Zobrazeno 1 - 10
of 241
pro vyhledávání: '"D. Plowman"'
Autor:
Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar N. Haidar, Sylvie Moureau, Tomasz Dobrzycki, Conor Hayes, Christopher Rowley, Jorge Dias, Stephen Harper, Keir Barnbrook, Miriam Hock, Charlotte Coles, Wei Yang, Milos Aleksic, Aimee Bence Lin, Ross Robinson, Joe D. Dukes, Nathaniel Liddy, Marc Van der Kamp, Gregory D. Plowman, Annelise Vuidepot, David K. Cole, Andrew D. Whale, Chandramouli Chillakuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering
Externí odkaz:
https://doaj.org/article/d2f84672e7fe4eb3b7df368784cf9d36
Autor:
Rikke B. Holmgaard, David A. Schaer, Yanxia Li, Stephen P. Castaneda, Mary Y. Murphy, Xiaohong Xu, Ivan Inigo, Julie Dobkin, Jason R. Manro, Philip W. Iversen, David Surguladze, Gerald E. Hall, Ruslan D. Novosiadly, Karim A. Benhadji, Gregory D. Plowman, Michael Kalos, Kyla E. Driscoll
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background TGFβ signaling plays a pleotropic role in tumor biology, promoting tumor proliferation, invasion and metastasis, and escape from immune surveillance. Inhibiting TGFβ’s immune suppressive effects has become of particular intere
Externí odkaz:
https://doaj.org/article/add74ac3d1f847239e42c3dd99f9f142
Autor:
Michael Kalos, Dale L. Ludwig, Gregory D. Plowman, Christopher M. Moxham, Ruslan D. Novosiadly, Jaafar N. Haidar, Andreas Sonyi, Darin Chin, Stacy Torgerson, Bing Han, Yanbin Lao, Tim Bailey, Danielle K. Bulaon, Yiwei Zhang, Xinlei Chen, Michael Topper, Sagit Hindi, Krishnadatt Persaud, Anthony L. Pennello, David Surguladze, Ivan Inigo, George Wang, Yang Shen, Scott W. Eastman, Carmine Carpenito, Maria Malabunga, Yiwen Li, Helen Kotanides
The programmed cell death protein 1 receptor (PD-1) and programmed death ligand 1 (PD-L1) coinhibitory pathway suppresses T-cell–mediated immunity. We hypothesized that cotargeting of PD-1 and PD-L1 with a bispecific antibody molecule could provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1986ead76832948fc92b79c10618c0e0
https://doi.org/10.1158/2326-6066.c.6550090
https://doi.org/10.1158/2326-6066.c.6550090
Autor:
Michael Kalos, Dale L. Ludwig, Gregory D. Plowman, Christopher M. Moxham, Ruslan D. Novosiadly, Jaafar N. Haidar, Andreas Sonyi, Darin Chin, Stacy Torgerson, Bing Han, Yanbin Lao, Tim Bailey, Danielle K. Bulaon, Yiwei Zhang, Xinlei Chen, Michael Topper, Sagit Hindi, Krishnadatt Persaud, Anthony L. Pennello, David Surguladze, Ivan Inigo, George Wang, Yang Shen, Scott W. Eastman, Carmine Carpenito, Maria Malabunga, Yiwen Li, Helen Kotanides
Supplementary Figures 1-9 and Supplementary Tables 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae9b70f08e357e6f6d0737e3afa7b80
https://doi.org/10.1158/2326-6066.22542937.v1
https://doi.org/10.1158/2326-6066.22542937.v1
Autor:
Michael Kalos, Gregory D. Plowman, Dale L. Ludwig, Ruslan D. Novosiadly, Douglas Burtrum, Yiwei Zhang, Prachi Sharma, Lauren Boucher, Michael Topper, Andreas Sonyi, Darin Chin, Xinlei Chen, Amelie Forest, Anthony L. Pennello, Ivan Inigo, Leyi Shen, Colleen Burns, Jaafar N. Haidar, David Surguladze, Jingxing Li, Juqun Shen, Carmine Carpenito, Maria B. Lebron, Rose Marie Sattler, Helen Kotanides
Figure S9 shows antitumor efficacy of combination therapy in the L55 NSCLC tumor xenograft model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e0befc3cf257f3da5e314069cd7d7a
https://doi.org/10.1158/1535-7163.22519392.v1
https://doi.org/10.1158/1535-7163.22519392.v1
Autor:
Sheng-Bin Peng, Sajan Joseph, Ramon V. Tiu, Gregory D. Plowman, Michael J. Rodriguez, Eunice Yuen, Jennie Walgren, Jason Manro, Andrew J. Dropsey, Denis McCann, Xi Rao, Robert D. Van Horn, Meghann Pogue, Xiu-Juan Yuan, Yan Zhai, Bryan Anderson, Wenjuan Wu, Robert S. Flack, Lisa Kindler, Weihua Shen, Matthew Whitesell, Baohui Zhao, Shufen Cai, William T. McMillen, Shripad V. Bhagwat
The ERK pathway is critical in oncogenesis; aberrations in components of this pathway are common in approximately 30% of human cancers. ERK1/2 (ERK) regulates cell proliferation, differentiation, and survival and is the terminal node of the pathway.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b6b83642603b80faa51fcf05c737a2b
https://doi.org/10.1158/1535-7163.c.6538636.v1
https://doi.org/10.1158/1535-7163.c.6538636.v1
Autor:
Sheng-Bin Peng, Sajan Joseph, Ramon V. Tiu, Gregory D. Plowman, Michael J. Rodriguez, Eunice Yuen, Jennie Walgren, Jason Manro, Andrew J. Dropsey, Denis McCann, Xi Rao, Robert D. Van Horn, Meghann Pogue, Xiu-Juan Yuan, Yan Zhai, Bryan Anderson, Wenjuan Wu, Robert S. Flack, Lisa Kindler, Weihua Shen, Matthew Whitesell, Baohui Zhao, Shufen Cai, William T. McMillen, Shripad V. Bhagwat
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d0dc26b8998855020bf945222d1189
https://doi.org/10.1158/1535-7163.22507273.v1
https://doi.org/10.1158/1535-7163.22507273.v1
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
LY3295668 chemical characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459c3119cab021ba3189b2c2e7d96d2e
https://doi.org/10.1158/2159-8290.22533034.v1
https://doi.org/10.1158/2159-8290.22533034.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ab9e588f7270d239b69faebcc24e90
https://doi.org/10.1158/1535-7163.22506969.v1
https://doi.org/10.1158/1535-7163.22506969.v1
Autor:
Sheng-Bin Peng, Sajan Joseph, Ramon V. Tiu, Gregory D. Plowman, Michael J. Rodriguez, Eunice Yuen, Jennie Walgren, Jason Manro, Andrew J. Dropsey, Denis McCann, Xi Rao, Robert D. Van Horn, Meghann Pogue, Xiu-Juan Yuan, Yan Zhai, Bryan Anderson, Wenjuan Wu, Robert S. Flack, Lisa Kindler, Weihua Shen, Matthew Whitesell, Baohui Zhao, Shufen Cai, William T. McMillen, Shripad V. Bhagwat
In vivo effect of treatment on body weight loss.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952c561d8520c3c104049374b206e09a
https://doi.org/10.1158/1535-7163.22507276.v1
https://doi.org/10.1158/1535-7163.22507276.v1