Zobrazeno 1 - 10
of 697
pro vyhledávání: '"D. Monk"'
Autor:
Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Clare Newall, Marcin Mankowski, Michael G. Crooks, Dave Singh, Rekha Chaudhuri, Brian Leaker, Kerry Lunn, Sophie Reynolds, Sarah Dudley, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic, Thomas MA Wilkinson
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Respiratory viral infections are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon-β is naturally produced in response to viral infection, limiting replication. This exploratory study aimed t
Externí odkaz:
https://doaj.org/article/0e45758b1a514217839b388bd5252764
Autor:
Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101695- (2024)
Summary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of simtuzumab (the humanized version of AB0023, a monoclonal
Externí odkaz:
https://doaj.org/article/28bf070de21f4af1b6319da757012509
Publikováno v:
Radiation, Vol 3, Iss 4, Pp 211-225 (2023)
Nuclear sites require regular measurements of the air, soil, and groundwater to ensure the safety of the surrounding environment from potentially hazardous levels of contamination. Although high-energy beta and gamma emitters can often be detected in
Externí odkaz:
https://doaj.org/article/d6b73a145ebe41549ba1416a1f0ad2b9
Autor:
Nick A Francis, Phillip D Monk, Jacqueline Nuttall, Thomas Oliver, Catherine Simpson, Jody L Brookes, Victoria J Tear, Angela G Thompson, Toby N Batten, Marcin Mankowski, Thomas MA Wilkinson
Publikováno v:
BJGP Open, Vol 7, Iss 4 (2023)
Background: Effective therapeutics given early to high-risk ambulatory patients with coronavirus disease 2019 (COVID-19) could improve outcomes and reduce overall healthcare burden. However, conducting site visits in non-hospitalised patients, who sh
Externí odkaz:
https://doaj.org/article/ce250c5f637c4c0a8fc6392c28c1c035
Autor:
Prasanna Jagannathan, Kara W. Chew, Mark J. Giganti, Michael D. Hughes, Carlee Moser, Mark J. Main, Phillip D. Monk, Arzhang Cyrus Javan, Jonathan Z. Li, Courtney V. Fletcher, Caitlyn McCarthy, David A. Wohl, Eric S. Daar, Joseph J. Eron, Judith S. Currier, Upinder Singh, Davey M. Smith, William Fischer, Kara Chew, David (Davey) Smith, Eric Daar, David Wohl, Judith Currier, Joseph Eron, Michael Hughes, Mark Giganti, Justin Ritz, Lara Hosey, Jhoanna Roa, Nilam Patel, Kelly Colsh, Irene Rwakazina, Justine Beck, Scott Sieg, Jonathan Li, Courtney Fletcher, Teresa Evering, Rachel Bender Ignacio, Sandra Cardoso, Katya Corado, Nikolaus Jilg, Alan Perelson, Sandy Pillay, Cynthia Riviere, Babafemi Taiwo, Joan Gottesman, Matthew Newell, Susan Pedersen, Joan Dragavon, Cheryl Jennings, Brian Greenfelder, William Murtaugh, Jan Kosmyna, Morgan Gapara, Akbar Shahkolahi, Gerald Pierone, Juliana Elliott, Jeffrey Jacobson, Leila Hojat, Julie Pasternak, Jonathan Berardi, Celine Arar, Yevgeniy Bukhman, Manish Jain, Eugene Bukhman, Sadia Shaik, Timothy Hatlen, Kelly Dooley, Becky Becker, Adaliah Wilkins, Jose Pérez, Eloy Roman, Heriberto Fernández, Keila Hoover, James Renfroe, Mauney Weldon, Genei Bougher, Carlos Malvestutto, Heather Harber, Robyn Cicarella, Gene Neytman, Jack Herman, Craig Herman, Mariam Aziz, Joan Swiatek, Divya Pathak, Madhu Choudhary, Jennifer Sullivano, Olayemi Osiyemi, Myriam Izquierdo, Odelsey Torna, Aleen Khodabakhshian, Samantha Fortier, Constance Benson, Steven Hendrickx, Rosemarie Ramirez, Anne Luetkemeyer, Suzanne Hendler, Dennis Dentoni-Lasofsky, Mario Castro, Leslie Spikes, Chase Hall, Jonathan Oakes, Amy James Loftis, Pablo Tebas, William Short, Sarah McGuffin, Chris Jonsson, Rachel Presti, Alem Haile
Publikováno v:
EClinicalMedicine, Vol 65, Iss , Pp 102250- (2023)
Summary: Background: With the emergence of SARS-CoV-2 variants resistant to monoclonal antibody therapies and limited global access to therapeutics, the evaluation of novel therapeutics to prevent progression to severe COVID-19 remains a critical nee
Externí odkaz:
https://doaj.org/article/454735c4a8b341a688fdabe4d9bc0450
Autor:
Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Marcin Mankowski, Tatjana Adzic-Vukicevic, Michael G. Crooks, Davinder P.S. Dosanjh, Monica Kraft, Christopher E. Brightling, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic, Tom M.A. Wilkinson
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background Despite the availability of vaccines and therapies, patients are being hospitalised with coronavirus disease 2019 (COVID-19). Interferon (IFN)-β is a naturally occurring protein that stimulates host immune responses against most viruses,
Externí odkaz:
https://doaj.org/article/59ef7b2928b0495c936fac3cc3b5d606
Autor:
Tomas Fried, Antonio Di Buono, David Cheneler, Neil Cockbain, Jonathan M. Dodds, Peter R. Green, Barry Lennox, C. James Taylor, Stephen D. Monk
Publikováno v:
Nuclear Engineering and Technology, Vol 53, Iss 10, Pp 3335-3343 (2021)
The impact of gamma radiation on a commercial off the shelf microcontroller board has been investigated. Three different tests have been performed to ascertain the radiation tolerance of the device from a nuclear decommissioning deployment perspectiv
Externí odkaz:
https://doaj.org/article/17c8dad9c3d445bd857396074b8d6a2d
Publikováno v:
Sensors, Vol 23, Iss 8, p 4053 (2023)
A compact back-end interface for silicon photomultipliers (SiPMs) implementing Zener diode-based temperature compensation has been developed for the remote detection of beta and gamma radiation. Remote detection is facilitated by the development of a
Externí odkaz:
https://doaj.org/article/3f9b4323d393426c9f945e6fee83061b
Autor:
Hannah S. Alpert, David A. Saunders, Milad Mahzari, Joshua D. Monk, Todd R. White, Thomas K. West
Publikováno v:
Journal of Spacecraft and Rockets. 60:899-911
The Mars Entry, Descent, and Landing Instrumentation 2 (MEDLI2) sensor suite collected heating and pressure data during entry of the Mars 2020 Perseverance rover into Mars’s atmosphere. MEDLI2 included temperature, heat flux, and pressure sensors o
Autor:
Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Marcin Mankowski, Tatjana Adzic-Vukicevic, Michael G. Crooks, Davinder P.S. Dosanjh, Monica Kraft, Christopher E. Brightling, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic, Tom M.A. Wilkinson
Publikováno v:
ERJ Open Research. 9:00605-2022
BackgroundDespite the availability of vaccines and therapies, patients are being hospitalised with coronavirus disease 2019 (COVID-19). Interferon (IFN)-β is a naturally occurring protein that stimulates host immune responses against most viruses, i