Výsledky vyhledávání - "D. R. A. Mans"

Phase I Study of Three-Times Daily Oral Etoposide in Patients with Refractory Solid Tumours

Autor: E. Sander, Ana Paula Ferrary Caldas, Anna Isabel Neto Cancela, Holger J. Schünemann, A. F. Ferreira Filho, D. R. A. Mans, L. Di Leone, O. Campos Junior, T. Dalla Costa, Gilberto Schwartsmann

Publikováno v: Scopus-Elsevier

Objective: The objective of this phase I study of oral etoposide in patients with refractory solid tumours was to determine the tolerability and pharmacokinetic profile and to establish the maximum tolerated dose (MTD) of the drug for this indication

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ca8c97093840e7d102194d8977e819
https://doi.org/10.2165/00044011-200019050-00008

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A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer

Autor: C Garbino, Gilberto Schwartsmann, D. R. A. Mans, Holger J. Schünemann, C N Gorini, A F Filho, Luciane Pons DiLeone, G Sabini, I Muse

Publikováno v: Investigational new drugs. 18(1)

The authors describe a phase I trial of cisplatin plus decitabine, a novel DNA-hypomethylating agent, in patients with advanced solid tumors, which was followed by an early phase II evaluation of the combination in patients with inoperable non-small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54050faba0851cd92291e1e96ccf5322
https://pubmed.ncbi.nlm.nih.gov/10830142

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Clinical and pharmacokinetic study of oral etoposide in patients with AIDS-related Kaposi's sarcoma with no prior exposure to cytotoxic therapy

Autor: L. Di Leone, Luciane Kalakun, E. Sander, D. R. A. Mans, Gilberto Schwartsmann, M. Kromfield, Eduardo Sprinz, G. Prolla, L M Gerhardt

Publikováno v: Scopus-Elsevier

PURPOSE In this phase II and pharmacokinetic study, chronic, low-dose, oral etoposide was evaluated for its efficacy in patients with AIDS-related Kaposi's sarcoma who were not previously exposed to cytotoxic therapy. PATIENTS AND METHODS Of 28 patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0314f257cd60e24f01f24db2e7d195eb
https://pubmed.ncbi.nlm.nih.gov/9164226

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The effect of reduced neopterin on the synthesis of several methylated indoles in the pineal gland of adult male golden hamsters, kept under standardized conditions

Autor: D. R. A. Mans, J. van Benthem, M. G. M. Balemans, A. de Morée, I. Ebels

Publikováno v: Journal of Neural Transmission. 62:137-154

In the present study the effect was tested of reduced neopterin (RN) on the methylating capacity of the pineal gland of adult, male golden hamsters, housed under standardized conditions throughout the year. An effect of RN on the synthesis of a numbe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84443d3eccb48f7121807f08a3f8defc
https://doi.org/10.1007/bf01260423

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Rhythmic synthesis of various 5-methoxyindoles in the pineal gland of male adult golden hamsters, kept under the same artificial conditions throughout the year

Autor: D. R. A. Mans, J. van Benthem, M. G. M. Balemans, I. Ebels

Publikováno v: Journal of Neural Transmission. 61:219-237

Until now the day/night and seasonal rhythmicity in the synthesis of 5-methoxyindoles (MI) is thought to be regulated by environmental factors, especially photoperiod and temperature. Endogenous factors are also implicated in the generation of N-acet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fcb53d3a9fdc343d5c168eb37cef5e
https://doi.org/10.1007/bf01251914

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Daily and seasonal rhythmicity in the methylation of pineal indolic compounds in adult male golden hamsters, kept under natural conditions

Autor: D. R. A. Mans, C. Haldar-Misra, I. Ebels, M. G. M. Balemans, J. van Benthem

Publikováno v: Journal of neural transmission. 64(3-4)

Seasonal rhythmicity in the reproductive cycle was demonstrated in golden hamsters exposed to natural conditions. Testes regress in weight and function from October up to April. Reproductive functional testes are found in June. Although less marked,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c6908180ad9f3efaef095b33d73530
https://pubmed.ncbi.nlm.nih.gov/4086993

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The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar rat

Autor: M. G. M. Balemans, I. Smith, D. R. A. Mans, J. van Benthem

Publikováno v: Reproduction, nutrition, developpement. 23(1)

The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol has been investigated using different experimental procedures. It was demonstrated that when GABA and an acetyl dono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d07cb6431e51a652317100abfde169
https://pubmed.ncbi.nlm.nih.gov/6844712

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Methoxyindole synthesis in the retina of the frog (Rana esculenta) during a diurnal period

Autor: W. F. G. Flight, M. G. M. Balemans, D. R. A. Mans

Publikováno v: Journal of neural transmission. 58(3-4)

In the present study, the synthesis of methoxyindoles in the neural part and in the pigment epithelial layer of the retina of the frog eye was investigated on the basis of naturally occurring substrate at regular intervals during a 24 hour period. Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c72982a2df277bc6cff2031d43c5a18
https://pubmed.ncbi.nlm.nih.gov/6198459

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