Zobrazeno 1 - 10 of 17 pro vyhledávání: '"D. R. Sliskovic"'
1
PBS-1086, A rel inhibitor of NF-κB, ameliorates collagen-induced arthritis in mice
Autor: Placido Bramanti, Jeffrey Meshulam, Maria Galuppo, D. R. Sliskovic, Kathryn Bobb, Jie Zhang, Daniela Impellizzeri, Dileep D. Monie, Salvatore Cuzzocrea, R. Di Paola, Emanuela Mazzon
Publikováno v: European Journal of Inflammation, Vol 10 (2012)
The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the regulation of expression of numerous genes in the setting of the inflammatory response. Inflammation, cartilage degradation, cell proliferation, angiogen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85aeb6af2acfffd8cb619d92bf56d21
http://hdl.handle.net/11570/3092189
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2
Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. 8. Incorporation of Amide or Amine Functionalities into a Series of Disubstituted Ureas and Carbamates. Effects on ACAT Inhibition in vitro and Efficacy in vivo
Autor: C. J. Blankley, B.R. Krause, Patrick Michael O'brien, Michael William Wilson, K. L. Hamelehle, R. L. Stanfield, D. R. Sliskovic, Bruce David Roth
Publikováno v: Journal of Medicinal Chemistry. 37:1810-1822
A series of disubstituted ureas containing amide or amine groups was prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase in vitro and to lower plasma total cholesterol in a variety of cholesterol-fed rat models
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec94948a126f2e8cc31ae8279ce1bf13
https://doi.org/10.1021/jm00038a010
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5
Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus
Autor: Michael William Wilson, Milton L. Hoefle, D. R. Sliskovic, Roger S. Newton, Bruce D. Roth, Charlotte D. Stratton, Daniel F. Ortwine
Publikováno v: Journal of Medicinal Chemistry. 33:21-31
A novel series of trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones and their dihydroxy acid derivatives were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase in vitro. A systematic study of substitution at the 2- and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1694558173f4f71e10bcba1d30878f3
https://doi.org/10.1021/jm00163a005
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6
alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity
Autor: R. F. Bousley, Brian R. Krause, J. A. Picard, M. A. Anderson, K. L. Hamelehle, Reynold Homan, W. H. Roark, D. R. Sliskovic, D. Turluck, Bruce D. Roth, Sandra Bak Mueller, Thomas M.A. Bocan, R. L. Stanfield, P. Liao, Patrick Michael O'brien, J. F. Reindel
Publikováno v: Journal of medicinal chemistry. 41(5)
We prepared a series of alpha-substituted malonester amides that were evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase activity in vitro and to lower plasma total cholesterol levels in a variety of cholesterol-fed animal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f6d36491a2628448e75106d63c3636
https://pubmed.ncbi.nlm.nih.gov/9513596
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7
Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus
Autor: Bruce D. Roth, C. J. Blankley, Catherine Sekerke, E. Ferguson, A. W. Chucholowski, Milton L. Hoefle, Roger S. Newton, Charlotte D. Stratton, Daniel F. Ortwine, D. R. Sliskovic
Publikováno v: Journal of medicinal chemistry. 34(1)
A series of trans-tetrahydro-4-hydroxy-6-[2-(2,3,4,5-substituted-1H-pyrrol-1-yl) ethyl]-2H-pyran-2-ones and their dihydroxy acids were prepared and tested for their ability to inhibit the enzyme HMG-CoA reductase in vitro. Inhibitory potency was foun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cc1f80872bfb6e374a7d67e1aac12d
https://pubmed.ncbi.nlm.nih.gov/1992137
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