Zobrazeno 1 - 10
of 10
pro vyhledávání: '"D. P. Clarkson"'
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-23 (2022)
Abstract The causes of grey matter pathology and diffuse neuron injury in MS remain incompletely understood. Axonal stress signals arising from white matter lesions has been suggested to play a role in initiating this diffuse grey matter pathology. T
Externí odkaz:
https://doaj.org/article/a46d531f7ce247d99dcf9b3fff91ab9a
Autor:
Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings implicate senescent cell clearance as a strategy to counter aged brain inflammation and cognitive decline.
Externí odkaz:
https://doaj.org/article/563782268a174f9491ef229d9fd5e5e9
Autor:
Parijat Kabiraj, Ethan M. Grund, Benjamin D. S. Clarkson, Renee K. Johnson, Reghann G. LaFrance-Corey, Claudia F. Lucchinetti, Charles L. Howe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Astrocytes utilize both glycolytic and mitochondrial pathways to power cellular processes that are vital to maintaining normal CNS functions. These cells also mount inflammatory and acute phase reactive programs in response to diverse stimul
Externí odkaz:
https://doaj.org/article/6082d9204e764fd28bf335baa7845997
Autor:
Charles L. Howe, Reghann G. LaFrance-Corey, Brittany L. Overlee, Renee K. Johnson, Benjamin D. S. Clarkson, Emma N. Goddery
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background The pathogenic contribution of neuroinflammation to ictogenesis and epilepsy may provide a therapeutic target for reduction of seizure burden in patients that are currently underserved by traditional anti-seizure medications. The
Externí odkaz:
https://doaj.org/article/36d646d746d34492ad1f55df48b32c7d
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract During acute neuroinflammation, increased levels of cytokines within the brain may contribute to synaptic reorganization that results in long-term changes in network hyperexcitability. Indeed, inflammatory cytokines are implicated in synapti
Externí odkaz:
https://doaj.org/article/0e0ef023671b49c3bc9fbae98d663724
Publikováno v:
Biochemical Journal. 125:439-447
1. Hepatic glucose 6-phosphate dehydrogenase activity was increased in rats exposed to 5lb/in(2) (equivalent to 27000ft), 100% O(2) when compared with control animals in a 14.7lb/in(2) (sea level), air environment. Glyceraldehyde 3-phosphate dehydrog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1c7096676adc4f73a151074422a76d
https://doi.org/10.1042/bj1250439
https://doi.org/10.1042/bj1250439
Publikováno v:
American Journal of Physiology-Legacy Content. 222:1494-1498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204ae4eadc89ca238f0771ff02f4db67
https://doi.org/10.1152/ajplegacy.1972.222.6.1494
https://doi.org/10.1152/ajplegacy.1972.222.6.1494
Publikováno v:
Space Life Sciences. 4:424-433
Measurement of metabolic adaptation to marginally stressful environments requires both precise regulation of a variety of atmospheric factors for extended periods of time and the capacity to employ sensitive parameters in an undisturbed subject. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef544a0b78bcab09c08f2e34f058a09
https://doi.org/10.1007/bf00930354
https://doi.org/10.1007/bf00930354
Autor:
J. H. Ferguson, D. P. Clarkson
Publikováno v:
International Journal of Biometeorology. 16:269-276
The effect of ambient temperature on the daily running activity of the red squirrel TAMIASCIURUS HUDSONICUS was investigated. Running-wheel activity (min/day) of live-trapped male and female animals was monitored for 7 days in the laboratory after 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5d4348580dd8404e25724e420c43f2
https://doi.org/10.1007/bf01553738
https://doi.org/10.1007/bf01553738
Publikováno v:
The American journal of physiology. 225(3)
Experiments were performed to describe qualitatively and quantitatively the nonthermal metabolic response of rats to normoxic mixtures of helium, nitrogen, or argon at 1 atm ambient pressure. Hypoxic mixtures were similarly tested to determine any di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2426b60a098134722949638f3b0d9cc
https://pubmed.ncbi.nlm.nih.gov/4726489
https://pubmed.ncbi.nlm.nih.gov/4726489