Výsledky vyhledávání - "D. N. Scampoli"

Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis

Autor: Ronald P. Gladue, Henry J. Showell, D. N. Scampoli, E. D. Salter, E. R. Pettipher, L A Carroll, L Contillo, A J Milici, Hans Stukenbrok

Publikováno v: The Journal of Experimental Medicine

Leukotriene B4 (LTB4) is a chemotactic and cell-activating factor present at inflammatory sites in a variety of autoimmune diseases including multiple sclerosis (MS). In this study, we used a murine model of MS, experimental allergic encephalomyeliti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6606a22daa05a4bc9456afd176f38a3d
http://europepmc.org/articles/PMC2192487

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Post-capillary venules in the 'milky spots' of the greater omentum are the major site of plasma protein and leukocyte extravasation in rodent models of peritonitis

Autor: J P Hakkinen, D N Scampoli, N S Doherty, R. J. Griffiths, A J Milici

Publikováno v: Inflammation Research. 44:169-177

Intraperitoneal injection of inflammatory agents in the mouse and rat causes plasma protein and leukocyte extravasation into the peritoneal cavity. Following an intraperitoneal injection of zymosan A, the milky spots of the omentum were the only abdo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c76ed7a8a62997fa3f62bc66ec305b
https://doi.org/10.1007/bf01782815

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The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543

Autor: H J, Showell, M J, Conklyn, R, Alpert, G P, Hingorani, K F, Wright, M A, Smith, E, Stam, E D, Salter, D N, Scampoli, S, Meltzer, L A, Reiter, K, Koch, A D, Piscopio, S R, Cortina, A, Lopez-Anaya, E R, Pettipher, A J, Milici, R J, Griffiths

Publikováno v: The Journal of pharmacology and experimental therapeutics. 285(3)

CP-195543 [(+)-2-(3-benzyl-4-hydroxy-chroman-7-yl)-4-trifluoromethyl-benzoic acid] is a structurally novel, selective and potent leukotriene B4 (LTB4) receptor antagonist. In vitro CP-195543 inhibited [3H]LTB4 binding to high-affinity LTB4 receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8820a50f6b81802f34218a6f301f753
https://pubmed.ncbi.nlm.nih.gov/9618393

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Effects of exercise on synovium and cartilage from normal and inflamed knees

Autor: Marcia L. Bliven, A J Milici, D N Scampoli, Ivan G. Otterness, A K Shay

Publikováno v: Rheumatology international. 14(5)

The effect of running activity on normal and inflamed knees was determined by light microscopic (LM) and scanning electron microscopic (SEM) observations on hamster articular cartilage. Animals were split into two groups; one housed in standard cages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d340ad26cf59a9ca273642ceccc9761c
https://pubmed.ncbi.nlm.nih.gov/7724994

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