Výsledky vyhledávání

Akademický článek

Lipid composition and gonadotropin-mediated lipid metabolism of the M5480 murine Leydig cell tumor

Autor: D H Albert, M Ascoli, D Puett, J G Coniglio

Publikováno v: Journal of Lipid Research, Vol 21, Iss 7, Pp 862-867 (1980)

The effects of human choriogonadotropin (HCG) stimulation on lipid composition in the murine Leydig cell tumor M5480 grown subcutaneously were determined. The main lipids of the Leydig cell tumor were found to be largely triacylglycerols and phosphol

Externí odkaz: https://doaj.org/article/739bbe87a1b841f5b2c0bd8099b9fb1a

Zobrazit plný text záznamu

Site-directed mutagenesis of amino acids 33-44 of the common alpha-subunit reveals different structural requirements for heterodimer expression among the glycoprotein hormones and suggests that cyclic adenosine 3',5'-monophosphate production and growth promotion are potentially dissociable functions of human thyrotropin

Autor: J A Dias, H Xia, Bruce D. Weintraub, Mathis Grossmann, Rosemary Wong, D Puett, Mariusz W. Szkudlinski

Publikováno v: Molecular Endocrinology. 10:769-779

Amino acid residues 33-44 of the common alpha-subunit of the glycoprotein hormones have been implicated in heterodimerization as well as high affinity receptor binding of human (h) CG. In the present study, we compared the role of specific amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca98c11546517883fecc14dfa5cf79e
https://doi.org/10.1210/mend.10.6.8776737

Zobrazit plný text záznamu

A biologically active single chain human chorionic gonadotropin analog with altered receptor binding properties

Autor: P, Narayan, J, Gray, D, Puett

Publikováno v: Endocrinology. 141(1)

hCG is a heterodimer consisting of an alpha-subunit common among all members of the glycoprotein hormone family, LH, FSH, and TSH, and a unique beta-subunit responsible for receptor specificity. Biologically active single chain analogs of these hormo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2697c654638fd79aa81f8b91e11cb2b0
https://pubmed.ncbi.nlm.nih.gov/10614624

Zobrazit plný text záznamu

Identification of ionizable amino acid residues on the extracellular domain of the lutropin receptor involved in ligand binding

Autor: N, Bhowmick, P, Narayan, D, Puett

Publikováno v: Endocrinology. 140(10)

The LH receptor (LHR) is a G protein-coupled receptor characterized by a relatively large N-terminal extracellular domain responsible for high affinity ligand binding. Based on a model proposed for a major portion of the extracellular domain that con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26aa78af91a95e5419cac20afd39b45f
https://pubmed.ncbi.nlm.nih.gov/10499511

Zobrazit plný text záznamu

Surface retention of an inactivating lutropin receptor mutant in exoloop 3

Autor: N, Bhowmick, P, Narayan, D, Puett

Publikováno v: Molecular and cellular biochemistry. 187(1-2)

The heptahelical lutropin receptor (LHR) signals primarily via the Gs-adenylyl cyclase pathway and undergoes ligand-mediated receptor desensitization and internalization. A loss-of-function rat LHR mutant was recently described in which a single amin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ca9bf285e69a438156080eb5acc2d1d
https://pubmed.ncbi.nlm.nih.gov/9788760

Zobrazit plný text záznamu

The endothelin subtype A receptor undergoes agonist- and antagonist-mediated internalization in the absence of signaling

Autor: N, Bhowmick, P, Narayan, D, Puett

Publikováno v: Endocrinology. 139(7)

The potent vasoconstrictor and mitogen to smooth muscle cells, endothelin-1 (ET-1), acts via two distinct G protein-coupled receptors, subtype A (ETAR) and subtype B, that are coupled primarily to the Gq-phospholipase C signaling pathway. It is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbedaec4c32716bb8a4c3905cfb19231
https://pubmed.ncbi.nlm.nih.gov/9645692

Zobrazit plný text záznamu

The tie that binds: design of biologically active single-chain human chorionic gonadotropins and a gonadotropin-receptor complex using protein engineering

Autor: D, Puett, C, Wu, P, Narayan

Publikováno v: Biology of reproduction. 58(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8695d42bd47d57e8581df75a8a1d126
https://pubmed.ncbi.nlm.nih.gov/9623590

Zobrazit plný text záznamu

Gender differences in the expression of endothelin receptors in human saphenous veins in vitro

Autor: A, Ergul, K, Shoemaker, D, Puett, R L, Tackett

Publikováno v: The Journal of pharmacology and experimental therapeutics. 285(2)

The contractile response to endothelin-1 (ET-1) appears to be modulated by the relative density of ETA and ETB receptors. To determine the effects of gender on the distribution of ET receptors, we analyzed the endothelin receptor subtypes on membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::377c2ab11665902d28a97b5df11ef124
https://pubmed.ncbi.nlm.nih.gov/9580591

Zobrazit plný text záznamu

Endothelin binding to NG108-15 cells: evidence for conventional ETA and ETB receptor subtypes and super-high affinity binding components

Autor: K, Angelova, A, Ergul, P, Narayan, D, Puett

Publikováno v: Cellular and molecular biology (Noisy-le-Grand, France). 42(8)

The endothelin (ET) peptides have been identified in the CNS, but there is a paucity of information on their physiological roles. NG108-15 cells, a clonal strain of a neuroblastoma x glioma hybrid cell line, have been widely used in neurobiological r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::947f5497e5308496ddfef84ab992cfc8
https://pubmed.ncbi.nlm.nih.gov/8997527

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání