Výsledky vyhledávání - "D. Oosterhoff"

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

Publikováno v: OncoImmunology
Oncoimmunology, 8, e1631119
OncoImmunology, Vol 8, Iss 10 (2019)
Oncoimmunology, 8, 10, pp. e1631119
Oncoimmunology
Gonzalez, M L, Oosterhoff, D, Lindenberg, J J, Milenova, I, Lougheed, S M, Martianez, T, Dekker, H, Quixabeira, D C A, Hangalapura, B, Joore, J, Piersma, S R, Cervera-Carrascon, V, Santos, J M, Scheper, R J, Verheul, H M W, Jimenez, C R, Van De Ven, R, Hemminki, A, Van Beusechem, V W & De Gruijl, T D 2019, ' Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression ', OncoImmunology, vol. 8, no. 10 . https://doi.org/10.1080/2162402X.2019.1631119
OncoImmunology, 8(10). Landes Bioscience

Contains fulltext : 215594.pdf (Publisher’s version ) (Open Access) In patients with cancer, the functionality of Dendritic Cells (DC) is hampered by high levels of tumor-derived suppressive cytokines, which interfere with DC development and matura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5884228836047b9b052b68ffccf0f98
http://www.scopus.com/inward/record.url?scp=85071069506&partnerID=8YFLogxK

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Irritant-Induced Migration of Langerhans Cells Coincides with an IL-10-Dependent Switch to a Macrophage-Like Phenotype

Autor: Tanja D. de Gruijl, Krista Ouwehand, Rik J. Scheper, Susan Gibbs, D. Oosterhoff, Melanie Breetveld

Publikováno v: Journal of Investigative Dermatology, 131, 418-425. Nature Publishing Group
Ouwehand, K, Oosterhoff, D, Breetveld, M, Scheper, R J, de Gruijl, T D & Gibbs, S 2011, ' Irritant-induced migration of Langerhans cells coincides with an IL-10-dependent switch to a macrophage-like phenotype. ', Journal of Investigative Dermatology, vol. 131, pp. 418-425 . https://doi.org/10.1038/jid.2010.336

Langerhans cells (LCs) migrate after topical exposure of the skin to irritants, despite the supposed independence of irritant contact dermatitis from adaptive immunity. Whereas allergen-activated LCs are known to migrate to the draining lymph nodes (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e932e010555337d621890109aa0c4a60
https://doi.org/10.1038/jid.2010.336

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Akademický článek

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The dermis as a portal for dendritic cell-targeted immunotherapy of cutaneous melanoma

Autor: D, Oosterhoff, B J R, Sluijter, B N, Hangalapura, T D, de Gruijl

Publikováno v: Current topics in microbiology and immunology. 351

Complete surgical excision at an early stage remains the only curative treatment for cutaneous melanoma with few available adjuvant therapy options. Nevertheless, melanoma is a relatively immunogenic tumor type and particularly amenable to immunother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e590d72df7879f31c003376f15990e3d
https://pubmed.ncbi.nlm.nih.gov/21681685

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Potent antitumor immunity generated by a CD40-targeted adenoviral vaccine

Autor: Louis Boon, D. Oosterhoff, Basav N. Hangalapura, Thomas Tüting, R.J. Scheper, Alexander Pereboev, Victor W. van Beusechem, W R Gerritsen, David T. Curiel, T.D. de Gruijl, J. de Groot, A.J.M. van den Eertwegh

Publikováno v: Hangalapura, B N, Oosterhoff, D, de Groot, J, Boon, L, Tuting, T, van den Eertwegh, A J M, Gerritsen, W R, van Beusechem, V W, Pereboev, A, Curiel, D T, Scheper, R J & de Gruijl, T D 2011, ' Potent anti-tumor immunity generated by a CD40-targeted adenoviral vaccine. ', Cancer Research, vol. 71, no. 17, pp. 5827-5837 . https://doi.org/10.1158/0008-5472.CAN-11-0804
Cancer Research, 71, 17, pp. 5827-37
Cancer Research, 71, 5827-37
Cancer Research, 71(17), 5827-5837. American Association for Cancer Research Inc.

In situ delivery of tumor-associated antigen (TAA) genes into dendritic cells (DC) has great potential as a generally applicable tumor vaccination approach. Although adenoviruses (Ad) are an attractive vaccine vehicle in this regard, Ad-mediated tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9119337b4cf4889691e0d3b5b1c4ffb
https://doi.org/10.1158/0008-5472.CAN-11-0804

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Akademický článek

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Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein

Autor: Michelle de Graaf, Epie Boven, Ida H van der Meulen-Muileman, D. Oosterhoff, Hidde J. Haisma, Winald R. Gerritsen, Herbert M. Pinedo

Publikováno v: Human gene therapy. 15(3)

Tumor-specific activation of the glucuronide prodrug of doxorubicin, N-[4-doxorubicin-N-carbonyl( oxymethyl) phenyl]-O-beta-glucuronyl carbamate (DOX-GA3), by beta-glucuronidase present in necrotic tumor areas might be improved after transduction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f473e9e7445dbca75df7476198df6d98
https://pubmed.ncbi.nlm.nih.gov/15018732

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Secreted and tumour targeted human carboxylesterase for activation of irinotecan

Autor: T Sone, Frank A.E. Kruyt, W R Gerritsen, M de Graaf, H.M. Pinedo, Victor W. van Beusechem, I H van der Meulen, Hidde J. Haisma, D. Oosterhoff

Publikováno v: British Jounal of Cancer, 87(6), 659-664. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer, 87(6), 659-64. Nature Publishing Group
Oosterhoff, D, Pinedo, H M, van der Meulen, I H, de Graaf, M, Sone, T, Kruyt, F A, van Beusechem, V W, Haisma, H J & Gerritsen, W R 2002, ' Secreted and tumour targeted human carboxylesterase for activation of irinotecan ', British Journal of Cancer, vol. 87, no. 6, pp. 659-64 . https://doi.org/10.1038/sj.bjc.6600519

Irinotecan (CPT-11) is an anticancer agent for the treatment of colon cancer. CPT-11 can be considered as a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme carboxylesterase. An approach to achieve tumour specific activ

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https://research.rug.nl/en/publications/83ad42e0-24ae-4919-9f02-07572765211e

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