Zobrazeno 1 - 10
of 28
pro vyhledávání: '"D. M. Milne"'
Autor:
D M Milne, C. Hogan, Caroline Hutchison, David W. Meek, John R. Goodlad, Mark K. Saville, Neil M. Kernohan, Lynnette Marcar
Publikováno v:
Journal of Biological Chemistry. 283:18012-18023
Mutation of the p53 gene is a common event during tumor pathogenesis. Other mechanisms, such as mdm2 amplification, provide alternative routes through which dysfunction of the p53 pathway is promoted. Here, we address the hypothesis that elevated exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34a7fccaf7a77c2aa8bdf7e83e5d1b0
https://doi.org/10.1074/jbc.m709695200
https://doi.org/10.1074/jbc.m709695200
Publikováno v:
Molecular and Cellular Biochemistry. 274:85-90
The Murine double-minute clone 2 (Mdm2) onco-protein is the principal regulator of the tumour suppressor, p53. Mdm2 acts as an E3-type ubiquitin ligase that mediates the ubiquitylation and turnover of p53 under normal, unstressed circumstances. In re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99c5ab747eec179e130a2903e7280d3
https://doi.org/10.1007/s11010-005-3074-4
https://doi.org/10.1007/s11010-005-3074-4
Publikováno v:
Oncogene. 18:7602-7607
The p53 tumour suppressor protein is tightly regulated by protein-protein association, protein turnover and a variety of post-translational modifications. Multisite phosphorylation plays a major role in activating and in finely tuning p53 function. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ed0d2a10140385cbd72ca0b2bac14b
https://doi.org/10.1038/sj.onc.1203137
https://doi.org/10.1038/sj.onc.1203137
Publikováno v:
Biochemical Society Transactions. 25:416-419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac8a6c00e1ea6d2b23f5dbf322be024
https://doi.org/10.1042/bst0250416
https://doi.org/10.1042/bst0250416
Publikováno v:
Journal of Biological Chemistry. 270:5511-5518
The p53 tumor suppressor protein is thought to play a major role in the defense of the cell against agents that damage DNA. In this report, we describe the identification and characterization of a protein kinase that phosphorylates mouse p53 at a sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a878b67cc9fc731005ad67f3e6325df6
https://doi.org/10.1074/jbc.270.10.5511
https://doi.org/10.1074/jbc.270.10.5511
Autor:
J. Hopkins, F. J. Bryant, G. D. Johnson, D. S. A. Sanders, Michael A. Kerr, C. A. Wilson, D. M. Milne
Publikováno v:
Gut. 35:1022-1025
Using a panel of carcinoembryonic antigen (CEA) related antibodies in normal oesophageal squamous mucosa CEA expression is present on suprabasal squames localised to the cell membrane. Immunoblotting shows that this positivity is predominantly due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62057016359a981d3cb0f20651128bb
https://doi.org/10.1136/gut.35.8.1022
https://doi.org/10.1136/gut.35.8.1022
Publikováno v:
Journal of Biological Chemistry. 269:9253-9260
The p53 tumor suppressor protein is tightly regulated in the cell and is phosphorylated at multiple sites by several different protein kinases. We have investigated the phosphorylation of p53 by mitogen-activated protein (MAP) kinase, a protein kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e8dfca9d0c4b1e507e188b19dbebca6
https://doi.org/10.1016/s0021-9258(17)37101-6
https://doi.org/10.1016/s0021-9258(17)37101-6
Publikováno v:
Oncogene. 25(50)
The p53 tumour-suppressor protein is tightly regulated through its association with the Hdm2 E3 ligase. Activation of p53 by DNA strand breaks is orchestrated by the ataxia-telangiectasia mutated (ATM) protein kinase and involves interruption of Hdm2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9000f217c636a0f59aa96187b38d2990
https://pubmed.ncbi.nlm.nih.gov/16702947
https://pubmed.ncbi.nlm.nih.gov/16702947
Autor:
R. Kulikov, Christine Blattner, D M Milne, David W. Meek, Uwe Knippschild, Sylvia Dias, Markus Winter
Publikováno v:
Biochemistry. 43(51)
Murine double-minute clone 2 protein (MDM2) is an E3 ubiquitin ligase that regulates the turnover of several cellular factors including the p53 tumor suppressor protein. As part of the mechanism of p53 induction in response to DNA damage, a cluster o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8aff8a229e0a44bbc545b342f8cfb3
https://pubmed.ncbi.nlm.nih.gov/15610030
https://pubmed.ncbi.nlm.nih.gov/15610030
Autor:
Samantha M. Nicol, David W. Meek, Petros Kampanis, Frances V. Fuller-Pace, Sylvia Dias, David G. Campbell, D M Milne
Publikováno v:
FEBS letters. 577(1-2)
MDM2 is an E3 ubiquitin ligase which mediates ubiquitylation and proteasome-dependent degradation of the p53 tumor suppressor protein. Phosphorylation of MDM2 by the protein kinase AKT is thought to regulate MDM2 function in response to survival sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7519ae5d7f27cbb1dce3d898f153e0a9
https://pubmed.ncbi.nlm.nih.gov/15527798
https://pubmed.ncbi.nlm.nih.gov/15527798