Zobrazeno 1 - 10
of 49
pro vyhledávání: '"D. S. Sitar"'
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 72:161-167
Kynurenic acid (KYN), an antagonist of excitatory amino acid receptors, is a putative antidote against neuroexcitatory amino acid toxicity. We studied various doses (0.05–3.17 mmol/kg, i.p.) and the effects of probenecid coadministration (0.70 mmol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed298982902335c7f52321eba847f4b1
https://doi.org/10.1139/y94-025
https://doi.org/10.1139/y94-025
Publikováno v:
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique. 8(4)
The bioavailabilities of acyclovir from capsules of valacyclovir, the L-valyl ester of acyclovir, and acyclovir were compared by measuring urinary excretion of the drug in a double blind, placebo-controlled field trial of patient-initiated treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d74d1581406d02a065f22215a4fc9320
https://pubmed.ncbi.nlm.nih.gov/11743593
https://pubmed.ncbi.nlm.nih.gov/11743593
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
Amantadine acetylation was demonstrated to occur both in vivo and in vitro using transgenic male mice overexpressing spermidine/spermine N(1)-acetyltransferase (SSAT). We previously reported that neither NAT1 nor NAT2 was responsible for catalyzing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b78d36a1ebec943c6c74d4838c18bd02
https://pubmed.ncbi.nlm.nih.gov/11302933
https://pubmed.ncbi.nlm.nih.gov/11302933
Publikováno v:
Canadian journal of physiology and pharmacology. 79(1)
The effects of early-stage diabetes mellitus and uninephrectomy on the renal tubule transport of amantadine were investigated. Kidney tubules were isolated from streptozotocin-induced diabetic (+/- insulin treatment) uninephrectomized, and control ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df12ce0d8ac068f82ae8d6fa6d195180
https://pubmed.ncbi.nlm.nih.gov/11201497
https://pubmed.ncbi.nlm.nih.gov/11201497
Publikováno v:
Annals of emergency medicine. 35(5)
This study was conducted to determine whether gastric lavage reduces the absorption of ingested liquids.The study design was a randomized controlled human volunteer crossover study in 10 subjects. On 2 separate occasions 2 weeks apart, the volunteers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a74ec12c2b35b2abe54213039409a24f
https://pubmed.ncbi.nlm.nih.gov/10783405
https://pubmed.ncbi.nlm.nih.gov/10783405
Autor:
A L, Kozyrskyj, G E, Hildes-Ripstein, S E, Longstaffe, J L, Wincott, D S, Sitar, T P, Klassen, M E, Moffatt
BACKGROUND: Acute otitis media (AOM) is a common illness during childhood, for which antibiotics are frequently prescribed. OBJECTIVES: To determine the effectiveness of a short course of antibiotics (less than seven days) in comparison to a long cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7bf8db5f3ed7afc314136a7e5a3333
https://doi.org/10.1002/14651858.cd001095
https://doi.org/10.1002/14651858.cd001095
Publikováno v:
Neurochemical research. 24(12)
Experimental studies have indicated that the mechanisms offered for explaining the neurotoxicity of amyloid beta peptide (AbetaP) are diverse, and include altered enzyme activities, disrupted calcium homeostasis, and increased free radical formation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aaea0672951f740596b6a87f5d7590b
https://pubmed.ncbi.nlm.nih.gov/10591414
https://pubmed.ncbi.nlm.nih.gov/10591414
Publikováno v:
Canadian journal of physiology and pharmacology. 77(6)
Eight representative beta-adrenoreceptor blocking drugs, acebutolol, atenolol, labetalol, metoprolol, nadolol, pindolol, propranolol, and timolol, were studied in vitro with respect to their potential to block energy-dependent uptake of [3H]amantadin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c4532f8a21df27f93f794cf9c307986
https://pubmed.ncbi.nlm.nih.gov/10537226
https://pubmed.ncbi.nlm.nih.gov/10537226
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(2)
Amantadine transport into renal proximal and distal tubules is bicarbonate dependent. In the present study, we addressed the effects of bicarbonate on renal clearance and urinary excretion of amantadine. Renal clearance of kynurenic acid was also stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6b3191dc84b3d721603c3d2e73dbd69
https://pubmed.ncbi.nlm.nih.gov/10411555
https://pubmed.ncbi.nlm.nih.gov/10411555
Autor:
K B, Goralski, D S, Sitar
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(1)
Tetraethylammonium (TEA) and amantadine are two organic cations that are secreted by the kidney. It appears that each cation may characterize distinct renal tubule organic cation transport pathways. To test this hypothesis, we investigated the renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2a5ec5bbb384ceb371b349b83e4a138
https://pubmed.ncbi.nlm.nih.gov/10381790
https://pubmed.ncbi.nlm.nih.gov/10381790