Zobrazeno 1 - 10
of 26
pro vyhledávání: '"D. P. Fairlie"'
Autor:
J Y, Suen, M N, Adams, J, Lim, P K, Madala, W, Xu, A J, Cotterell, Y, He, M K, Yau, J D, Hooper, D P, Fairlie
Publikováno v:
Pharmacological research. 117
Proteinase-activated receptor 2 (PAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb379d4637207dfeabce0c993c97bd8e
https://pubmed.ncbi.nlm.nih.gov/27993717
https://pubmed.ncbi.nlm.nih.gov/27993717
Publikováno v:
Letters in Peptide Science. 7:347-351
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa6593459a442fa12ef626a8d9f2820
https://doi.org/10.1007/bf02443598
https://doi.org/10.1007/bf02443598
Publikováno v:
British journal of pharmacology. 171(5)
Although it has been known since the 1960s that trypsin and chymotrypsin can mimic hormone action in tissues, it took until the 1990s to discover that serine proteinases can regulate cells by cleaving and activating a unique four-member family of GPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf2f1047bbd33f111e2f7e85f2478aac
https://pubmed.ncbi.nlm.nih.gov/24354792
https://pubmed.ncbi.nlm.nih.gov/24354792
Publikováno v:
British journal of pharmacology. 165(5)
Many cells express proteinase activated receptor 2 (PAR2) on their plasma membrane. PAR2 is activated by proteolytic enzymes, such as trypsin and tryptase that cleave the receptor N-terminus, inititating signalling to intracellular G proteins. Studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4c1baeba6e84b73a0d8514950d6094c
https://pubmed.ncbi.nlm.nih.gov/21806599
https://pubmed.ncbi.nlm.nih.gov/21806599
Publikováno v:
Journal of periodontal research. 46(6)
Bone loss caused by enhanced osteoclast activity is a significant feature of periodontitis. Histone deacetylase inhibitors (HDACi) can suppress osteoclast-mediated bone loss in vitro and in vivo. This study investigated whether HDACi can suppress bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01dc09bbaf31d28405231153b6dbc697
https://pubmed.ncbi.nlm.nih.gov/21745207
https://pubmed.ncbi.nlm.nih.gov/21745207
Autor:
R P, McGeary, D P, Fairlie
Publikováno v:
Current opinion in drug discoverydevelopment. 1(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f07a3edbd2ba0f957d4c1346a5741c48
https://pubmed.ncbi.nlm.nih.gov/19649821
https://pubmed.ncbi.nlm.nih.gov/19649821
Autor:
W. G. Jackson, D. P. Fairlie
Publikováno v:
Inorganic Chemistry. 29:3139-3145
Coordination of ethyl carbamate via N rather than O to the pentaamminecobalt(III) moiety results in activation toward ligand hydrolysis. The carbonyl oxygen of the carbamate anion and of its ethyl ester (urethane) are preferentially coordinated in ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a520b2a65c9a697dbb2e1cd7396ec3f3
https://doi.org/10.1021/ic00342a017
https://doi.org/10.1021/ic00342a017
Publikováno v:
British journal of pharmacology. 152(4)
Complement fragment (C)5a is a 74 residue pro-inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury. C5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f45b08e8aafe86090fdd3d13b375a99
https://pubmed.ncbi.nlm.nih.gov/17603557
https://pubmed.ncbi.nlm.nih.gov/17603557
Publikováno v:
IDrugs : the investigational drugs journal. 2(7)
During host defense, the human complement system of plasma proteins initiates inflammatory and cellular immune responses to stimuli such as infectious organisms, chemical and physical injury, radiation and neoplasia. Elevated levels of one of these p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a783de360fb33617a1886c40a5ba6614
https://pubmed.ncbi.nlm.nih.gov/16127639
https://pubmed.ncbi.nlm.nih.gov/16127639
Autor:
T M, Woodruff, A J, Strachan, S D, Sanderson, P N, Monk, A K, Wong, D P, Fairlie, S M, Taylor
Publikováno v:
Inflammation. 25(3)
This study investigated the receptor binding affinities of a C5a agonist and cyclic antagonists for polymorphonuclear leukocytes (PMNs) isolated from human, sheep, pig, dog, rabbit, guinea pig, rat and mouse. The affinities of the two small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e7b14ddaa94295d7953afc61ef20a0f
https://pubmed.ncbi.nlm.nih.gov/11403208
https://pubmed.ncbi.nlm.nih.gov/11403208