Zobrazeno 1 - 10
of 541
pro vyhledávání: '"D. Ridgway"'
Autor:
Michael McPhee, Jonghwa Lee, Jayme Salsman, Marinella Pinelli, Francesca Di Cara, Kirill Rosen, Graham Dellaire, Neale D. Ridgway
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 5, Pp 100540- (2024)
Intestinal epithelial cells convert excess fatty acids into triglyceride (TAG) for storage in cytoplasmic lipid droplets and secretion in chylomicrons. Nuclear lipid droplets (nLDs) are present in intestinal cells but their origin and relationship to
Externí odkaz:
https://doaj.org/article/7c3632dc14df4cafbcfc4d155a46f03c
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303500 (2024)
Untargeted metabolomics investigations have characterized metabolic disturbances associated with various diseases in domestic cats. However, the pre-analytic stability of serum metabolites in the species is unknown. Our objective was to compare serum
Externí odkaz:
https://doaj.org/article/191f4d4f9e2d4f3fb58cf199965585bf
Autor:
Patrick C. Barko, Stanley I. Rubin, Kelly S. Swanson, Maureen A. McMichael, Marcella D. Ridgway, David A. Williams
Publikováno v:
Animals, Vol 13, Iss 14, p 2313 (2023)
Exocrine pancreatic insufficiency (EPI) is a malabsorptive syndrome resulting from insufficient secretion of pancreatic digestive enzymes. EPI is treated with pancreatic enzyme replacement therapy (PERT), but the persistence of clinical signs, especi
Externí odkaz:
https://doaj.org/article/e72fba446aa9418799618d5f967f067f
Autor:
Michael J. McPhee, Jayme Salsman, Jason Foster, Jordan Thompson, Sabateeshan Mathavarajah, Graham Dellaire, Neale D. Ridgway
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The nucleus harbours numerous protein subdomains and condensates that regulate chromatin organization, gene expression and genomic stress. A novel nuclear subdomain that is formed following exposure of cells to excess fatty acids is the nuclear lipid
Externí odkaz:
https://doaj.org/article/8bce2bba10a94b29ac182e66f19d8df8
Autor:
Gabriel G. Dorighello, Leandro H. P. Assis, Thiago Rentz, Joseane Morari, Monique F. M. Santana, Marisa Passarelli, Neale D. Ridgway, Anibal E. Vercesi, Helena C. F. Oliveira
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1734 (2022)
Plasma cholesteryl ester transfer protein (CETP) activity diminishes HDL-cholesterol levels and thus may increase atherosclerosis risk. Experimental evidence suggests CETP may also exhibit anti-inflammatory properties, but local tissue-specific funct
Externí odkaz:
https://doaj.org/article/a479ef00329548a4961a129e0c26d3d6
Autor:
Jonghwa Lee, Neale D. Ridgway
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1940-1950 (2018)
Intracellular lipid droplets (LDs) supply fatty acids for energy, membrane biogenesis, and lipoprotein secretion. The surface monolayer of LDs is composed of phospholipids, primarily phosphatidylcholine (PC), that stabilize the neutral lipid core of
Externí odkaz:
https://doaj.org/article/e0608a9d7e31476caecfc3cf25a983ac
Autor:
Kexin Zhao, Neale D. Ridgway
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1807-1818 (2017)
Lipoprotein cholesterol is delivered to the limiting membrane of late endosomes/lysosomes (LELs) by Niemann-Pick C1 (NPC1). However, the mechanism of cholesterol transport from LELs to the endoplasmic reticulum (ER) is poorly characterized. We report
Externí odkaz:
https://doaj.org/article/7041239d5bf141eab0ab20101b33159a
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214768 (2019)
The family of oxysterol binding protein (OSBP) and OSBP-related proteins (ORPs) mediate sterol and phospholipid transfer and signaling at membrane contact sites (MCS). The activity of OSBP at MCS is regulated by phosphorylation, but whether this appl
Externí odkaz:
https://doaj.org/article/178828d47b3a48739465d0b6f46640d7
Supplemental Figure 1. A. Western blot of purified preparations of human latent and active HPSE recombinant proteins showing distinct molecular weights, β-actin was probed as a loading control. M.W. standards were run in parallel with samples (left
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ecfcecd536495e05e1abc77d74036a
https://doi.org/10.1158/1541-7786.22517535.v1
https://doi.org/10.1158/1541-7786.22517535.v1
Autor:
Wai K. Allen, Kenneth D. Ridgway, J.A. Benowitz, T.S. Waldien, S.M. Roeske, P.G. Fitzgerald, R.J. Gillis
Publikováno v:
Geosphere. 18:585-615
Analysis of the late Miocene to Holocene McCallum sedimentary basin, located along the south side of the eastern Denali fault system, provides a better understanding of strike-slip basin evolution, timing of displacement on the Denali fault, and tect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe62c44a6f1ede6ced7282a3bd3e105a
https://doi.org/10.1130/ges02435.1
https://doi.org/10.1130/ges02435.1