Výsledky vyhledávání - "D. R. de Waart"

Influence of biliary cirrhosis on the detoxification and elimination of a food derived carcinogen

Autor: D. R. de Waart, R.O. Elferink, Hermann E. Wasmuth, Andreas Geier, Carsten Gartung, Christoph G. Dietrich, S. Matern

Publikováno v: Gut, 53(12), 1850-1855. BMJ Publishing Group

Background and aims: The liver is the central organ for the detoxification of numerous xenobiotics, including carcinogens. We studied the influence of cholestasis and biliary cirrhosis on the detoxification, elimination, and tissue distribution of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4926004900959c261f6f6efc25969abc
https://doi.org/10.1136/gut.2003.037507

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Combined Activity of NTCP and OATPS Governs Hepatic Uptake of Conjugated Bile Acids in Vivo

Autor: U. Beuers, R.O. Elferink, A.H. Schinkel, S. van de Graaf, D. R. de Waart, Dagmar Tolenaars, Davor Slijepcevic

Publikováno v: Journal of Hepatology. 64:S685-S686

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f4da543967031b10924d5c4feb02952
https://doi.org/10.1016/s0168-8278(16)01304-0

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Role of MRP2 and GSH in intrahepatic cycling of toxins

Autor: Roelof Ottenhoff, R P Oude Elferink, D. R. de Waart, Christoph G. Dietrich

Publikováno v: Toxicology, 167(1), 73-81. Elsevier Ireland Ltd

MRP2 is a canalicular transporter in hepatocytes mediating the transport of a wide spectrum of amphipathic compounds. This includes organic anions but also compounds complexed with GSH as, e.g. alpha-naphthylisothiocyanate (ANIT) and arsenite. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc24812d57fe09eceac22cde423ec9f
https://doi.org/10.1016/s0300-483x(01)00459-0

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In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV

Autor: Piter J. Bosma, Virginie Pichard, Suzanne Duijst, Nicolas Ferry, Dominique Aubert, Paula S. Montenegro-Miranda, L Ten Bloemendaal, D R de Waart

Publikováno v: Gene therapy, 21(2), 168-174. Nature Publishing Group

Adenoviral (AdV) and Adenovirus-associated viral (AAV) vectors both are used for in vivo gene therapy of inherited liver disorders, such as Crigler-Najjar syndrome type 1. In a relevant animal model, the Gunn rat, both vectors efficiently correct the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7502a82c16479084a47ec22359c3852e
https://pubmed.ncbi.nlm.nih.gov/24285217

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Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice

Autor: Renger F. Witkamp, Guido J. E. J. Hooiveld, D. R. de Waart, Martijn B. Katan, R.P.J. Oude Elferink, S.T.J. van Cruchten, Cindy Kunne, Mark V. Boekschoten

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals, 38(4), 635-640. American Society for Pharmacology and Experimental Therapeutics
Drug Metabolism and Disposition, 38(4), 635-40. American Society for Pharmacology and Experimental Therapeutics
Drug Metabolism and Disposition, 38(4), 635-640
Drug Metabolism and Disposition 38 (2010) 4
Drug Metabolism and Disposition, 4, 38, 635-640
van Cruchten, S T, de Waart, D R, Kunne, C, Hooiveld, G J, Boekschoten, M V, Katan, M B, Elferink, R P & Witkamp, R F 2010, ' Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice. ', Drug Metabolism and Disposition, vol. 38, no. 4, pp. 635-40 . https://doi.org/10.1124/dmd.109.030213

Cafestol is a diterpene present in unfiltered coffees. It is the most potent cholesterol-elevating compound present in the human diet. However, the precise mechanisms underlying this effect are still unclear. In contrast, cafestol is also known as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03250a27e60f1a24b4eeebfd2cd3acb
https://pure.amc.nl/en/publications/absorption-distribution-and-biliary-excretion-of-cafestol-a-potent-cholesterolelevating-compound-in-unfiltered-coffees-in-mice(b996e910-c0a7-45bd-b406-4d6c4a3a55ed).html

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Creatinine clearance during cimetidine administration for measurement of glomerular filtration rate

Autor: D. R. De Waart, M. G. Koopman, B. A. C. Van Acker, Gerardus C.M. Koomen, L. Arisz

Publikováno v: Lancet, 340(8831), 1326-1329. Elsevier Limited

Creatinine clearance inaccurately estimates true glomerular filtration rate (GFR) because of tubular secretion of creatinine. We studied the ability of oral cimetidine, a blocker of tubular creatinine secretion, to improve the accuracy of measuring c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63898062edc3134ec9600a9164369c1e
https://doi.org/10.1016/0140-6736(92)92502-7

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