Zobrazeno 1 - 10
of 734
pro vyhledávání: '"D. SHERIDAN"'
Autor:
Seda Yasa, Elisabeth S. Butz, Alessio Colombo, Uma Chandrachud, Luca Montore, Sarah Tschirner, Matthias Prestel, Steven D. Sheridan, Stephan A. Müller, Janos Groh, Stefan F. Lichtenthaler, Sabina Tahirovic, Susan L. Cotman
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Loss-of-function mutations in CLN3 cause juvenile Batten disease, featuring neurodegeneration and early-stage neuroinflammation. How loss of CLN3 function leads to early neuroinflammation is not yet understood. Here, we have comprehensively
Externí odkaz:
https://doaj.org/article/0249f9c9d7da49e085adce9537d2335d
Autor:
Lydia L. Shook, Rebecca E. Batorsky, Rose M. De Guzman, Liam T. McCrea, Sara M. Brigida, Joy E. Horng, Steven D. Sheridan, Olha Kholod, Aidan M. Cook, Jonathan Z. Li, Donna K. Slonim, Brittany A. Goods, Roy H. Perlis, Andrea G. Edlow
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background The SARS-CoV-2 virus activates maternal and placental immune responses. Such activation in the setting of other infections during pregnancy is known to impact fetal brain development. The effects of maternal immune activation on n
Externí odkaz:
https://doaj.org/article/36803db3dda24d3984f9b94b2c6037ad
Autor:
Francesca Rapino, Ted Natoli, Francesco Limone, Erin O’Connor, Jack Blank, Matthew Tegtmeyer, William Chen, Erika Norabuena, Juhi Narula, Dane Hazelbaker, Gabriella Angelini, Lindy Barrett, Alison O’Neil, Ursula K. Beattie, Jessica M. Thanos, Heather de Rivera, Steven D. Sheridan, Roy H. Perlis, Steven A. McCarroll, Beth Stevens, Aravind Subramanian, Ralda Nehme, Lee L. Rubin
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 237-253 (2023)
Summary: In the brain, the complement system plays a crucial role in the immune response and in synaptic elimination during normal development and disease. Here, we sought to identify pathways that modulate the production of complement component 4 (C
Externí odkaz:
https://doaj.org/article/660be2f0da164413bfeab8d8ecac144d
Autor:
Jessica Gracias, Funda Orhan, Elin Hörbeck, Jessica Holmén-Larsson, Neda Khanlarkani, Susmita Malwade, Sravan K. Goparaju, Lilly Schwieler, İlknur Ş. Demirel, Ting Fu, Helena Fatourus-Bergman, Aurimantas Pelanis, Carleton P. Goold, Anneli Goulding, Kristina Annerbrink, Anniella Isgren, Timea Sparding, Martin Schalling, Viviana A. Carcamo Yañez, Jens C. Göpfert, Johanna Nilsson, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, Göran Engberg, Fredrik Piehl, Steven D. Sheridan, Roy H. Perlis, Simon Cervenka, Sophie Erhardt, Mikael Landen, Carl M. Sellgren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Schizophrenia risk has been associated with the complement component 4 (C4) genes. Here the authors show that C4A is elevated in individuals with schizophrenia.
Externí odkaz:
https://doaj.org/article/150d41d1b51449f59ed17607f34db912
Autor:
Thomas Parmentier, Fiona M. K. James, Elizabeth Hewitson, Craig Bailey, Nicholas Werry, Steven D. Sheridan, Roy H. Perlis, Melissa L. Perreault, Luis Gaitero, Jasmin Lalonde, Jonathan LaMarre
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Activity-induced neurogenesis has been extensively studied in rodents but the lack of ante mortem accessibility to human brain at the cellular and molecular levels limits studies of the process in humans. Using cerebral spheroids derived fro
Externí odkaz:
https://doaj.org/article/9147bd989f8143aaa15097455ee1c091
Autor:
Steven D. Sheridan, Jessica M. Thanos, Rose M. De Guzman, Liam T. McCrea, Joy E. Horng, Ting Fu, Carl M. Sellgren, Roy H. Perlis, Andrea G. Edlow
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a
Externí odkaz:
https://doaj.org/article/1200a4df08474dbdab686afff0fab8e8
Autor:
Wen-Ning Zhao, Brian T. D. Tobe, Namrata D. Udeshi, Lucius L. Xuan, Cameron D. Pernia, Daniel P. Zolg, Amanda J. Roberts, Deepak Mani, Sarah R. Blumenthal, Iren Kurtser, Debasis Patnaik, Irina Gaisina, Joshua Bishop, Steven D. Sheridan, Jasmin Lalonde, Steven A. Carr, Evan Y. Snyder, Stephen J. Haggarty
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract The effective treatment of bipolar disorder (BD) represents a significant unmet medical need. Although lithium remains a mainstay of treatment for BD, limited knowledge regarding how it modulates affective behavior has proven an obstacle to
Externí odkaz:
https://doaj.org/article/3adcd41d1c9642cb98771f72e34b370f
Autor:
Pauline Martin, Vilas Wagh, Surya A. Reis, Serkan Erdin, Roberta L. Beauchamp, Ghalib Shaikh, Michael Talkowski, Elizabeth Thiele, Steven D. Sheridan, Stephen J. Haggarty, Vijaya Ramesh
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-15 (2020)
Abstract Background Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder with frequent occurrence of epilepsy, autism spectrum disorder (ASD), intellectual disability (ID), and tumors in multiple organs. The aberrant activation of mTORC1
Externí odkaz:
https://doaj.org/article/dacfeeaa9c15418ea8850ec47e4871cc
Autor:
Cassandra Duarte, MD, Danielle M. Gilbert, BA, Alison D. Sheridan, MD, Francisco G. La Rosa, MD, Martin McCarter, MD, Nicholas G. Cost, MD, Steven Emmons, MD, Elaine T. Lam, MD, FACP
Publikováno v:
Cancer Treatment and Research Communications, Vol 28, Iss , Pp 100383- (2021)
Externí odkaz:
https://doaj.org/article/999fd612e4e7480098183efa7f8752f2
Autor:
Hun-Goo Lee, Sachiko Imaichi, Elizabeth Kraeutler, Rodrigo Aguilar, Yong-Woo Lee, Steven D. Sheridan, Jeannie T. Lee
Publikováno v:
Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d92255cbd96fddfe9271786e74796d0
https://doi.org/10.1016/j.cell.2023.04.035
https://doi.org/10.1016/j.cell.2023.04.035