Zobrazeno 1 - 10
of 22
pro vyhledávání: '"D. R. Buckle"'
Autor:
D R, Buckle, J R, Arch, C, Edge, K A, Foster, C S, Houge-Frydrych, I L, Pinto, D G, Smith, J F, Taylor, S G, Taylor, J M, Tedder
Publikováno v:
Journal of Medicinal Chemistry. 34:919-926
The synthesis of a novel series of smooth muscle relaxants which have been shown to act via the opening or activation of potassium channels is described. Compounds have been evaluated for their ability to inhibit spontaneous tone in guinea pig isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7224b6f41aa054254791130b3ad370c
https://doi.org/10.1021/jm00107a008
https://doi.org/10.1021/jm00107a008
Autor:
D R, Buckle
Publikováno v:
IDrugs : the investigational drugs journal. 1(2)
This symposium, organized jointly by the Royal Society of Chemistry and the Society of Chemical Industry, aimed to distil current knowledge on the classification, structure and mechanism of proteolytic enzymes whilst focusing on the approaches and me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47b5cefb8f76dd0f1efe3fc976fde379
https://pubmed.ncbi.nlm.nih.gov/18465527
https://pubmed.ncbi.nlm.nih.gov/18465527
Autor:
D R, Buckle
Publikováno v:
IDrugs : the investigational drugs journal. 1(8)
This report summarizes the glycochemistry and glycobiology session held on the fourth day of this international symposium organized under the auspices of the European Federation of Medicinal Chemistry. The session objective was to highlight and empha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a77da7000dd9694bccabe4d7ae528fd
https://pubmed.ncbi.nlm.nih.gov/16196473
https://pubmed.ncbi.nlm.nih.gov/16196473
Autor:
D R, Buckle
Publikováno v:
IDrugs : the investigational drugs journal. 1(8)
This report summarizes the new technologies in drug discovery session of a five-day symposium organized by the Royal Society of Chemistry, Perkin Division, and the Biological and Medicinal Chemistry Sector of the Industrial Affairs Division on behalf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::565baf474bea85a333333a4ada365b84
https://pubmed.ncbi.nlm.nih.gov/16196472
https://pubmed.ncbi.nlm.nih.gov/16196472
Autor:
P W, Young, D R, Buckle, B C, Cantello, H, Chapman, J C, Clapham, P J, Coyle, D, Haigh, R M, Hindley, J C, Holder, H, Kallender, A J, Latter, K W, Lawrie, D, Mossakowska, G J, Murphy, L, Roxbee Cox, S A, Smith
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(2)
A radioiodinated ligand, [125I]SB-236636 [(S)-(-)3-[4-[2-[N-(2-benzoxazolyl)-N-methylamino]ethoxy]3-[125I]i odo phenyl]2-ethoxy propanoic acid], which is specific for the gamma isoform of the peroxisomal proliferator activated receptor (PPARgamma), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5984f2e2312eaa72d795ae41338b061
https://pubmed.ncbi.nlm.nih.gov/9454824
https://pubmed.ncbi.nlm.nih.gov/9454824
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 261(2)
The effects of the potassium channel activators, cromakalim, BRL 38227 and pinacidil, and the calcium antagonist, verapamil, have been compared against various spasmogens on airway responses in vitro and in vivo in the guinea pig and also in human is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f08aeede846313dd153e02b265d501f
https://pubmed.ncbi.nlm.nih.gov/1578358
https://pubmed.ncbi.nlm.nih.gov/1578358
Autor:
D R, Buckle, J F, Taylor
Publikováno v:
Agents and actions. Supplements. 34
The ability of the potassium channel activator cromakalim to relax smooth muscle of the airways is now well established. The compound has been shown to be an effective bronchodilator in animal models, and more importantly, to attenuate induced bronch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d8cf2edc3cda94821cedd4fdcbddfe0
https://pubmed.ncbi.nlm.nih.gov/1793078
https://pubmed.ncbi.nlm.nih.gov/1793078
Autor:
E. S. Waight, D. R. Buckle
Publikováno v:
Organic Mass Spectrometry. 2:367-373
The synthesis of dunnione (II) from 2-hydroxynaphtha-1,4-quinone has been improved and used to prepare three deuteriated analogues. The mass spectra of these compounds and of the products of their reductive acetylation and deuterioacetylation have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c08de765eb2ff9309bf91a16ff0b724
https://doi.org/10.1002/oms.1210020405
https://doi.org/10.1002/oms.1210020405
Autor:
E. S. Waight, D. R. Buckle
Publikováno v:
Organic Mass Spectrometry. 1:273-278
The mass spectra of 1-phenylanthra-9,10-quinone and 20 substituted l-phenylanthraquinones having alkyl methoxyl, nitro and halogen substituents in the o-, m- and p-positions of the phenyl ring have been measured. The spectra are discussed with partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6db1921e6b29864692a695912bd56ce6
https://doi.org/10.1002/oms.1210010209
https://doi.org/10.1002/oms.1210010209
Autor:
J. M. Tedder, D. R. Buckle
Publikováno v:
Chemischer Informationsdienst. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bacf1938a1dcd0f9c4c6e6725901f126
https://doi.org/10.1002/chin.198318076
https://doi.org/10.1002/chin.198318076