Zobrazeno 1 - 10
of 83
pro vyhledávání: '"D. Rainbow"'
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/b2ac73eace7a4afdace78a5204c0e525
Autor:
Sean Brennan, Simona Esposito, Muhammad I. M. Abdelaziz, Christopher A. Martin, Samir Makwana, Mark W. Sims, Iain B. Squire, Parveen Sharma, Amy E. Chadwick, Richard D. Rainbow
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Hyperglycaemia at the time of myocardial infarction has an adverse effect on prognosis irrespective of a prior diagnosis of diabetes, suggesting glucose is the damaging factor. In ex vivo models of ischaemia, we demonstrated that deleterious effects
Externí odkaz:
https://doaj.org/article/61cc3fe6d8c84613ac2712b76fa236b6
Autor:
Sean Brennan, Abrar I M Alnaimi, Lauren R McGuinness, Muhammad I M Abdelaziz, Robert A McKenzie, Sophie Draycott, Jacob Whitmore, Parveen Sharma, Richard D Rainbow
Publikováno v:
PNAS Nexus. 2
Cardiovascular disease is thought to account for nearly a third of deaths worldwide, with ischemic heart disease, including acute coronary syndromes such as myocardial infarction, accounting for 1.7 million deaths per year. There is a clear need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c27bd96072073e43b31b7d098f31a067
https://doi.org/10.1093/pnasnexus/pgad156
https://doi.org/10.1093/pnasnexus/pgad156
Publikováno v:
International Journal of Molecular Sciences. 24:6723
Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact on morbidity and mortality. The pathophysiology driving the development of these conditions is multifactorial but commonly includes the perturbance of reactive o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd8b407739131a41ef6623a2ed87d605
https://doi.org/10.3390/ijms24076723
https://doi.org/10.3390/ijms24076723
Autor:
Gavin E. Morris, Matthew J. Denniff, Elisavet Karamanavi, Sarah A. Andrews, Renata B. Kostogrys, Vasiliki Bountziouka, Maryam Ghaderi‐Najafabadi, Noor Shamkhi, George McConnell, Michael A. Kaiser, Laura Carleton, Christine Schofield, Thorsten Kessler, Richard D. Rainbow, Nilesh J. Samani, Thomas R. Webb
Publikováno v:
British journal of pharmacology. 179(21)
Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells (VSMCs). Several integrins directly modulate VSMC contraction by regulating calcium influx through L-type voltage-gated CaSVEP1 and integrin binding were con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732d606e6ed84edb06800a5b26403708
https://pubmed.ncbi.nlm.nih.gov/35802072
https://pubmed.ncbi.nlm.nih.gov/35802072
Autor:
David Lodwick, Saba Imanzadeh, Richard D. Rainbow, Ruth Reid, Robert I. Norman, Sean Brennan, Hussein N. Rubaiy
Publikováno v:
Biochemical Journal
BIOCHEMICAL JOURNAL
BIOCHEMICAL JOURNAL
ATP-sensitive potassium (KATP) channels are widely expressed and play key roles in many tissues by coupling metabolic state to membrane excitability. The SUR subunits confer drug and enhanced nucleotide sensitivity to the pore-forming Kir6 subunit, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523b6462339a0059014580e59723356a
https://doi.org/10.1042/bcj20190753
https://doi.org/10.1042/bcj20190753
Akademický článek
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Autor:
Richard D. Rainbow, Shen Chen, Sean Brennan, Asma S.A. Alonazi, Iain B. Squire, Christopher A Martin, Mark W Sims, Samir Makwana, Jonathan M. Willets
Publikováno v:
JOURNAL OF PHYSIOLOGY-LONDON
Key points Acute hyperglycaemia at the time of a heart attack worsens the outcome for the patient. Acute hyperglycaemia is not limited to diabetic patients and can be due to a stress response in non-diabetics. This study suggests that the damaging ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98362b706661f2daa176c94e2b9ff3ca
https://doi.org/10.1113/jp278332
https://doi.org/10.1113/jp278332
Autor:
Numan Celik, Sean Brennan, Caroline Dart, Richard Barrett-Jolley, Yalin Zheng, Frans Coenen, Richard D. Rainbow, Fiona O'Brien
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-10 (2020)
Single-molecule research techniques such as patch-clamp electrophysiology deliver unique biological insight by capturing the movement of individual proteins in real time, unobscured by whole-cell ensemble averaging. The critical first step in analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e05582d4e0211020d935ddb2803394
http://livrepository.liverpool.ac.uk/3065604/1/MS_AIP2_19-1074_1575579916_1_R4FOB.pdf
http://livrepository.liverpool.ac.uk/3065604/1/MS_AIP2_19-1074_1575579916_1_R4FOB.pdf
Autor:
Richard D. Rainbow, Jonathon M. Willets, John J.G. Tesmer, R. A. John Challiss, Robert Jackson, Sean Brennan, Helen V. Waldschmidt, Amal Bengreed, Alison J. Beech
Publikováno v:
Molecular pharmacology. 94(3)
Vasoconstrictor-driven G protein–coupled receptor (GPCR)/phospholipase C (PLC) signaling increases intracellular Ca(2+) concentration to mediate arterial contraction. To counteract vasoconstrictor-induced contraction, GPCR/PLC signaling can be dese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d17eecb916dcd897e26b072737ef95
https://pubmed.ncbi.nlm.nih.gov/29980659
https://pubmed.ncbi.nlm.nih.gov/29980659