Zobrazeno 1 - 10
of 23
pro vyhledávání: '"D. R. Germolec"'
Autor:
J. M. Kim, J. P. Kosak, J. K. Kim, G. Kissling, D. R. Germolec, D. C. Zeldin, J. A. Bradbury, S. J. Baek, T. E. Eling
Publikováno v:
Mediators of Inflammation, Vol 2013 (2013)
NAG-1/GDF15 is a TGF-β superfamily member with poorly characterized biological activity proposed to inhibit inflammatory cytokine production. Transgenic mice expressing human NAG-1/GDF15 (NAG-1Tg/Lox) are leaner with lower body weight and are resist
Externí odkaz:
https://doaj.org/article/f0a26459bd734d339b1985efccb700c8
Autor:
N. A. Karrow, J. A. McCay, R. D. Brown, D. L. Musgrove, D. R. Germolec, K. L. White, Kimber L. White
Publikováno v:
Drug and Chemical Toxicology. 24:19-37
The macrolide antibiotic, clarithromycin, is used extensively to treat bacterial infections associated with pneumonia, duodenal ulcers, and the advanced stages of human immunodeficiency viral (HIV) infection. In addition to its antimicrobial properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9b4f86cac9b4541cfa11d7513d3774
https://doi.org/10.1081/dct-100103083
https://doi.org/10.1081/dct-100103083
Publikováno v:
Carcinogenesis. 18:1453-1456
WY-14,643 [4-chloro-6-(2,3-xylidino)pyrimidinylthio-acetic acid] is a well-known non-genotoxic carcinogen and peroxisome proliferator that causes liver cancer in rodents by unknown mechanisms. Its ability to sustain elevated rates of hepatocyte DNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165b5068f74f40bcbdebdcb68faca22b
https://doi.org/10.1093/carcin/18.8.1453
https://doi.org/10.1093/carcin/18.8.1453
Autor:
P. Simeonova, D R Germolec, Alessandra Bruccoleri, Robert Schoonhoven, Heidi K. Bojes, M I Luster, Ronald G. Thurman
Publikováno v:
Carcinogenesis. 18:669-674
Several structurally dissimilar hypolipidemic drugs, plasticizers and halogenated hydrocarbons induce peroxisomes in hepatocytes, and cause hepatocellular adenoma and carcinoma in rats and mice. The mechanism by which these agents act is unknown, alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618bd2cb983ce877261bc99268215004
https://doi.org/10.1093/carcin/18.4.669
https://doi.org/10.1093/carcin/18.4.669
Autor:
G J Rosenthal, D R Germolec, M E Blazka, E Corsini, P Simeonova, P Pollock, L Y Kong, J Kwon, M I Luster
Publikováno v:
The Journal of Immunology. 153:3237-3244
Studies have indicated that soluble products, including chemotactic factors, released by activated lung macrophages and fibroblasts are critical mediators in the pathogenesis of asbestos-induced pulmonary fibrosis. We provide evidence that mediators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::582e1814f8afe1fcd9eeaa10b5830311
https://doi.org/10.4049/jimmunol.153.7.3237
https://doi.org/10.4049/jimmunol.153.7.3237
Autor:
D R, Germolec
Publikováno v:
Methods in molecular medicine. 22
Immunoassays are techniques for measuring the concentration or activity of a substance using immunological reactions. Several types of immunoassay are commonly used, including precipitation assays using antibody/antigen complexes, agglutination assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7de0816c412f201d7f72944fb0ee242e
https://pubmed.ncbi.nlm.nih.gov/21380835
https://pubmed.ncbi.nlm.nih.gov/21380835
Autor:
K. J. Trouba, D. R. Germolec
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 79(2)
Based on evidence that arsenic modulates proinflammatory events that are involved in skin carcinogenecity, we hypothesized that in normal human epidermal keratinocytes (NHEK) arsenic increases expression of the procarcinogenic enzyme cyclooxygenase-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e211b77237155c3cfe689f7752ebfd0
https://pubmed.ncbi.nlm.nih.gov/15056798
https://pubmed.ncbi.nlm.nih.gov/15056798
Publikováno v:
American journal of contact dermatitis : official journal of the American Contact Dermatitis Society. 13(3)
Sodium metasilicate (SMS) is a key ingredient for a number of industrial and consumer products. Although little is known about potential for this chemical to cause allergic reactions, a similar silicate compound, sodium silicate, was reported to elic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c15312f9e37dbec29c74f45b2342074e
https://pubmed.ncbi.nlm.nih.gov/12165932
https://pubmed.ncbi.nlm.nih.gov/12165932
Autor:
D R, Germolec, T, Yoshida, K, Gaido, J L, Wilmer, P P, Simeonova, F, Kayama, F, Burleson, W, Dong, R W, Lange, M I, Luster
Publikováno v:
Toxicology and applied pharmacology. 141(1)
Although epidemiological studies have shown that inorganic arsenicals are human skin carcinogens and induce hyperproliferation and hyperkeratosis, there is currently no known mechanism for their action or an established animal model for its study. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0f034151ef5ed180008572d3264cf58
https://pubmed.ncbi.nlm.nih.gov/8917704
https://pubmed.ncbi.nlm.nih.gov/8917704
Publikováno v:
Research communications in molecular pathology and pharmacology. 93(2)
In many organ/tissues rapid and transient increases in early-immediate gene responses, such as those that encode for the AP-1 family of transcription factors, occur in response to exogenous stimuli. Activation of AP-1, in turn, helps regulate the exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8df72fdac956902ee6f614f53d21fbab
https://pubmed.ncbi.nlm.nih.gov/8884985
https://pubmed.ncbi.nlm.nih.gov/8884985