Zobrazeno 1 - 10 of 56 pro vyhledávání: '"D. R. Lowy"'
2
Prevention of cancer through immunization: Prospects and challenges for the 21st century
Autor: John T. Schiller, Ian H. Frazer, D R Lowy
Publikováno v: European Journal of Immunology. 37:S148-S155
Persistent infection by several microbial agents is responsible for at least 15% of cancer globally, including most cancers of the liver, stomach, and cervix. The recent development of vaccines that can prevent infection and premalignant disease caus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a335aeba19306175cc03cd50f3fcde
https://doi.org/10.1002/eji.200737820
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4
Virus-like Particles of Bovine Papillomavirus Type 4 in Prophylactic and Therapeutic Immunization
Autor: A. Armstrong, Reinhard Kirnbauer, John T. Schiller, E. R. Wagner, Maria Saveria Campo, G.J. Grindlay, Gail M. McGarvie, B. W. O'Neil, L. M. Chandrachud, D R Lowy
Publikováno v: Virology. 219:37-44
Virus-like particles were produced in insect cells containing either the L1 and L2 capsid proteins of bovine papillomavirus type 4 (BPV-4) or only the L1 protein. Both preparations of VLPs proved to be extremely effective prophylactic vaccines. Thirt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8496cdf897ef57cc6282e0a9be4b7948
https://doi.org/10.1006/viro.1996.0220
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5
Neutralization of bovine papillomavirus by antibodies to L1 and L2 capsid proteins
Autor: E. M. Weissinger, Frank P. Booy, John T. Schiller, J. F. Mushinski, Reinhard Kirnbauer, D. W. Henderson, D R Lowy, Richard B.S. Roden
Publikováno v: Journal of Virology. 68:7570-7574
We have generated four mouse monoclonal antibodies (MAbs) to bovine papillomavirus virions that bound type-specific, adjacent, and conformationally dependent epitopes on the L1 major capsid protein. All four MAbs were neutralizing at ratios of 1 MAb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762722336342b1349be8e47655a99806
https://doi.org/10.1128/jvi.68.11.7570-7574.1994
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6
Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function
Autor: S. Felzmann, D R Lowy, Gangfeng Xu, M. R. Johnson, William C. Vass, R. White, Jeffrey E. DeClue
Publikováno v: Molecular and Cellular Biology. 14:641-645
The NF1 gene, which is altered in patients with type 1 neurofibromatosis, has been postulated to function as a tumor suppressor gene. The NF1 protein product neurofibromin stimulates the intrinsic GTPase activity of active GTP-bound Ras, thereby inac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562f6a7092ede973616ad99d96e78e10
https://doi.org/10.1128/mcb.14.1.641-645.1994
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7
Regulated and Constitutive Activity by CDC25Mm (GRF), a Ras-Specific Exchange Factor
Autor: Ke Zhang, Hui Cen, D R Lowy, William C. Vass, Alex G. Papageorge
Publikováno v: Molecular and Cellular Biology. 13:7718-7724
Serum stimulates cells to increase their proportion of Ras protein in the active GTP-bound state. We have recently identified four types (I to IV) of apparently full-length cDNAs from a single mammalian gene, called CDC25Mm or GRF, which is homologou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b167e23abb6c1eb6cd5317eeeb1e39d
https://doi.org/10.1128/mcb.13.12.7718-7724.1993
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8
Functional role of GTPase-activating protein in cell transformation by pp60v-src
Autor: J E DeClue, W C Vass, M R Johnson, D W Stacey, D R Lowy
Publikováno v: Molecular and Cellular Biology. 13:6799-6809
Morphological transformation of NIH 3T3 cells was observed following coexpression of a portion of the ras GTPase-activating protein (GAP) comprising the amino terminus (GAP-N) and a mutant of v-src (MDSRC) lacking the membrane-localizing sequence. Ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aef1e1fdf82a1a71eda3e9a9c6c8a6aa
https://doi.org/10.1128/mcb.13.11.6799
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9
Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity
Autor: John T. Schiller, William C. Vass, Nancy L. Hubbert, S A Sedman, D R Lowy
Publikováno v: Journal of Virology. 66:4201-4208
Human papillomavirus type 16 (HPV16) E6 and E7 are selectively retained and expressed in HPV16-associated human genital tumors. E6 is active in several cell culture assays, including transformation of NIH 3T3 cells, trans activation of the adenovirus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f1340430f2311ac9ebc13fdc1943e5
https://doi.org/10.1128/jvi.66.7.4201-4208.1992
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10
The Bovine Papillomavirus E5 Oncogene Can Cooperate with ras: Identification of p21 Amino Acids Critical for Transformation by c-rasH but Not v-rasH
Autor: B M, Willumsen, W C, Vass, T J, Velu, A G, Papageorge, J T, Schiller, D R, Lowy
Publikováno v: Molecular and Cellular Biology. 11:6026-6033
We have previously used a series of insertion-deletion mutants of the mutationally activated v-rasH gene to identify several regions of the encoded protein that are dispensable for cellular transformation (B. M. Willumsen, A. G. Papageorge, H.-F. Kun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7414aaefea90f42b1a3b8749a8ee5c12
https://doi.org/10.1128/mcb.11.12.6026-6033.1991
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