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TRIMETAZIDINE PREVENTS RENAL INJURY IN THE ISOLATED PERFUSED PIG KIDNEY EXPOSED TO PROLONGED COLD ISCHEMIA1

Autor: D. Mothes, Jean-Michel Goujon, Laurence Le Moyec, Jean-Paul Tillement, Michel Carretier, Michel Eugene, J.C. Caritez, Thierry Hauet

Publikováno v: Transplantation. 64:1082-1086

Background. Ischemia caused by cold storage (CS) and reperfusion of the kidney is often responsible for delayed graft function after transplantation. Significant attention has been focused on the cascade of events involved in ischemia-reperfusion inj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07cb3fe5f3e97ae43667bfe7885225ea
https://doi.org/10.1097/00007890-199710150-00025

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Evaluation of Normothermic Ischemia and Simple Cold Preservation Injury in Pig Kidney by Proton Nuclear Magnetic Resonance Spectroscopy

Autor: Jean Michel Goujon, Michel Eugene, J.C. Caritez, D. Mothes, Thierry Hauet, Laurence Le Moyec, Michel Carretier

Publikováno v: Journal of Surgical Research. 68:116-125

The isolated perfused pig kidney (IPK) model was used to mimic the non-heart-beating donor situation. This model was performed to assess initial renal functions after normothermic ischemia, cold flush, and 24 hr cold-storage preservation (CSP) with E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca68f15b8954d929fad14dfdf57779d
https://doi.org/10.1006/jsre.1996.4988

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Beneficial effects of a low-potassium+ and polyethylene glycol solution on renal function and structure during 48-hour cold storage preservation

Autor: J.C. Caritez, Michel Carretier, Jean-Michel Goujon, Michel Eugene, L. Le Moyec, D. Mothes, Thierry Hauet

Publikováno v: Transplantation Proceedings. 29:2360-2362

ALTHOUGH the success of the first cold storage solution was attributed to its intracellular composition with low sodium and high potassium,1,2 the importance of impermeant agents has been shown and the potential deleterious effects of high potassium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9c2e9ddd751ba8adeff1fec7eb0a38
https://doi.org/10.1016/s0041-1345(97)00403-x

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Trimetazidine reverses deleterious effects of ischemia-reperfusion in the isolated perfused pig kidney model

Autor: J.C. Caritez, D. Mothes, Michel Carretier, Michel Eugene, Thierry Hauet, Jean-Michel Goujon, Thierry Germonville, Jean-Paul Tillement

Publikováno v: Nephron. 80(3)

Background: Delayed graft function has remained an important complication after renal transplantation. Methods: The purpose of this study was to evaluate Euro-Collins (EC) plus trimetazidine (TMZ) in comparison with standard EC solution after 24- or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9861a5eba790ee055353e92f6636a7f0
https://pubmed.ncbi.nlm.nih.gov/9807039

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Trimetazidine prevents renal injury in the isolated perfused pig kidney exposed to prolonged cold ischemia

Autor: T, Hauet, D, Mothes, J M, Goujon, J C, Caritez, M, Carretier, L, le Moyec, M, Eugene, J P, Tillement

Publikováno v: Transplantation. 64(7)

Ischemia caused by cold storage (CS) and reperfusion of the kidney is often responsible for delayed graft function after transplantation. Significant attention has been focused on the cascade of events involved in ischemia-reperfusion injury, with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71a7824db944801a8f425e1c6e353aef
https://pubmed.ncbi.nlm.nih.gov/9381535

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Evaluation of injury preservation in pig kidney cold storage by proton nuclear magnetic resonance spectroscopy of urine

Autor: J.C. Caritez, Thierry Hauet, Jean Michel Goujon, Michel Carretier, Michel Eugene, D. Mothes

Publikováno v: The Journal of urology. 157(3)

The isolated perfused kidney (IPK) model from pig was used to assess initial renal functions after cold flush and a 24- and 48-hour cold storage preservation (CSP) with Euro-Collins (EC) and to determine ischemia reperfusion (IR) impairment by bioche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0922acdf5e104ac53486b05289417ddc
https://pubmed.ncbi.nlm.nih.gov/9072561

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Beneficial effect on rat kidney preservation of the antiischemic agent trimetazidine during cold storage and reperfusion : assessment by 31P Nuclear Magnetic Resonance Spectroscopy

Autor: Jean-Paul Tillement, J.C. Caritez, L. Le Moyec, B. Dore, Guy Bauza, Michel Carretier, M. Eugene, Jean-Michel Goujon, D. Mothes, Thierry Hauet

Publikováno v: Transplantation Proceedings
Transplantation Proceedings, Elsevier, 1997, 29, pp.2343-2344

IN RENAL transplantation, delayed graft function remains a major problem and increases the posttransplant morbidity and hospital costs. Trimetazidine (TMZ), an antiischemic drug, was introduced several years ago and used as an antianginal agent whose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edda35679d281f9dee1375b0163fd03a
https://hal.inrae.fr/hal-02687996

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[Technique for protecting the liver graft less tolerant than the small bowel to heat-induced ischemia in experimental liver + small bowel transplantation in swine]

Autor: J P, Richer, J P, Faure, T, Dugue, F, Journe, D, Bon, N, Maillot, D, Mothes, J, Barbier, M, Carretier

Publikováno v: Chirurgie; memoires de l'Academie de chirurgie. 122(8-9)

Multivisceral and orthotopic liver/small bowel transplantations have been performed to treat patients with intestinal failure associated with liver failure induced by parenteral nutrition. The aim of this experimental study was to determine the exper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a90be3886f4adc8f8a9164208928ab34
https://pubmed.ncbi.nlm.nih.gov/9616894

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Proton NMR spectroscopy as a novel approach to the monitoring of citrate and trimethylamine-N-oxyde excretion after kidney preservation

Autor: Hervé Baumert, J.C. Caritez, R. Robert, Thierry Hauet, L. Le Moyec, Michel Carretier, Jean-Michel Goujon, D. Bon, Michel Eugene, C. Tallineau, D. Mothes

Publikováno v: Transplantation Proceedings
Transplantation Proceedings, Elsevier, 1997, 29, pp.2323-2325

HIGH resolution protin nuclear magnetic resonance (NMR) spectroscopy can be used for the rapid multicomponent analysis of low molecular weight metabolites in biologic fluids such as plasma and urine. Citrate (Cit) is an organic acid normally found in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96748fc64231c21f163cdd11cb7ba9b4
https://hal.inrae.fr/hal-02688681

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Renal handling of citrate excretion during reperfusion after cold storage in the isolated perfused pig kidney

Autor: Jean-Michel Goujon, D. Mothes, Raymond Robert, J. C. Carites, T. Hauet, P Badia, M. Eugene

Publikováno v: Late Graft Loss ISBN: 9789401062862
Transplantation and Clinical Immunology
28. Conference on transplantation and clinical immunology
28. Conference on transplantation and clinical immunology, Jun 1996, Lyon, France

Citrate (Cit) is an organic acid normally found in urine and a central component of the tricarboxylic acid cycle. Changes in renal metabolism have been proposed to cause dramatic changes in Cit excretion with acid-base imbalances. Cold ischemia stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe8c3a8d40a0b839a32c89cc1ec5d33
https://hal.inrae.fr/hal-02766765

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