Fire in lichen-rich subarctic tundra changes carbon and nitrogen cycling between ecosystem compartments but has minor effects on stocks

Autor: R. J. Heim, A. Yurtaev, A. Bucharova, W. Heim, V. Kutskir, K.-H. Knorr, C. Lampei, A. Pechkin, D. Schilling, F. Sulkarnaev, N. Hölzel

Publikováno v: Biogeosciences, Vol 19, Pp 2729-2740 (2022)

Fires are predicted to increase in Arctic regions due to ongoing climate change. Tundra fires can alter carbon and nutrient cycling and release a substantial quantity of greenhouse gases with global consequences. Yet, the long-term effects of tundra

Externí odkaz: https://doaj.org/article/db352fdd514c4227908078354cf45c60

Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases

Autor: Alistair T. Pagnamenta, Carme Camps, Edoardo Giacopuzzi, John M. Taylor, Mona Hashim, Eduardo Calpena, Pamela J. Kaisaki, Akiko Hashimoto, Jing Yu, Edward Sanders, Ron Schwessinger, Jim R. Hughes, Gerton Lunter, Helene Dreau, Matteo Ferla, Lukas Lange, Yesim Kesim, Vassilis Ragoussis, Dimitrios V. Vavoulis, Holger Allroggen, Olaf Ansorge, Christian Babbs, Siddharth Banka, Benito Baños-Piñero, David Beeson, Tal Ben-Ami, David L. Bennett, Celeste Bento, Edward Blair, Charlotte Brasch-Andersen, Katherine R. Bull, Holger Cario, Deirdre Cilliers, Valerio Conti, E. Graham Davies, Fatima Dhalla, Beatriz Diez Dacal, Yin Dong, James E. Dunford, Renzo Guerrini, Adrian L. Harris, Jane Hartley, Georg Hollander, Kassim Javaid, Maureen Kane, Deirdre Kelly, Dominic Kelly, Samantha J. L. Knight, Alexandra Y. Kreins, Erika M. Kvikstad, Craig B. Langman, Tracy Lester, Kate E. Lines, Simon R. Lord, Xin Lu, Sahar Mansour, Adnan Manzur, Reza Maroofian, Brian Marsden, Joanne Mason, Simon J. McGowan, Davide Mei, Hana Mlcochova, Yoshiko Murakami, Andrea H. Németh, Steven Okoli, Elizabeth Ormondroyd, Lilian Bomme Ousager, Jacqueline Palace, Smita Y. Patel, Melissa M. Pentony, Chris Pugh, Aboulfazl Rad, Archana Ramesh, Simone G. Riva, Irene Roberts, Noémi Roy, Outi Salminen, Kyleen D. Schilling, Caroline Scott, Arjune Sen, Conrad Smith, Mark Stevenson, Rajesh V. Thakker, Stephen R. F. Twigg, Holm H. Uhlig, Richard van Wijk, Barbara Vona, Steven Wall, Jing Wang, Hugh Watkins, Jaroslav Zak, Anna H. Schuh, Usha Kini, Andrew O. M. Wilkie, Niko Popitsch, Jenny C. Taylor

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-25 (2023)

Abstract Background Whole genome sequencing is increasingly being used for the diagnosis of patients with rare diseases. However, the diagnostic yields of many studies, particularly those conducted in a healthcare setting, are often disappointingly l

Externí odkaz: https://doaj.org/article/c9f00f4d0c70402d8c69f3f7e4981fbc

Adipose-targeted SWELL1 deletion exacerbates obesity- and age-related nonalcoholic fatty liver disease

Autor: Susheel K. Gunasekar, John Heebink, Danielle H. Carpenter, Ashutosh Kumar, Litao Xie, Haixia Zhang, Joel D. Schilling, Rajan Sah

Publikováno v: JCI Insight, Vol 8, Iss 5 (2023)

Healthy expansion of adipose tissue is critical for the maintenance of metabolic health, providing an optimized reservoir for energy storage in the form of triacylglycerol-rich lipoproteins. Dysfunctional adipocytes that are unable to efficiently sto

Externí odkaz: https://doaj.org/article/14ee9bf53bc94ff0b590de2094e4a81a

VKORC1 and Novel CYP2C9 Variation Predict Warfarin Response in Alaska Native and American Indian People

Autor: Lindsay M. Henderson, Renee F. Robinson, Lily Ray, Burhan A. Khan, Tianran Li, Denise A. Dillard, Brian D. Schilling, Mike Mosley, Patricia L. Janssen, Alison E. Fohner, Allan E. Rettie, Kenneth E. Thummel, Timothy A. Thornton, David L. Veenstra

Publikováno v: Clinical and Translational Science, Vol 12, Iss 3, Pp 312-320 (2019)

Alaska Native and American Indian (AN/AI) people have unique pharmacogene variation that may affect warfarin disposition and therapeutic response. We performed targeted genotyping for cytochrome P450 (CYP)2C9, vitamin K epoxide oxidase reductase comp

Externí odkaz: https://doaj.org/article/24dfd5d4d6b04ffdb379e9c74e4862ad

Impact of New UNOS Allocation Criteria on Heart Transplant Practices and Outcomes

Autor: Jason Liu, MD,, Bin Q. Yang, MD,, Akinobu Itoh, MD, PhD,, Mohammed Faraz Masood, MD,, Justin C. Hartupee, MD, PhD,, Joel D. Schilling, MD, PhD

Publikováno v: Transplantation Direct, Vol 7, Iss 1, p e642 (2021)

Background. In October 2018, a new heart allocation policy was implemented with intent of prioritizing the sickest patients and decreasing waitlist time. We examined the effects of the new policy on transplant practices and outcomes 1 year before and

Externí odkaz: https://doaj.org/article/7e9fe018669b4968b985dcc05f031bbb