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Chromosomal alterations affecting the 1cen-1q12 region in buccal mucosal cells of betel quid chewers detected using multicolor fluorescence in situ hybridization

Autor: D S Rupa, D A Eastmond

Publikováno v: Carcinogenesis. 18(12)

Epidemiological studies have shown that a high incidence of oral cancers is associated with chewing betel quid. Since chromosomal aberrations are involved in many types of cancers, we investigated whether increased frequencies of chromosomal alterati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff2fe3f4928ff93533d66df6e667121
https://pubmed.ncbi.nlm.nih.gov/9450480

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Detection of hyperdiploidy and breakage affecting the 1cen-1q12 region of cultured interphase human lymphocytes treated with various genotoxic agents

Autor: D S, Rupa, M, Schuler, D A, Eastmond

Publikováno v: Environmental and molecular mutagenesis. 29(2)

Chromosomal aberrations are associated with cancer, birth defects, and pregnancy loss. Previous studies using banding techniques have revealed that chromosomal alterations induced in human peripheral lymphocytes by many genotoxic agents occur nonrand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::430ae3b05396cab208a10c98ad166654
https://pubmed.ncbi.nlm.nih.gov/9118968

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Detection of chromosomal breakage in the 1cen-1q12 region of interphase human lymphocytes using multicolor fluorescence in situ hybridization with tandem DNA probes

Autor: D S, Rupa, L, Hasegawa, D A, Eastmond

Publikováno v: Cancer research. 55(3)

A novel multicolor fluorescence in situ hybridization approach, using an alpha satellite probe which labels the centromeric region on chromosome 1 and a classical satellite probe which targets an adjacent breakage-prone region (1q12), has been used t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4e3e8f3f62ede33f8812f7857d2ef8d
https://pubmed.ncbi.nlm.nih.gov/7834635

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Chromosomal loss and breakage in mouse bone marrow and spleen cells exposed to benzene in vivo

Autor: H, Chen, D S, Rupa, R, Tomar, D A, Eastmond

Publikováno v: Cancer research. 54(13)

Benzene is a widely recognized human and animal carcinogen. In spite of considerable research, relatively little is known about the genotoxic events that accompany benzene exposure in vivo. To gain insights into the mechanisms underlying the genotoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a7895d6deb1ff57a5fdbc15a7febf3a
https://pubmed.ncbi.nlm.nih.gov/8012977

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Multicolor Fluorescence In Situ Hybridization with Centromeric DNA Probes as a New Approach to Distinguish Chromosome Breakage from Aneuploidy in Interphase Cells and Micronuclei

Autor: D. A. Eastmond, L. Hasegawa, D. S. Rupa, H. W. Chen

Publikováno v: Chromosome Segregation and Aneuploidy ISBN: 9783642849404

Chromosomal abnormalities are believed to contribute significantly to human reproductive failure, carcinogenesis and other pathophysiological conditions (Hecht and Hecht, 1987; De Braekeleer and Dao, 1991). For example, approximately 15% of recognize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbca7c7f2e46a96b33ba91f27563d5c9
https://doi.org/10.1007/978-3-642-84938-1_30

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