque, Gonçalo J. L. Bernardes, João D Seixas, Ana Guerreiro, Francisco Corzana, Carol V. Robinson, Tiago M. Bandeiras, Tiago Rodrigues, Marcos F. Q. Sousa, Pedro M. F. Sousa, Pedro M. Matias

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
RSC Chemical Biology
'RSC Chemical Biology ', vol: 1, pages: 251-262 (2020)

This journal is © The Royal Society of Chemistry 2020.
The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0112212e065374ecc5739886d4f4e98a

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FRI0441 INFECTIOUS DISEASES RISK ASSESSMENT PRIOR TO IMMUNOMODULATION THERAPY - EXPERIENCE FROM AN INFECTIOUS DISEASES UNIT

Autor: D. Póvoas, S. Betková, H. Pinheiro, A. R. Garrote, P. Simões, F. Ramírez, E. Leal, F. Maltez, M. J. Manata, A. R. Estriga, D. Seixas

Publikováno v: Annals of the Rheumatic Diseases. 79:818.2-818

Background:The increasing use of immunomodulatory therapies has motivated the development of strategies to assess and prevent infectious diseases in these immunosuppressed patients, in whom the risk of serious infections is higher.Objectives:The aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6e781673fea34c4513765b172ae3818
https://doi.org/10.1136/annrheumdis-2020-eular.6155

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Relationship between severe hypoglycaemia, impaired awareness of hypoglycaemia, psychological distress, quality of life and cognition in type 1 diabetes

Autor: Eduardo Sepúlveda, D. Carvalho, D. Seixas, S. A. Amiel, Selene Vicente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1406::46af1dfaee34eacd637d07ff65cdfbc5
https://hdl.handle.net/10216/119379

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Technical feasibility of reusing coal combustion by-products from a thermoelectric power plant in the manufacture of fired clay bricks

Autor: D. Seixas, B. Sena da Fonseca, C. Galhano

Publikováno v: Applied Clay Science. 104:189-195

This paper intends to study the suitability of reuse a waste produced by thermoelectric power plants in the clay bricks industry. One of the main by-products is bottom ash and currently only half of these residues are reused; therefore a new environm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a40915b941a48a1044d6e60d13737047
https://doi.org/10.1016/j.clay.2014.11.030

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