Zobrazeno 1 - 10
of 677
pro vyhledávání: '"D. MIDDLEMISS"'
Autor:
Prateek Sharma, James R. J. Haycocks, Alistair D. Middlemiss, Rachel A. Kettles, Laura E. Sellars, Vito Ricci, Laura J. V. Piddock, David C. Grainger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Transcription factors MarR and MarA confer multidrug resistance in enteric bacteria by modulating efflux pump and porin expression. Here, Sharma et al. show that MarA also upregulates genes required for lipid trafficking and DNA repair, thus reducing
Externí odkaz:
https://doaj.org/article/4669c1bf8a8f4a01bd835687185dcfd1
Autor:
Alistair D. Middlemiss, Emily A. Warman, David Forrest, James R. J. Haycocks, David C. Grainger
Publikováno v:
Microbiology. 169
Transcription of the DNA template, to generate an RNA message, is the first step in gene expression. The process initiates at DNA sequences called promoters. Conventionally, promoters have been considered to drive transcription in a specific directio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60392e7f2a33cc2e78b3ab383855aea5
https://doi.org/10.1099/mic.0.001339
https://doi.org/10.1099/mic.0.001339
Autor:
Alistair D. Middlemiss, James R. J. Haycocks, Anne M. Stringer, Laura J. V. Piddock, Joseph T. Wade, David C. Grainger
Publikováno v:
Microbiology. 169
The closely related transcription factors MarA, SoxS, Rob and RamA control overlapping stress responses in many enteric bacteria. Furthermore, constitutive expression of such regulators is linked to clinical antibiotic resistance. In this work we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aea142a4c141d4f7448342808cc6478b
https://doi.org/10.1099/mic.0.001330
https://doi.org/10.1099/mic.0.001330
Akademický článek
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Akademický článek
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Autor:
Nishi Gupta, Arthur D. Middlemiss
Publikováno v:
Journal of Financial Crime. 14:138-149
PurposeThis paper aims to illustrate by example the value of interagency cooperation between US and international law enforcement and regulatory agencies.Design/methodology/approachGeneral review of post‐9/11 criminal cases brought by the Manhattan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9520d85cc5fd0bdc865b4f28a8ca8b9
https://doi.org/10.1108/13590790710742636
https://doi.org/10.1108/13590790710742636
Autor:
D B, Judd, M D, Dowle, D, Middlemiss, D I, Scopes, B C, Ross, T I, Jack, M, Pass, E, Tranquillini, J E, Hobson, T A, Panchal
Publikováno v:
Journal of Medicinal Chemistry. 37:3108-3120
We have identified GR138950, a potent antagonist of the angiotensin II receptor with high oral bioavailability, as our second drug candidate to GR117289. Using GR117289, a compound with moderate bioavailability (20%) in man as a lead, we pursued a st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742a0d724baef5715fde493974209c4b
https://doi.org/10.1021/jm00045a016
https://doi.org/10.1021/jm00045a016
Publikováno v:
Advanced Science. 8/7/2024, Vol. 11 Issue 29, p1-7. 7p.
Autor:
Liu, Jiani1 (AUTHOR), Song, Junyi1 (AUTHOR) songjunyi@nudt.edu.cn, Zeng, Ling1 (AUTHOR), Hu, Biru1 (AUTHOR) songjunyi@nudt.edu.cn
Publikováno v:
International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7994. 20p.
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbcff86b42c2ad9b5c48fa831e675eae
https://doi.org/10.1002/chin.199602133
https://doi.org/10.1002/chin.199602133