Zobrazeno 1 - 10
of 670
pro vyhledávání: '"D. Plant"'
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Around 10% of school-aged children experience mental health difficulties. Many more are ‘vulnerable’: experiencing emotional and/or behavioural problems reaching clinical levels, and thus at greatest risk of future mental illn
Externí odkaz:
https://doaj.org/article/d7d7ba4cc22441628926755f27b63c2a
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Post-translational SUMOylation of nuclear and cytosolic proteins maintains homeostasis in eukaryotic cells and orchestrates programmed responses to changes in metabolic demand or extracellular stimuli. In excitable cells, SUMOylation tunes t
Externí odkaz:
https://doaj.org/article/763cc5b154034463b7c993f525964c41
Autor:
Yu Xu, Yuchen Yang, Aishwarya Chandrashekar, Kirin D. Gada, Meghan Masotti, Austin M. Baggetta, Jenna G. Connolly, Takeharu Kawano, Leigh D. Plant
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104969- (2022)
Summary: Cardiovascular diseases remain the leading cause of death worldwide. Most deaths are sudden and occur secondary to the occlusion of coronary arteries resulting in a rapid decrease in cellular oxygen levels. Acute hypoxia is proarrhythmic, le
Externí odkaz:
https://doaj.org/article/ea4610ea29784b029883e64fd4901ee5
Autor:
Robert D. Plant, M. Ziad Saghir
Publikováno v:
International Journal of Thermofluids, Vol 9, Iss , Pp 100055- (2021)
Nanofluids are often able to provide a method to increase the possible heat transfer of a system, with relatively few detrimental factors created by its inclusion. The use of nanofluids and their optimal concentrations has become an area of great int
Externí odkaz:
https://doaj.org/article/76bac363ce3842b095d0e3141e09cd6e
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2225-2236.e4 (2020)
Summary: Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive,
Externí odkaz:
https://doaj.org/article/153af7352f2d4e398ac2f2b643dd0b3a
Autor:
Xiuxiu Wang, Nan Yang, Juan Su, Chenchen Wu, Shengtang Liu, Lei Chang, Leigh D. Plant, Xuanyu Meng
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 123 (2022)
The endohedral metallofullerenol Gd@C82(OH)22 has been identified as a possible antineoplastic agent that can inhibit both the growth and metastasis of cancer cells. Despite these potentially important effects, our understanding of the interactions b
Externí odkaz:
https://doaj.org/article/0654fb554e5d492bb58f244a3ed7c6ef
Autor:
Thierry Olivry, Emmanuel Bensignor, Claude Favrot, Craig E. Griffin, Peter B. Hill, Ralf S. Mueller, Jon D. Plant, Hywel C. Williams, for the International Committee of Allergic Diseases of Animals (ICADA)
Publikováno v:
BMC Veterinary Research, Vol 14, Iss 1, Pp 1-8 (2018)
Abstract Background For decades, the efficacy of interventions in clinical trials enrolling dogs with atopic dermatitis (AD) relied on heterogeneous evaluations of skin lesions and pruritus using unvalidated tools. Although some instruments for clini
Externí odkaz:
https://doaj.org/article/c317fbf3a6a241329c785e5c307bc2cf
Autor:
Francisco Sepúlveda, Leigh D. Plant, Daniel L. Minor, Jr., Florian Lesage, Steve A.N. Goldstein, Péter Enyedi, Gábor Czirják, Douglas A. Bayliss, Austin M. Baggetta
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators. The pore-f
Autor:
Kirin D. Gada, Jordie M. Kamuene, Aishwarya Chandrashekar, R. Charles Kissell, Anne K. Yauch, Leigh D. Plant
Publikováno v:
Journal of General Physiology. 155
Voltage-gated sodium (NaV) channels are densely expressed in most excitable cells and activate in response to depolarization, causing a rapid influx of Na+ ions that initiates the action potential. The voltage-dependent activation of NaV channels is
Autor:
Oron Kotler, Yana Khrapunsky, Arik Shvartsman, Hui Dai, Leigh D Plant, Steven AN Goldstein, Ilya Fleidervish
Publikováno v:
eLife. 12
Voltage-gated sodium channels located in axon initial segments (AIS) trigger action potentials (AP) and play pivotal roles in the excitability of cortical pyramidal neurons. The differential electrophysiological properties and distributions of NaV1.2