Výsledky vyhledávání

Differences in hepatic drug accumulation and enzyme induction after chronic amiodarone feeding of two rat strains: role of the hydroxylator phenotype?

Autor: M. Pirovino, Th. Zysset, M. Tinel, O. Müller, D. Pessayre, Ulrich E. Honegger, A. Küpfer

Publikováno v: British Journal of Pharmacology. 99:35-40

1. It has previously been shown that the extent of hepatic phospholipidosis induced by chronic amiodarone treatment correlates with the degree of drug accumulation in liver tissue. 2. To investigate a possible influence of pharmacogenetic factors, bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd6ca35407818b63cc1ada543ffa79f
https://doi.org/10.1111/j.1476-5381.1990.tb14650.x

Zobrazit plný text záznamu

Drug induced Hepatotoxicity and Mitochondrial Dysfunction

Autor: B. Fromenty, C. Maisonneuve, R. Note, A. Berson, D. Pessayre

Publikováno v: Mitochondrial Disorders ISBN: 9782817809311

Mitochondria are involved in fatty acid β-oxidation, the tricarboxylic acid cycle and oxidative phosphorylation, which provide most of the cell energy. Mitochondria are also the main source of reactive oxygen species in the cell and are involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fdd33b54a3aace5dd9447988cc9ebde
https://doi.org/10.1007/978-2-8178-0929-8_8

Zobrazit plný text záznamu

Hepatotoxicity due to mitochondrial dysfunction

Autor: D, Pessayre, A, Mansouri, D, Haouzi, B, Fromenty

Publikováno v: Cell biology and toxicology. 15(6)

Mitochondria are involved in fatty acid beta-oxidation, the tricarboxylic acid cycle, and oxidative phosphorylation, which provide most of the cell energy. Mitochondria are also the main source of reactive oxygen species in the cell and are involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdb2e1495d207a8ac1ba1b8e93ceea48
https://pubmed.ncbi.nlm.nih.gov/10811531

Zobrazit plný text záznamu

Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes

Autor: M, Lekehal, D, Pessayre, J M, Lereau, C, Moulis, I, Fouraste, D, Fau

Publikováno v: Hepatology (Baltimore, Md.). 24(1)

Several herbal remedies have produced hepatitis in humans. The medicinal plant, germander, was recalled after its use as an adjuvant to slimming diets resulted in an epidemic of hepatitis in France. We studied the hepatotoxicity of germander in isola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e699c6dcfa1e57ddcf32446e28a1cd7f
https://pubmed.ncbi.nlm.nih.gov/8707265

Zobrazit plný text záznamu

Deleterious influence of pyrazinamide on the outcome of patients with fulminant or subfulminant liver failure during antituberculous treatment including isoniazid

Autor: F, Durand, J, Bernuau, D, Pessayre, D, Samuel, J, Belaiche, C, Degott, H, Bismuth, J, Belghiti, S, Erlinger, B, Rueff

Publikováno v: Hepatology (Baltimore, Md.). 21(4)

Isoniazid and pyrazinamide are well-known hepatotoxic drugs, often used in combination. The aim of this study was to assess the prognostic influence of pyrazinamide on the outcome of fulminant or subfulminant liver failure caused by antituberculous t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d24839674abc48e1b7d4d25dfc4481a
https://pubmed.ncbi.nlm.nih.gov/7705802

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání