Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension

Autor: Xue D. Manz, Robert Szulcek, Xiaoke Pan, Petr Symersky, Chris Dickhoff, Jisca Majolée, Veerle Kremer, Elisabetta Michielon, Ekaterina S. Jordanova, Teodora Radonic, Irene V. Bijnsdorp, Sander R. Piersma, Thang V. Pham, Connie R. Jimenez, Anton Vonk Noordegraaf, Frances S. de Man, Reinier A. Boon, Jan Voorberg, Peter L. Hordijk, Jurjan Aman, Harm Jan Bogaard

Publikováno v: American journal of respiratory and critical care medicine, 205(7), 808-818. American Thoracic Society
Manz, X D, Szulcek, R, Pan, X, Symersky, P, Dickhoff, C, Majolee, J, Kremer, V, Michielon, E, Jordanova, E S, Radonic, T, Bijnsdorp, I V, Piersma, S R, Pham, T V, Jimenez, C R, Noordegraaf, A V, de Man, F S, Boon, R A, Voorberg, J, Hordijk, P L, Aman, J & Bogaard, H J 2022, ' Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension ', American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 7, pp. 806-818 . https://doi.org/10.1164/rccm.202109-2075OC
American Journal of Respiratory and Critical Care Medicine, 205(7), 806-818. American Thoracic Society

Rationale: von Willebrand factor (vWF) mediates platelet adhesion during thrombosis. While chronic thromboembolic pulmonary hypertension (CTEPH) is associated with increased plasma levels of vWF, the role of this protein in CTEPH has remained enigmat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e382bcba5e7d072452cae1dd7c7f50
http://www.scopus.com/inward/record.url?scp=85128000994&partnerID=8YFLogxK

C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration

Autor: Leonie Hartl, Pien A. F. Maarschalkerweerd, Joe M. Butler, Xue D. Manz, Victor L. J. L. Thijssen, Maarten F. Bijlsma, JanWillem Duitman, C. Arnold Spek

Publikováno v: Cells; Volume 11; Issue 21; Pages: 3334
Hartl, L, Maarschalkerweerd, P A F, Butler, J M, Manz, X D, Thijssen, V L J L, Bijlsma, M F, Duitman, J & Spek, C A 2022, ' C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration ', Cells, vol. 11, no. 21, 3334 . https://doi.org/10.3390/cells11213334
Cells, 11(21):3334. MDPI Multidisciplinary Digital Publishing Institute

Pancreatic Ductal Adenocarcinoma (PDAC) is among the most aggressive human cancers and occurs globally at an increasing incidence. Metastases are the primary cause of cancer-related death and, in the majority of cases, PDAC is accompanied by metastat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2933814070111415962a3be0eb511d
http://www.scopus.com/inward/record.url?scp=85141556910&partnerID=8YFLogxK

Identification of a potent and selective covalent Pin1 inhibitor

Autor: Kun Ping Lu, Hyuk-Soo Seo, Yujin Chun, Christopher M. Browne, Theresa D. Manz, Xiao Zhen Zhou, Zainab M. Doctor, Xiaolan Lian, Zoe C. Yeoh, Shin Kibe, Scott B. Ficarro, Nir London, Benika J. Pinch, Nicholas E. Vangos, Behnam Nabet, Stephen Buratowski, Dina Daitchman, Shingo Kozono, Daniel Zaidman, Nathanael S. Gray, Jarrod A. Marto, Mikaela L. Mohardt, Li Tan, Sirano Dhe-Paganon, Ezekiel A. Geffken

Publikováno v: Nature chemical biology

Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in human cancers, including pancreatic ductal adenocarcinoma (PDAC). While Pin1 is dispensable for viability in mice, it is required for activated Ras to induce t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6565cbd6de180dcf92ba1d74b5e545e0
https://doi.org/10.1038/s41589-020-0550-9

Discovery and Structure–Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors

Autor: Theresa D. Manz, Tinghu Zhang, Anton Simeonov, Chandrasekhar V. Miduturu, Lewis C. Cantley, Adam Yasgar, Hyeseok Shim, Nathanael S. Gray, Sirano Dhe-Paganon, Sindhu Carmen Sivakumaren, Joseph D. Card, Scott B. Ficarro, Min Shen, Hyuk-Soo Seo, Jarrod A. Marto, Matthew D. Hall, Fleur M. Ferguson

Publikováno v: Journal of Medicinal Chemistry. 63:4880-4895

Due to their role in many important signaling pathways, phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are attractive targets for the development of experimental therapeutics for cancer, metabolic, and immunological disorders. Recent efforts to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43a16faa83e838e7b651e0a9e516b30d
https://doi.org/10.1021/acs.jmedchem.0c00227

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Autor: Korneliusz Golebski, Federica Linty, Harm Jan Bogaard, Guillermo R. Griffith, Godelieve J. de Bree, Marit J. van Gils, Willianne Hoepel, Tom G. Caniels, Lynn Mes, Hung-Jen Chen, Frank E.H.P. van Baarle, Cornelis M. van Drunen, René E. Jonkers, Jurjan Aman, Sona Allahverdiyeva, Menno P.J. de Winther, Jeroen den Dunnen, Karlijn van der Straten, Manfred Wuhrer, Mads Delbo Larsen, Gestur Vidarsson, Jan Nouta, Rogier W. Sanders, Theo Rispens, Alexander P.J. Vlaar, Maurice Steenhuis, Gertjan Wolbink, Diederik van de Beek, Philip J. M. Brouwer, Xue D. Manz, Cindy P. A. A. van Roomen, Peter I. Bonta, Chiara Elisabeth Geyer, Annette E. Neele, Lisa Willemsen, Steven W. de Taeye

Publikováno v: Science Translational Medicine, 13(596):eabf8654. American Association for the Advancement of Science
Hoepel, W, Chen, H-J, Geyer, C E, Allahverdiyeva, S, Manz, X D, de Taeye, S W, Aman, J, Mes, L, Steenhuis, M, Griffith, G R, Bonta, P I, Brouwer, P J M, Caniels, T G, van der Straten, K, Golebski, K, Jonkers, R E, Larsen, M D, Linty, F, Nouta, J, van Roomen, C P A A, van Baarle, F E H P, van Drunen, C M, Wolbink, G, Vlaar, A P J, de Bree, G J, Sanders, R W, Willemsen, L, Neele, A E, van de Beek, D, Rispens, T, Wuhrer, M, Bogaard, H J, van Gils, M J, Vidarsson, G, de Winther, M & den Dunnen, J 2021, ' High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages ', Science Translational Medicine, vol. 13, no. 596, eabf8654 . https://doi.org/10.1126/scitranslmed.abf8654
Science Translational Medicine
Science Translational Medicine, 13(596). AMER ASSOC ADVANCEMENT SCIENCE
Science translational medicine, 13(596):eabf8654. American Association for the Advancement of Science

High titers and low fucosylation of human anti-spike protein IgG promote alveolar macrophage activation and inflammation.
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3776bc2b7ca6cf18e6e8c677efa6c2a
https://research.vumc.nl/en/publications/9c41a896-d9c0-4ca8-a875-c845ffd899e8