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Akademický článek

N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness

Autor: Allison M. Meadows, Kim Han, Komudi Singh, Antonio Murgia, Ben D. McNally, James A. West, Rebecca D. Huffstutler, Tiffany M. Powell-Wiley, Yvonne Baumer, Julian L. Griffin, Michael N. Sack

Publikováno v: iScience, Vol 26, Iss 5, Pp 106578- (2023)

Summary: Caloric deprivation interventions such as intermittent fasting and caloric restriction ameliorate metabolic and inflammatory disease. As a human model of caloric deprivation, a 24-h fast blunts innate and adaptive immune cell responsiveness

Externí odkaz: https://doaj.org/article/72dbf0ea57894d6e93e19b9ad9554f69

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Akademický článek

Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle

Autor: Ben D. McNally, Dean F. Ashley, Lea Hänschke, Hélène N. Daou, Nicole T. Watt, Steven A. Murfitt, Amanda D. V. MacCannell, Anna Whitehead, T. Scott Bowen, Francis W. B. Sanders, Michele Vacca, Klaus K. Witte, Graeme R. Davies, Reinhard Bauer, Julian L. Griffin, Lee D. Roberts

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activatio

Externí odkaz: https://doaj.org/article/e431ba3360bc41d78c30c04a825835be

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Akademický článek

Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress

Autor: Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)

Abstract Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting i

Externí odkaz: https://doaj.org/article/e6fa613deccb4bec8cc1aae51e72dedf

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Akademický článek

Evaluation of antibiotic treatment decisions in pediatric intensive care units in Saudi Arabia: A national survey

Autor: Yasser M. Kazzaz, Musaed Alharbi, Kim C. Nöel, Caroline Quach, Douglas F. Willson, Elaine Gilfoyle, James D. McNally, Shauna O’Donnell, Jesse Papenburg, Jacques Lacroix, Patricia S. Fontela

Publikováno v: Journal of Infection and Public Health, Vol 14, Iss 9, Pp 1254-1262 (2021)

Objective: To describe variables used by Saudi pediatric intensivists to make antibiotic-related decisions for children with suspected severe bacterial infections. Methods: We conducted a cross-sectional survey, which was developed using a multi-step

Externí odkaz: https://doaj.org/article/6dbc9d63c2d74735a03da957852f7332

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Akademický článek

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have ant

Externí odkaz: https://doaj.org/article/d473c1c97b044c2fb72f34ce9316e47f

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Akademický článek

Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness

Autor: Helen T. McKenna, Katie A. O'Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. McNally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin

Publikováno v: Redox Biology, Vol 41, Iss , Pp 101907- (2021)

Background: Numerous pathologies result in multiple-organ failure, which is thought to be a direct consequence of compromised cellular bioenergetic status. Neither the nature of this phenotype nor its relevance to survival are well understood, limiti

Externí odkaz: https://doaj.org/article/9c66267adf404de2a8e691584df51551

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Akademický článek

Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice

Autor: Alice P. Sowton, Nisha Padmanabhan, Simon J. Tunster, Ben D. McNally, Antonio Murgia, Aisha Yusuf, Julian L. Griffin, Andrew J. Murray, Erica D. Watson

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 23, Iss , Pp - (2020)

Nonalcoholic fatty liver disease (NAFLD) is associated with dietary folate deficiency and mutations in genes required for one‑carbon metabolism. However, the mechanism through which this occurs is unclear. To improve our understanding of this link,

Externí odkaz: https://doaj.org/article/b828d8c6f0654a398e8fa0e34097c012

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Akademický článek

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