Zobrazeno 1 - 10
of 781
pro vyhledávání: '"D. Michaels"'
Autor:
Zhen Wang, Claudia M. Castillo-González, Changjiang Zhao, Chun-Yip Tong, Changhao Li, Songxiao Zhong, Zhiyang Liu, Kaili Xie, Jiaying Zhu, Zhongshou Wu, Xu Peng, Yannick Jacob, Scott D. Michaels, Steven E. Jacobsen, Xiuren Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The H3 methyltransferases ATXR5 and ATXR6 deposit H3.1K27me1 to heterochromatin to prevent genomic instability and transposon re-activation. Here, we report that atxr5 atxr6 mutants display robust resistance to Geminivirus. The viral resista
Externí odkaz:
https://doaj.org/article/8592bad5b0d24d13a6cc15d3c8d43320
Autor:
Jon D. Michaels
Americans have a love-hate relationship with government. Rejecting bureaucracy—but not the goods and services the welfare state provides—Americans have demanded that government be made to run like a business. Hence today's privatization revolutio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In plants, 3′ Pol II pausing helps prevent transcriptional interference. Here the authors provide evidence that BORDER proteins are enriched in intergenic regions and inhibit transcriptional interference between closely spaced genes by preventing R
Externí odkaz:
https://doaj.org/article/cca32344f99e4f9892623ebc478613c3
Autor:
Matthew T Parker, Katarzyna Knop, Vasiliki Zacharaki, Anna V Sherwood, Daniel Tomé, Xuhong Yu, Pascal GP Martin, Jim Beynon, Scott D Michaels, Geoffrey J Barton, Gordon G Simpson
Publikováno v:
eLife, Vol 10 (2021)
Genes involved in disease resistance are some of the fastest evolving and most diverse components of genomes. Large numbers of nucleotide-binding, leucine-rich repeat (NLR) genes are found in plant genomes and are required for disease resistance. How
Externí odkaz:
https://doaj.org/article/a93848093b644c9b91f021cb3118bfcf
Autor:
Karol Szlachta, Cem Kuscu, Turan Tufan, Sara J. Adair, Stephen Shang, Alex D. Michaels, Matthew G. Mullen, Natasha Lopes Fischer, Jiekun Yang, Limin Liu, Prasad Trivedi, Edward B. Stelow, P. Todd Stukenberg, J. Thomas Parsons, Todd W. Bauer, Mazhar Adli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Predicting the response to chemotherapy is a major goal of cancer research. Here the authors use CRISPR knockout screens in pancreatic ductal adenocarcinoma cells to identify deletions synergistic with MEK inhibitors.
Externí odkaz:
https://doaj.org/article/5878576fa2b34029942f52a332a9c423
Autor:
D Michaels, I Couper, Z Talib, M Mogodi, J Hakim, A Matsika, M Simuyemba, M Mipando, M Chidzonga
Publikováno v:
African Journal of Health Professions Education, Vol 9, Iss 3, Pp 138-143 (2017)
Background. The University of Zimbabwe College of Health Sciences (UZCHS), Harare, which has a long tradition of community-based education (CBE), has not been evaluated since 1991. An innovative approach was used to evaluate the programme during 2015
Externí odkaz:
https://doaj.org/article/67215b246cbc4948a705529cb4d35e3c
Autor:
H. Kadosh, D. Michaels
Publikováno v:
Shock Waves. 32:353-362
Autor:
Sarbajeet Nagdas, Jennifer A. Kashatus, Aldo Nascimento, Syed S. Hussain, Riley E. Trainor, Sarah R. Pollock, Sara J. Adair, Alex D. Michaels, Hiromi Sesaki, Edward B. Stelow, Todd W. Bauer, David F. Kashatus
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1845-1859.e5 (2019)
Summary: Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes mitochondrial fragmentation and tumor growth through Erk
Externí odkaz:
https://doaj.org/article/3897e3f059e04a41b0a0865493500ca3
Supplemental legend from CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer
Autor:
Todd W. Bauer, J. Thomas Parsons, Kodi S. Ravichandran, Craig L. Slingluff, Timothy N. J. Bullock, Jesse B. Persily, Matthew G. Mullen, Sarbajeet Nagdas, Bernadette J. Goudreau, Sho Morioka, Sara J. Adair, Timothy E. Newhook, Alex D. Michaels
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ae90723b16bb6d9c0fa3c8ab5df2c9
https://doi.org/10.1158/1078-0432.22460652.v1
https://doi.org/10.1158/1078-0432.22460652.v1
Autor:
Todd W. Bauer, J. Thomas Parsons, Kodi S. Ravichandran, Craig L. Slingluff, Timothy N. J. Bullock, Jesse B. Persily, Matthew G. Mullen, Sarbajeet Nagdas, Bernadette J. Goudreau, Sho Morioka, Sara J. Adair, Timothy E. Newhook, Alex D. Michaels
Purpose: Patients with pancreatic ductal adenocarcinoma (PDAC) who undergo surgical resection and adjuvant chemotherapy have an expected survival of only 2 years due to disease recurrence, frequently in the liver. We investigated the role of liver ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939bd162b8d708e254072e5725e6b404
https://doi.org/10.1158/1078-0432.c.6524556.v1
https://doi.org/10.1158/1078-0432.c.6524556.v1