Antimicrobial activity of the recombinant designer host defence peptide P-novispirin G10 in infected full-thickness wounds of porcine skin

Autor: Tobias Hirsch, Hans-Ulrich Steinau, Dorotea Raventós, Lars Steinstraesser, A. Mohammadi-Tabrisi, Adrien Daigeler, M. Lehnhardt, Per Holse Mygind, Carsten P. Sönksen, Frank Jacobsen, Sören Gatermann, D. Mittler, Hans-Henrik Kristensen

Publikováno v: Europe PubMed Central

Objectives The growing number of patients with impaired wound healing and the development of multidrug-resistant bacteria demand the investigation of alternatives in wound care. The antimicrobial activity of naturally occurring host defence peptides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e83b73e34be6cda69be2f7bf04ea51d
https://doi.org/10.1093/jac/dkl513

Activity of histone H1.2 in infected burn wounds

Autor: Frank Jacobsen, Sören Gatermann, A. Baraniskin, Hans-Ulrich Steinau, Lars Steinstraesser, M. Soltau, B. Behnke, D. Mittler, M. Lehnhardt, S. Schubert, J. Mertens, A. Mohammadi-Tabrisi

Publikováno v: Journal of Antimicrobial Chemotherapy. 55:735-741

Objectives Infections with multidrug-resistant microorganisms (e.g. Pseudomonas aeruginosa and Staphylococcus aureus) cause immense complications in wound care and in the treatment of immunosuppressed patients. Like most antimicrobial peptides, histo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de83cd2343ebabdc29441def10e78313
https://doi.org/10.1093/jac/dki067

Kutane adenovirale Gentherapie mit humanem Host Defense Peptid LL-37 in infizierten Verbrennungswunden der Ratte

Autor: Tobias Hirsch, Lars Steinstraesser, Michael Sorkin, M. Lehnhardt, Frank Jacobsen, Hans-Ulrich Steinau, D. Mittler, A. Gerhards

Publikováno v: 123. Kongress der Deutschen Gesellschaft für Chirurgie; 20060502-20060505; Berlin; DOC06dgch5109 /20060502/
Chirurgisches Forum 2006 ISBN: 9783540324805

Die durchgefuhrte Studie konnte zeigen, dass der kutane adenovirale Gentransfer mit humanen Host Defense Peptiden signifikant bessere und verlangerte antimikrobielle Wirksamkeit aufweist und damit eine interessante Therapieoption in der Behandlung vo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423ec61fa4673a3559c00796eaf129a4
http://www.egms.de/en/meetings/dgch2006/06dgch385.shtml

Transient cutaneous adenoviral gene therapy with human host defense peptide hCAP-18/LL-37 is effective for the treatment of burn wound infections

Autor: D. Mittler, Bruno Voss, Tobias Hirsch, M. Lehnhardt, A. Gerhards, Frank Jacobsen, Hans-Ulrich Steinau, Lars Steinstraesser

Publikováno v: Gene therapy. 12(20)

Host defense peptides (HDP) are naturally occurring effector molecules of the innate immune system, which might be an alternative to currently used antibiotics. The objective of this study was to investigate the efficiency of transient cutaneous aden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0a5147cec04953f1e5727794c251bd
https://pubmed.ncbi.nlm.nih.gov/15973442

787. Cationic Lipids Improve Transfection Efficacy of Recombinant Replication Deficient Adenovirus in Cutaneous Cells

Autor: D. Mittler, Frank Jacobsen, Hans U. Steinau, Lars Steinstraesser, Tobias Hirsch

Publikováno v: Molecular Therapy. 9:S298-S299

Introduction: The use of replication deficient adenovirus vectors for the delivery of therapeutic genes to treat human disease has progressed rapidly in the last ten years. The aim of this study was to evaluate and optimize the adenoviral vector syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66eb78f0c621536d257277da7967a705
https://doi.org/10.1016/j.ymthe.2004.06.877