Výsledky vyhledávání - "D. M. Shepherd"

Cognate interaction between T helper cells and B cells. VII. Role of contact and lymphokines in the expression of germ-line and mature gamma 1 transcripts

Autor: R J Noelle, D M Shepherd, H P Fell

Publikováno v: The Journal of Immunology. 149:1164-1169

Complete reconstitution of Th cell function for B cell growth and differentiation was provided by plasma membranes (PM) derived from activated Th (PMAct) in combination with IL-4 and IL-5 (IL-4/IL-5). IL-5 has been shown to be essential for the secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b17f3961b9a934e6e294a6a6fd79c7c
https://doi.org/10.4049/jimmunol.149.4.1164

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Cognate interactions between helper T cells and B cells. V. Reconstitution of T helper cell function using purified plasma membranes from activated Th1 and Th2 T helper cells and lymphokines

Autor: R J Noelle, J Daum, W C Bartlett, J McCann, D M Shepherd

Publikováno v: The Journal of Immunology. 146:1118-1124

Th physically interact with B cells and produce lymphokines that influence B cell growth and differentiation. The respective contribution of cell contact and lymphokines to induction of B cell growth and differentiation was addressed using purified p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67ea3817d542255e892f112335395364
https://doi.org/10.4049/jimmunol.146.4.1118

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Disruption of CD154:CD40 blocks generation of allograft immunity without affecting APC activation

Autor: D M, Shepherd, N I, Kerkvliet

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(5)

CD154 (CD40 ligand, gp39) interaction with its receptor CD40 has been shown to be critically important for the generation of cell-mediated as well as humoral immunity. It has been proposed that ligation of CD40 on APCs, presumably by activated Th cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37f01945ca35c8041ae8bd8daad15829
https://pubmed.ncbi.nlm.nih.gov/10452982

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Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Autor: N I, Kerkvliet, L, Baecher-Steppan, D M, Shepherd, J A, Oughton, B A, Vorderstrasse, G K, DeKrey

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 157(6)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant and prototypic ligand for the aryl hydrocarbon receptor, is a potent immunotoxicant. To understand the underlying mechanisms of TCDD immunotoxicity, we have characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a69c3ab10b53fc04d8804f05b488da8f
https://pubmed.ncbi.nlm.nih.gov/8805628

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Signaling events during helper T cell-dependent B cell activation. I. Analysis of the signal transduction pathways triggered by activated helper T cell in resting B cells

Autor: L S, Marshall, D M, Shepherd, J A, Ledbetter, A, Aruffo, R J, Noelle

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 152(10)

gp39 is expressed on anti-CD3-activated Th, and binds CD40 on the B cell, driving B cell cycle entry. In this study, the signal-transduction pathway initiated in B cells as a consequence of interacting with activated Th is examined. Unlike anti-membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36321149d9607aeeef868e6b1dea0c48
https://pubmed.ncbi.nlm.nih.gov/7513724

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