The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer

Autor: Wendy A Cooper, Andrew Burgess, Vinod Ganju, Craig D. Peacock, Rachael A. McCloy, Anette Szczepny, W S N Jayasekara, Julien Sage, Kwon-Sik Park, D N Watkins, Samuel Rogers, Jason E. Cain, C R Cochrane

Publikováno v: Oncogene

Hedgehog (Hh) signaling regulates cell fate and self-renewal in development and cancer. Canonical Hh signaling is mediated by Hh ligand binding to the receptor Patched (Ptch), which in turn activates Gli-mediated transcription through Smoothened (Smo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f393a5ee382f4c44fe2df68836264e04
https://doi.org/10.1038/onc.2017.173

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Autor: A Dickinson, Andrew R. Cuddihy, Jason E. Cain, William Lee, Andrew Spencer, Jacqueline Johnson, J. C. St. John, Beena Kumar, Terrance Grant Johns, D N Watkins, K-Y Yeung

Publikováno v: Cell Death Discovery

Although mitochondrial DNA has been implicated in diseases such as cancer, its role remains to be defined. Using three models of tumorigenesis, namely glioblastoma multiforme, multiple myeloma and osteosarcoma, we show that mitochondrial DNA plays de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f02478de2c9940600d6559317db3b42
https://doi.org/10.1038/cddiscovery.2016.16

ATYPICAL TERATOID RHABDOID TUMOUR

Autor: A. I. Bertozzi, C. Munzer, F. Fouyssac, N. Andre, S. Boetto, P. Leblond, F. Bourdeaut, C. Dufour, R. K. Deshpande, K. G. Bhat, S. Mahalingam, A. Muscat, J. Cain, M. Ferguson, D. Popovski, E. Algar, F. J. Rossello, S. Jayasekara, D. N. Watkins, J. Hodge, D. Ashley, M. Hishii, M. Saito, H. Arai, Z. Y. Han, W. Richer, C. Lucchesi, P. Freneaux, A. Nicolas, C. Grison, G. Pierron, O. Delattre, S. Epari, N. TS, T. Gupta, G. Chinnaswamy, J. G. Sastri, P. Shetty, A. Moiyadi, R. Jalali, T. Fay-McClymont, D. Johnston, L. Janzen, S. Guger, K. Scheinemann, A. Fleming, C. Fryer, J. Hukin, D. Mabbott, A. Huang, E. Bouffet, L. Lafay-Cousin, A. Kawamura, K. Yamamoto, T. Nagashima, K. Bartelheim, M. Benesch, J. Buchner, J. Gerss, M. Hasselblatt, R.-D. Kortmann, G. Fleischack, E. Quiroga, H. Reinhard, R. Schneppenheim, A. Seeringer, R. Siebert, B. Timmermann, M. Warmuth-Metz, I. Schmid, M. C. Fruhwald, K. Kerl, T. Klingebiel, A. Al-Kofide, Y. Khafaga, H. Al-Hindi, M. Dababo, A. Ul-Haq, M. Anas, M. G. Barria, K. Siddiqui, M. Hassounah, M. Ayas, E. Al-Shail, A. Jeibmann, K. Eikmeier, A. Linge, P. Johann, B. Koos, M. Kool, S. M. Pfister, W. Paulus, U. Schuller, R. Junckerstorff, M. K. Rosenblum, A. H. Alassiri, S. Rossi, N. Gottardo, H. Toledano, E. Viscardi, L. Witkowski, I. Nagel, F. Oyen, W. D. Foulkes, D. Schrey, G. Malietzis, S. Chi, L. Marshall, F. Carceller, L. Moreno, S. Zacharoulis, R. Bhardwaj, M. Chakravadhanula, V. Ozals, C. Hampton, R. Metpally, P. Grillner, J. Asmundsson, B. Gustavsson, S. Holm, P. D. Johann, A. Korshunov, M. Ryzhova, T. Milde, O. Witt, D. T. W. Jones, V. Hovestadt, A. Gajjar, M. Fruhwald, S. Pfister, M. Finetti, A. d. C. Pons, M. Selby, A. Smith, S. Crosier, J. Wood, B. Skalkoyannis, S. Bailey, S. Clifford, D. Williamson, S. Rutkowski, R. D. Kortmann, N. Graf, J. Boos, K. Nysom, N. Moreno, T. Holsten, J. Ahlfeld, J. Mertins, M. Hotfilder, S. Schleicher, R. Handgretinger, M. Meisterernst, C. Schmidt, S. Dittmar, G. C. F. Chan, M. M. K. Shing, H. L. Yuen, R. C. H. Li, S. L. Ling, I. Slavc, A. Peyrl, M. Chocholous, A. Azizi, T. Czech, K. Dieckmann, C. Haberler, U. Leiss, G. Gotti, V. Biassoni, E. Schiavello, F. Spreafico, E. Pecori, L. Gandola, M. Massimino, K. Kornelius, H. Yano, N. Nakayama, N. Ohe, M. Ozeki, K. Kanda, T. Kimura, T. Hori, T. Fukao, T. Iwama, A. G. Weil, A. Diaz, J. Gernsback, S. Bhatia, J. Ragheb, T. Niazi, Z. Khatib, A. Zoghbi, a. M. Meisterernst, D. Birks, A. Griesinger, V. Amani, A. Donson, R. Posner, C. Dunham, B. K. Kleinschmidt-DeMasters, M. Handler, R. Vibhakar, N. Foreman, L. Zhou, D. Catchpoole, A. Kakkar, A. Biswas, V. Suri, M. Sharma, S. Kale, A. Mahapatra, C. Sarkar, J. Torchia, D. Picard, K. C. Ho, D.-A. Khuong-Quang, L. Louterneau, M. Bourgey, T. Chan, B. Golbourn, L.-L. Cousin, M. D. Taylor, P. Dirks, J. T. Rutka, C. Hawkins, J. Majewski, S.-K. Kim, N. Jabado, J. H.-C. Chang, M. Confer, A. Chang, S. Goldman, M. Dunn, W. Hartsell

Atypical teratoid rhabdoid tumor of the brain is a rare embryonal tumor of infancy which has become more widely recognized due to specific immunostaining now more routinely available. These tumors still carry a poor prognosis and no standard therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54d5e07bab3803933652aef435ff427
https://europepmc.org/articles/PMC4046281/

Quality In Lung Cancer Care: The Development Of A Population Based Lung Cancer Registry

Autor: D N. Watkins, Susan E. Evans, Peta Mclaughlin, Robert G Stirling, Meera Senthuren, John McNeil

Publikováno v: C102. QUALITY IMPROVEMENT IN PULMONARY MEDICINE.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b960d472ffe61ca4cee657b8c356ebaf
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5142

Oxidant stress induces gamma-glutamylcysteine synthetase and glutathione synthesis in human bronchial epithelial NCI-H292 cells

Autor: S, Ray, D N, Watkins, N L A, Misso, P J, Thompson

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 32(4)

The bronchial epithelium is exposed to reactive oxygen species (ROS) derived from cigarette smoke, air pollutants and activated leucocytes. Glutathione (GSH) prevents ROS-mediated loss of cell function, tissue injury and inflammation, and its synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0db91651cdef385ce2a7dedbb8b0bda
https://pubmed.ncbi.nlm.nih.gov/11972591