Zobrazeno 1 - 10
of 684
pro vyhledávání: '"D. Scharer"'
Autor:
Weirong Chen, So-Hee Hong, Scott A. Jenks, Fabliha A. Anam, Christopher M. Tipton, Matthew C. Woodruff, Jennifer R. Hom, Kevin S. Cashman, Caterina Elisa Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D. Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C. Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, F. Eun-Hyung Lee, Ignacio Sanz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells (LLPC). Active SLE generates increased circulating antibody-secreting cells (ASC)
Externí odkaz:
https://doaj.org/article/32d01e342442483b94987433b744c8c5
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The germinal center response or reaction (GCR) is a hallmark event of adaptive humoral immunity. Unfolding in the B cell follicles of the secondary lymphoid organs, a GC culminates in the production of high-affinity antibody-secreting plasma cells al
Externí odkaz:
https://doaj.org/article/5e589c15bc734046aa4a472526fd8801
Autor:
James R. Rose, Bagdeser Akdogan-Ozdilek, Andrew R. Rahmberg, Michael D. Powell, Sakeenah L. Hicks, Christopher D. Scharer, Jeremy M. Boss
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
An integrated analysis uncovers transcriptional and epigenetic differences of human circulating memory T cell subsets and identifies unique transcription factor networks associated with memory subset differentiation.
Externí odkaz:
https://doaj.org/article/a067bd43035a480cbc06a1f70910044e
Autor:
Miranda L. Curtiss, Alexander F. Rosenberg, Christopher D. Scharer, Betty Mousseau, Natalia A. Ballesteros Benavides, John E. Bradley, Beatriz León, Chad Steele, Troy D. Randall, Frances E. Lund
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionData from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease.MethodsTo address whether Chi3l1 also contributes to TH2 response
Externí odkaz:
https://doaj.org/article/cac7025d889a467685c55cbc25d7bc30
Autor:
Zhihong Zuo, Anna K. Kania, Dillon G. Patterson, Sakeenah L. Hicks, Jeffrey Maurer, Mansi Gupta, Jeremy M. Boss, Christopher D. Scharer
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17527- (2023)
The transcription factor Interferon regulatory factor 8 (IRF8) is involved in maintaining B cell identity. However, how IRF8 regulates T cell independent B cell responses are not fully characterized. Here, an in vivo CRISPR/Cas9 system was optimized
Externí odkaz:
https://doaj.org/article/e2d535e0932a4c759017e58be7c52fae
Autor:
Miyoung Lee, Jamie A. G. Hamilton, Ganesh R. Talekar, Anthony J. Ross, Langston Michael, Manali Rupji, Bhakti Dwivedi, Sunil S. Raikar, Jeremy Boss, Christopher D. Scharer, Douglas K. Graham, Deborah DeRyckere, Christopher C. Porter, Curtis J. Henry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Obesity has been reported to promote tumourigenesis and chemoresistance but the underlying mechanisms are not completely understood. Here, the authors show that adipocytes induce Galectin-9 (GAL-9) expression in B-acute lymphoblastic leukaemia (B-ALL
Externí odkaz:
https://doaj.org/article/2dbae7c4d3ee43d79487bfe5ab1bc1e6
Autor:
Miyoung Lee, Delaney K. Geitgey, Jamie A. G. Hamilton, Jeremy M. Boss, Christopher D. Scharer, Jennifer M. Spangle, Karmella A. Haynes, Curtis J. Henry
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The world’s population with obesity is reaching pandemic levels. If current trends continue, it is predicted that there will be 1.5 billion people with obesity by 2030. This projection is alarming due to the association of obesity with numerous dis
Externí odkaz:
https://doaj.org/article/256b4796d3674787b290beebc2961457
Autor:
Christopher D. Scharer, Dillon G. Patterson, Tian Mi, Madeline J. Price, Sakeenah L. Hicks, Jeremy M. Boss
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The development of activated B cells into antibody-secreting cells (ASC) is a critical step for humoral immunity. Here the authors show, using adoptive transfers and single cell RNA sequencing, that commitment to ASC occurs soon following B cell acti
Externí odkaz:
https://doaj.org/article/279286b32b4a46bfa72d332ce28e2321
Autor:
Martin A. Rivas, Ceyda Durmaz, Andreas Kloetgen, Cristopher R. Chin, Zhengming Chen, Bhavneet Bhinder, Amnon Koren, Aaron D. Viny, Christopher D. Scharer, Jeremy M. Boss, Olivier Elemento, Christopher E. Mason, Ari M. Melnick
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The cohesin complex plays critical roles in genomic stability and gene expression through effects on 3D architecture. Cohesin core subunit genes are mutated across a wide cross-section of cancers, but not in germinal center (GC) derived lymphomas. In
Externí odkaz:
https://doaj.org/article/d81425a378284c1c898ba5565c38ac34
Autor:
Delaney K Geitgey, Miyoung Lee, Kirsten A Cottrill, Maya Jaffe, William Pilcher, Swati Bhasin, Jessica Randall, Anthony J Ross, Michelle Salemi, Marisol Castillo-Castrejon, Matthew B Kilgore, Ayjha C Brown, Jeremy M Boss, Rich Johnston, Anne M Fitzpatrick, Melissa L Kemp, Robert English, Eric Weaver, Pritha Bagchi, Ryan Walsh, Christopher D Scharer, Manoj Bhasin, Joshua D Chandler, Karmella A Haynes, Elizabeth A Wellberg, Curtis J Henry
Publikováno v:
JNCI Monographs. 2023:12-29
The obesity pandemic currently affects more than 70 million Americans and more than 650 million individuals worldwide. In addition to increasing susceptibility to pathogenic infections (eg, SARS-CoV-2), obesity promotes the development of many cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9396a87f835a7bb1a7e43be83238dc4e
https://doi.org/10.1093/jncimonographs/lgad014
https://doi.org/10.1093/jncimonographs/lgad014