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Akademický článek

Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy

Autor: Weijun Ou, Joshua Yang, Juste Simanauskaite, Matthew Choi, Demi M. Castellanos, Rudy Chang, Jiahong Sun, Nataraj Jagadeesan, Karen D. Parfitt, David H. Cribbs, Rachita K. Sumbria

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)

Abstract Background Tumor necrosis factor-α (TNF-α) plays a central role in Alzheimer’s disease (AD) pathology, making biologic TNF-α inhibitors (TNFIs), including etanercept, viable therapeutics for AD. The protective effects of biologic TNFIs

Externí odkaz: https://doaj.org/article/6e93ff10e37147479a9c27eeeef00f70

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Akademický článek

A high-entropy manganite in an ordered nanocomposite for long-term application in solid oxide cells

Autor: F. Baiutti, F. Chiabrera, M. Acosta, D. Diercks, D. Parfitt, J. Santiso, X. Wang, A. Cavallaro, A. Morata, H. Wang, A. Chroneos, J. MacManus-Driscoll, A. Tarancon

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Electrode functional layers for solid oxide cells require a combination of high reactivity and thermal stability. Here, the authors present a self-assembled vertically aligned nanocomposites of lanthanum strontium manganite and doped ceria as functio

Externí odkaz: https://doaj.org/article/51d7a6e1438c486b89403ec64b81b333

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Akademický článek

UC pistachio cultivars show improved nut quality and are ready for harvest earlier than ‘Kerman’

Autor: C Kallsen, D Parfitt, J Maranto

Publikováno v: California Agriculture, Vol 74, Iss 2 (2020)

California pistachio growers have traditionally grown only one female cultivar (‘Kerman’) and one male pollenizer (‘Peters’). Starting in 2005, the UC breeding program released several improved cultivars, which are being planted on increasing

Externí odkaz: https://doaj.org/article/272cbd2e760143018f666c54ae7c6a49

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Akademický článek

Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease

Autor: Valerie T. Y. Tan, Bruce G. Mockett, Shane M. Ohline, Karen D. Parfitt, Hollie E. Wicky, Katie Peppercorn, Lucia Schoderboeck, Mohamad Fairuz bin Yahaya, Warren P. Tate, Stephanie M. Hughes, Wickliffe C. Abraham

Publikováno v: Molecular Brain, Vol 11, Iss 1, Pp 1-16 (2018)

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease driven in large part by accumulated deposits in the brain of the amyloid precursor protein (APP) cleavage product amyloid-β peptide (Aβ). However, AD is also characterised by reduct

Externí odkaz: https://doaj.org/article/829842a4c1ec4ba690c8af863cc84017

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Akademický článek

The Tripeptide RER Mimics Secreted Amyloid Precursor Protein-Alpha in Upregulating LTP

Autor: Jodi A. Morrissey, Erin Bigus, Julie C. Necarsulmer, Vinay Srinivasan, Katie Peppercorn, Daniel J. O’Leary, Bruce G. Mockett, Warren P. Tate, Stephanie M. Hughes, Karen D. Parfitt, Wickliffe C. Abraham

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

Secreted amyloid precursor protein-alpha (sAPPα), generated by enzymatic processing of the APP, possesses a range of neurotrophic and neuroprotective properties and plays a critical role in the molecular mechanisms of memory and learning. One of the

Externí odkaz: https://doaj.org/article/17c333daa54044fa944310ae25f4bb81

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