Zobrazeno 1 - 10
of 31
pro vyhledávání: '"D. Michael Shasby"'
Autor:
Cecilia L. Chin, Katherine J. D. A. Excoffon, Alicia L. Humlicek, Dwight C. Look, Lori J. Manzel, Lei Shi, D. Michael Shasby, Michael C. Winter
Publikováno v:
The Journal of Immunology. 178:6395-6403
Respiratory pathogens and toxins often assault the lung from the airway lumen. Airway epithelia may initiate and amplify inflammation in response to these attacks, but under certain conditions confinement of inflammation to the airway lumen may be be
Autor:
D. Michael Shasby
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 292:L593-L607
Homotypic cell-cell adhesion is essential for tissue and organ development, remodeling, regeneration, and physiological function. Whereas a significant number of homotypic cell-cell adhesion molecules have been identified, much more is known about th
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 291:L628-L635
The airway epithelium is an important barrier between the environment and subepithelial tissues. The epithelium is also divided into functionally restricted apical and basolateral domains, and this restriction is dependent on the elements of the barr
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 287:L816-L823
Histamine is an important agent of innate immunity, transiently increasing the flux of immune-competent molecules from the vascular space to the tissues and then allowing rapid restoration of the integrity of the endothelial barrier. In previous work
Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 282:L1330-L1338
Histamine increases microvascular permeability by creating small transitory (100-400 nm) gaps between adjacent endothelial cells at sites of vascular endothelial (VE)-cadherin-based adhesion. We examined the effects of histamine on the proteins withi
Autor:
Pavál Babal, Judy Creighton, Troy Stevens, Timothy Moore, D. Michael Shasby, Natalie R. Norwood, George H. Brough
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 279:L691-L698
The present study evaluated the necessity of store-operated Ca2+entry in mediating thrombin-induced 20-kDa myosin light chain (MLC20) phosphorylation and increased permeability in bovine pulmonary artery endothelial cells (BPAECs). Thrombin (7 U/ml)
Autor:
D. Michael Shasby, Mary C. Williams
Publikováno v:
Journal of Aerosol Medicine. 7:19-24
Publikováno v:
Chest. 121(1)
A 19-year-old woman presented with purpura fulminans and septic shock; subsequently, progressive coagulopathy, widespread purpura fulminans associated with meningococcemia, severe shock, respiratory, and renal failure developed. This clinical course
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 279(3)
Endothelium forms a physical barrier that separates blood from tissue. Communication between blood and tissue occurs through the delivery of molecules and circulating substances across the endothelial barrier by directed transport either through or b
Autor:
Yih-Tai Chen, Sandra S. Shasby, Anant Kamath, D. Michael Shasby, Dana R. Ries, Michael C. Winter
Publikováno v:
The American journal of physiology. 277(5)
We tested the hypothesis that histamine alters the focal apposition of endothelial cells by acting on sites of cadherin-mediated cell-cell adhesion. Focal apposition was measured as the impedance of a cell-covered electrode, which was partitioned int