Zobrazeno 1 - 10
of 13
pro vyhledávání: '"D. R. Madden"'
Autor:
D. R. Madden, Don C. Wiley
Publikováno v:
Current Opinion in Structural Biology. 2:300-304
Each major histocompatibility complex molecule must bind any one of a large spectrum of peptides for presentation to the T cells of the immune system. Results on the sequences, biochemistry and three-dimensional structure of peptides bound to major h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34c8b0e17779b3cd444e0d827fcfa3cc
https://doi.org/10.1016/0959-440x(92)90161-y
https://doi.org/10.1016/0959-440x(92)90161-y
Publikováno v:
Proteins: Structure, Function, and Genetics. 12:87-90
The class I major histocompatibility (MHC) antigen HLA-B27 was purified by immunoaffinity chromatography from the homozygous human B lymphoblastoid cell line LG-2. Detergent-soluble HLA-B27 was cleaved with the protease papain to remove the hydrophob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0233bc8b5411f01d15b590e7196d9870
https://doi.org/10.1002/prot.340120110
https://doi.org/10.1002/prot.340120110
Publikováno v:
Nature. 353:326-329
A pool of endogenous peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified peptides provides information on the binding specificity of the HLA-B27 molecule. The peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad31e0aa28d50cfdeb7f3771a2ba1acc
https://doi.org/10.1038/353326a0
https://doi.org/10.1038/353326a0
Publikováno v:
European journal of biochemistry. 267(13)
The ionotropic glutamate receptors (GluR) are the primary mediators of excitatory synaptic transmission in the brain. GluR agonist binding has been localized to an extracellular domain whose core is homologous to the bacterial periplasmic binding pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e8c55d1b2c76a07ae4bf04030c0853e
https://pubmed.ncbi.nlm.nih.gov/10866833
https://pubmed.ncbi.nlm.nih.gov/10866833
Publikováno v:
The Journal of biological chemistry. 275(28)
Agonist binding to glutamate receptor ion channels occurs within an extracellular domain (S1S2) that retains ligand affinity when expressed separately. S1S2 is homologous to periplasmic binding proteins, and it has been proposed that a Venus flytrap-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dfddcb952d087180f479fa52a4104301
https://pubmed.ncbi.nlm.nih.gov/10748170
https://pubmed.ncbi.nlm.nih.gov/10748170
Publikováno v:
The Journal of biological chemistry. 273(39)
Redox agents elicit a wide variety of effects on the ligand affinity and channel properties of ionotropic glutamate receptors and have been proposed as potential therapeutic agents for neuropathological processes. One such effect is the dithiothreito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b852b34b7310fd80c697c92c92cb4f3a
https://pubmed.ncbi.nlm.nih.gov/9737972
https://pubmed.ncbi.nlm.nih.gov/9737972
Publikováno v:
Journal of molecular biology. 239(4)
We prepared and crystallized five complexes of the human histocompatibility molecule HLA-A2 with peptides derived from human immunodeficiency virus type 1, human T lymphotropic virus type 1, influenza A virus and hepatitis B virus proteins. Each HLA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fb01c1feccee45aa24c666ae83505ff
https://pubmed.ncbi.nlm.nih.gov/7516439
https://pubmed.ncbi.nlm.nih.gov/7516439
Autor:
Don C. Wiley, Theodore S. Jardetzky, Hwai-Chen Guo, Michael Silver, Jack L. Strominger, D. R. Madden, Joan C. Gorga
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 90(17)
Coordinates from x-ray structures of HLA-A*6801, HLA-A*0201, and HLA-B*2705 were analyzed to examine the basis for their selectivity in peptide binding. The pocket that binds the side chain of the peptide's second amino acid residue (P2 residue) show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cbacb5eb8b06ec6f01ed6b0722d875
https://pubmed.ncbi.nlm.nih.gov/8367462
https://pubmed.ncbi.nlm.nih.gov/8367462
Publikováno v:
Cell. 70(6)
Cell surface complexes of class I MHC molecules and bound peptide antigens serve as specific recognition elements controlling the cytotoxic immune response. The 2.1 A structure of the human class I MHC molecule HLA-B27 provides a detailed composite i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a501839c8f7afcee6a59950c4eddf0
https://pubmed.ncbi.nlm.nih.gov/1525820
https://pubmed.ncbi.nlm.nih.gov/1525820
Publikováno v:
Diabetologia. 32:236-239
We have analysed the results of urinary albumin excretion in timed overnight urine samples once every two weeks during pregnancy and post-natally in 25 non-diabetic women and 14 women with Type 1 (insulin-dependent) diabetes who were Albustix negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ed5b2fab9df74114c6190899a65339
https://doi.org/10.1007/bf00285290
https://doi.org/10.1007/bf00285290