Zobrazeno 1 - 10
of 64
pro vyhledávání: '"D. Plocová"'
Autor:
Tomas Olejar, D Plocová, M Zadinová, Jiří Strohalm, Jaroslav Matoušek, M Zitko, Karel Ulbrich, Josef Soucek, Hlousková D, M Špunda, Pavla Pouckova
Publikováno v:
Journal of Controlled Release. 95:83-92
The hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) was used for RNase A or BS-RNase modification to prevent their degradation in bloodstream or fast elimination. Two PHPMA chains (classic and star-like) were synthesized and their conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafb437a2f4d8b6055336dae4b00b02a
https://doi.org/10.1016/j.jconrel.2003.11.008
https://doi.org/10.1016/j.jconrel.2003.11.008
Autor:
M. Št'astný, Jiří Strohalm, L Dráberová, D Plocová, Blanka Rihova, Karel Ulbrich, O. Hovorka, Marek Kovar, Markéta Jelínková
Publikováno v:
Bioconjugate Chemistry. 11:664-673
The aim of this study was to compare the potential of two plant lectins [peanut agglutinin (PNA) and wheat germ agglutinin (WGA)], monoclonal antibody (anti-Thy-1.2), its F(ab')(2) fragments, and galactosamine as targeting moieties bound to the polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c218bde15d0214cb28fb333378d3cb
https://doi.org/10.1021/bc9901696
https://doi.org/10.1021/bc9901696
Autor:
Karel Ulbrich, Blanka Říhová, D Plundrová, Y Germano, Markéta Jelínková, M Novák, D Plocová, O. Hovorka, Jiří Strohalm, Vladimir Subr
Publikováno v:
Journal of Controlled Release. 64:241-261
We provide data on in vivo targeting of the Thy 1.2 (CDw90) cell surface receptor expressed on neoplastic T cells, mouse EL4 T cell lymphoma. The targeting antibody and the anticancer drug, doxorubicin (DOX) were conjugated to a water-soluble copolym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e31789bc84f302fe495b6d2fe624986
https://doi.org/10.1016/s0168-3659(99)00140-6
https://doi.org/10.1016/s0168-3659(99)00140-6
Publikováno v:
Journal of Controlled Release. 64:63-79
This paper describes the synthesis, physico-chemical characteristics and results of selected biological tests of conjugates of antibodies or proteins with poly(HPMA) or with poly(HPMA) carriers of anti-cancer drug doxorubicin, designed for targeted c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58221c6773a87873112cd20515afd702
https://doi.org/10.1016/s0168-3659(99)00141-8
https://doi.org/10.1016/s0168-3659(99)00141-8
Autor:
D Plocová, David Oupický, Vladimir Subr, Karel Ulbrich, Pavla Pouckova, Josef Matoušek, Jiri Strohalm, Josef Soucek
Publikováno v:
Journal of Bioactive and Compatible Polymers. 15:4-26
The synthesis of three conjugates of poly(HPMA) with bovine seminal ribonuclease (BS-RNase) differing in their structure is described. Two conjugates contained BS-RNase conjugated with the polymer via functional group situated at the end of the polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aadd5e68c27c5a6158869d758969713
https://doi.org/10.1106/3frb-dc5h-vaad-arpx
https://doi.org/10.1106/3frb-dc5h-vaad-arpx
Autor:
J. Šrogl, D Plocová, Markéta Jelínková, Blanka Říhová, Karel Ulbrich, Vladimir Subr, Milada Šírová, Jiří Strohalm
Publikováno v:
Journal of Controlled Release. 40:303-319
Recently we have developed a new generation of antibody-targeted immunosuppressive (cyclosporin A, CyA) and cytostatic (doxorubicin, Dox) drugs effective in vitro and in vivo. The drugs and the targeting antibody (polyclonal and monoclonal anti-Thy 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7277236830b03542b37b9357a6a48ef0
https://doi.org/10.1016/0168-3659(95)00198-0
https://doi.org/10.1016/0168-3659(95)00198-0
Autor:
D Plocová, O. Hovorka, Blanka Rihova, Karel Ulbrich, Jan Bouček, T Etrych, Petr Chytil, V. Šubr, Robert Pola, Jiří Strohalm
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 127(2)
A systematic study was designed to elucidate differences in cytostatic activity in vitro between HPMA-based doxorubicin conjugates synthesized using different polymerization techniques and differing in peptidyl side chain. A polymer-drug conjugate co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec4c2343fa417883dfe1b46f0b87283
https://pubmed.ncbi.nlm.nih.gov/18325618
https://pubmed.ncbi.nlm.nih.gov/18325618
Autor:
B. Říhová, J. Strohalm, J. Prausová, K. Kubáčková, M. Jelínková, L. Rozprimová, M. Šírová, D. Plocová, T. Etrych, V. Šubr, T. Mrkvan, M. Kovář, K. Ulbrich
Publikováno v:
Advanced Biomaterials for Medical Applications ISBN: 9781402029073
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de620832bcb24c591beb01cf35b76b57
https://doi.org/10.1007/978-1-4020-2908-0_6
https://doi.org/10.1007/978-1-4020-2908-0_6
Publikováno v:
Journal of drug targeting. 10(3)
Recently hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) was used for BS-RNase modification to prevent its degradation in bloodstream or fast elimination. Polymer-conjugated BS-RNase preparations proved to be cytotoxic after intravenous o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6603d36a5c39d702b268dacc4a88f3f
https://pubmed.ncbi.nlm.nih.gov/12075818
https://pubmed.ncbi.nlm.nih.gov/12075818
Publikováno v:
European journal of cancer (Oxford, England : 1990). 38(4)
Treatment of an established BCL1 leukaemia in mice showed that the use of hydrogels is advantageous in comparison with free doxorubicin (DOX), partially due to the different pharmacokinetic profile of the drug release. Pharmacologically active concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f550cc29eb5855d1c159f65e4a381b
https://pubmed.ncbi.nlm.nih.gov/11872356
https://pubmed.ncbi.nlm.nih.gov/11872356