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Akademický článek

Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover

Autor: Seda Yasa, Elisabeth S. Butz, Alessio Colombo, Uma Chandrachud, Luca Montore, Sarah Tschirner, Matthias Prestel, Steven D. Sheridan, Stephan A. Müller, Janos Groh, Stefan F. Lichtenthaler, Sabina Tahirovic, Susan L. Cotman

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)

Abstract Loss-of-function mutations in CLN3 cause juvenile Batten disease, featuring neurodegeneration and early-stage neuroinflammation. How loss of CLN3 function leads to early neuroinflammation is not yet understood. Here, we have comprehensively

Externí odkaz: https://doaj.org/article/0249f9c9d7da49e085adce9537d2335d

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Akademický článek

Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment

Autor: Lydia L. Shook, Rebecca E. Batorsky, Rose M. De Guzman, Liam T. McCrea, Sara M. Brigida, Joy E. Horng, Steven D. Sheridan, Olha Kholod, Aidan M. Cook, Jonathan Z. Li, Donna K. Slonim, Brittany A. Goods, Roy H. Perlis, Andrea G. Edlow

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)

Abstract Background The SARS-CoV-2 virus activates maternal and placental immune responses. Such activation in the setting of other infections during pregnancy is known to impact fetal brain development. The effects of maternal immune activation on n

Externí odkaz: https://doaj.org/article/36803db3dda24d3984f9b94b2c6037ad

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Akademický článek

Mary D Sheridan, O.B.E., M.A., M.D., F.F.C.M., D.C.H.

Publikováno v: The British Medical Journal, 1978 Apr . 1(6119), 1059-1060.

Externí odkaz: https://www.jstor.org/stable/20418759

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Akademický článek

Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

Publikováno v: Stem Cell Reports, Vol 18, Iss 1, Pp 237-253 (2023)

Summary: In the brain, the complement system plays a crucial role in the immune response and in synaptic elimination during normal development and disease. Here, we sought to identify pathways that modulate the production of complement component 4 (C

Externí odkaz: https://doaj.org/article/660be2f0da164413bfeab8d8ecac144d

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Akademický článek

Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Schizophrenia risk has been associated with the complement component 4 (C4) genes. Here the authors show that C4A is elevated in individuals with schizophrenia.

Externí odkaz: https://doaj.org/article/150d41d1b51449f59ed17607f34db912

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Akademický článek

Human cerebral spheroids undergo 4-aminopyridine-induced, activity associated changes in cellular composition and microrna expression

Autor: Thomas Parmentier, Fiona M. K. James, Elizabeth Hewitson, Craig Bailey, Nicholas Werry, Steven D. Sheridan, Roy H. Perlis, Melissa L. Perreault, Luis Gaitero, Jasmin Lalonde, Jonathan LaMarre

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Activity-induced neurogenesis has been extensively studied in rodents but the lack of ante mortem accessibility to human brain at the cellular and molecular levels limits studies of the process in humans. Using cerebral spheroids derived fro

Externí odkaz: https://doaj.org/article/9147bd989f8143aaa15097455ee1c091

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