Zobrazeno 1 - 10 of 96 pro vyhledávání: '"D. S. Kemp"'
3
2-Amino-2′-carboxydiphenylacetylenes as β-turn mimetics. synthesis and conformational properties
Autor: Z.Q. Li, D. S. Kemp
Publikováno v: Tetrahedron Letters. 36:4175-4178
Peptide-linked 2-amino-2′ -carboxydiphenylacetylenes 1 by 1 H NMR spectroscopy are shown to assume short sheet structures with distinctive CD signatures.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::925a1529cc4be81b44068b8226b8e489
https://doi.org/10.1016/0040-4039(95)00775-8
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4
Progress toward a novel C-terminal helix capping principle: Synthesis and properties of (S)-α-(2-aminoethyl)-methionine
Autor: Eloise C. Young, D. S. Kemp
Publikováno v: Tetrahedron Letters. 35:8315-8318
(S)-α-(2-aminoethyl)-methionine 9 ((s)-2,4-diamino-2-(3-thiabutyl)-butanoic acid) is synthesized in three steps from 1-benzoyl-2-tert--butyl-5-(3-thiabutryl)-oxazolidin-4-one. Neighboring group reactions of peptide derivatives of 9 are described.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37d2a0b9c6c875cd69412dcc5ef58e60
https://doi.org/10.1016/s0040-4039(00)74395-4
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5
Synthesis of a 39-peptide and a 25-peptide by thiol capture ligations: observation of a 40-fold rate acceleration of the intramolecular O,N-acyl-transfer reaction between peptide fragments bearing only cysteine protective groups
Autor: D. S. Kemp, Robert I. Carey
Publikováno v: The Journal of Organic Chemistry. 58:2216-2222
In this paper we report the syntheses of the 39-peptide C(Acm)LNELDADEQADL-CESLHDHADE-LYRSCLARFGDDGENL, 1, and of the 25-peptide C(Acm)LNELDADEQADL-CLARFGDDGENL, 2, by means of thiol capture ligations using precursor peptides bearing blocking groups
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12366ef4ec3dbaa76d863b0272980185
https://doi.org/10.1021/jo00060a043
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8
New templates for prior thiol capture from xanthene, dibenzo[c,h]xanthen-7-one and 2-methylenedihydrobenzofuran
Autor: David R. Buckler, D. S. Kemp
Publikováno v: Tetrahedron Letters. 32:3009-3012
The efficiencies of O,N-acyl transfer are reported for mixed disulfides from title compounds and L-Cys. EM values in the range of 1-6 M are observed for intramolecular acyl transfer with L-Cys disulfides from 7-acyloxy-2-thiomethylbenzofurans.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0018b7759c0a02caa4a45f25d1cdbcd2
https://doi.org/10.1016/0040-4039(91)80673-t
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9
Highly enantioselective amide ligation by prior thiol capture
Autor: D. S. Kemp, David R. Buckler
Publikováno v: Tetrahedron Letters. 32:3013-3016
The mixed disulfides from (R,S)-l-(Cbz-L-alanyloxy)-9-mercapto-phenoxatiin-10-sulfoxide and H-L-Cys-OMe undergo O,N-acyl transfer in DMSO at 23°C with rate constants of 7.0 h−1 and 0.048 h−1, and a rate ratio of 146; EM values of 0.2 M and 0.001
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea87028f3a347f5dcd796c735133f38d
https://doi.org/10.1016/0040-4039(91)80674-u
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10
Synthesis and conformational analysis of epindolidione-derived peptide models for .beta.-sheet formation
Autor: Christopher C. Muendel, D. S. Kemp, Benjamin R. Bowen
Publikováno v: The Journal of Organic Chemistry. 55:4650-4657
Synthesis of 2,8-diaminoepindolidione (2,8-diaminodibenzo [b,g] [1,5] naphthyridine-6,12(5,11H)-dione) in 19% yield from p-nitroaniline is reported, as well as further conversion to 2,8-bis(Boc-L-Pro-Xxx) epindolidione (Xxx=Gly, D-Ala) and then to 2,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::281a5f7a6b2bee3e5ae7a136bb308fb4
https://doi.org/10.1021/jo00302a033
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