Zobrazeno 1 - 10
of 54
pro vyhledávání: '"D. Reymen"'
Publikováno v:
Antiviral Research. 28:343-357
Human herpesvirus 6 (HHV-6) was examined in vitro for its sensitivity to a broad range of nucleoside analogues, including acyclovir (ACV), ganciclovir (GCV), penciclovir (PCV), buciclovir (BCV), brivudin (BVDU), the N7-isomer of 6-deoxyganciclovir (S
Autor:
Dominique Schols, Jacqueline Jozefonvicz, E. De Clercq, Graciela Andrei, P. McKenna, S. Ikeda, D. Reymen, José A. Esté, Myriam Witvrouw, Jan Clement, Johan Neyts, Didier Letourneur
Publikováno v:
Biochemical Pharmacology. 50:743-751
The antiviral activity of water-soluble dextrans derivatized with varying percentages of carboxymethyl, benzylamide, and sulfonate groups was evaluated. Several of the polymers exhibited potent antiviral activity against a variety of enveloped viruse
Autor:
S. Ikeda, Jean-Pierre Roque, Alain Leydet, Ph. Barthelemy, Robert Snoeck, Bernard Boyer, Anne Bousseau, D. Reymen, Michel Dr Evers, Gérard Lamaty, Y. Henin, E. De Clercq
Publikováno v:
Journal of Medicinal Chemistry. 38:2433-2440
A series of polyanionic compounds was synthesized and evaluated for their activity against human immunodeficiency virus (HIV-1, HIV-2) and various other RNA and DNA viruses. Several compounds, i.e., 2p, 3p, 8p, 13p, 14p, 15p, 17p, 18p, and 19p, prove
Autor:
E. De Clercq, Myriam Witvrouw, Pinglang Wang, D. Reymen, Johan Neyts, Mark Cushman, José A. Esté
Publikováno v:
Antiviral Chemistry and Chemotherapy. 6:179-186
A variety of aurintricarboxylic acid (ATA) polymer analogues were prepared by substituting certain salicylic acid derivatives and carbonyl compounds for salicylic acid and formaldehyde in the ATA polymerization reaction. The new polymers were evaluat
Autor:
E. De Clercq, Robert Snoeck, Graciela Andrei, D. Reymen, Jan Desmyter, Corinne Liesnard, P. Goubau
Publikováno v:
European Journal of Clinical Microbiology and Infectious Diseases. 14:318-329
Sixteen freshly isolated varicella-zoster virus (VZV) strains were evaluated in vitro, in parallel with two reference strains expressing a functional thymidine kinase (TK+) (Oka and YS) and two thymidine kinase-deficient mutants (TK-) (07-1 and YS-R)
Autor:
D. Reymen, Abhijit Mazumder, Lisa Graham, E. De Clercq, Yves Pommier, W. G. Rice, W. M. Golebiewski, Mark Cushman
Publikováno v:
Journal of Medicinal Chemistry. 38:443-452
Several new analogues of the novel anti-HIV agent cosalane have been synthesized and evaluated as inhibitors of HIV-1 integrase and protease, HIV-1 replication, HIV-1 and HIV-2 cytopathicity, HIV-1- and HIV-2-mediated syncytium formation, and cytopat
Autor:
N. V. Bianchini, E. De Clercq, S. Ikeda, Graciela Andrei, M. Q. Mateu, Rudi Pauwels, D. Reymen, Robert Snoeck, Jan Desmyter, Myriam Witvrouw, José A. Esté
Publikováno v:
Antiviral Chemistry and Chemotherapy. 5:297-303
A galactan sulfate (GS) was isolated from an aqueous extract of the red seaweed Aghardhiella tenera and partially purified. GS inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) in MT-4 cells at concentr
Publikováno v:
Antiviral Chemistry and Chemotherapy. 5:312-321
Dypiridamole (DPM) is widely used in the treatment of cardiovascular diseases as a coronary vasodilator and inhibitor of platelet aggregation. Phosphonylmethoxyethyl (PME) and 3-hydroxy-2-phosphonylmethoxypropyl (HPMP) derivatives of purines and pyri
Autor:
Rudi Pauwels, D. Reymen, Myriam Witvrouw, E. De Clercq, N Yamamoto, Jan Desmyter, Anne-Mieke Vandamme, Dominique Schols
Publikováno v:
Scopus-Elsevier
The drug Ro5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodiazepin-2(H)-one] inhibits human immunodeficiency virus type 1 (HIV-1) gene expression at the transcriptional level through interference with Tat-mediated transactivation (M.-C. Hsu, A. D. Schutt,
Autor:
M.E. Kuipers, E. De Clercq, Pieter Swart, Myriam Witvrouw, D. Reymen, Dirk K. F. Meijer, José A. Esté
Publikováno v:
Journal of drug targeting. 6(5)
Negatively charged albumins (NCAs, with the prototypes Suc-HSA and Aco-HSA), modified proteins with a potent anti-HIV-1 activity in the nanomolar concentration range, were studied for several aspects of their antiviral mechanism. In addition we inves