Zobrazeno 1 - 10
of 24
pro vyhledávání: '"D. M. MONROE"'
Autor:
C. A. Lee, C. M. Kessler, D. Varon, U. Martinowitz, M. Heim, H. R. ROBERTS, D. M. MONROE, J. A. OLIVER, J.-Y. CHANG, M. HOFFMAN
Publikováno v:
Haemophilia. 4:331-334
Summary. In this report we describe an in vitro model of blood coagulation reactions that mimics as closely as possible the in vivo condition. Our model indicates that the tissue factor—factor VIIa complex initiates coagulation by activating small
Autor:
M, Hoffman, D M, Monroe
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 16
Our group has been studying how haemostasis interacts with repair processes and also how to optimize treatment of bleeding disorders in a mouse model of haemophilia B. We have found that cutaneous wounds heal more slowly in haemophilic mice than in w
Publikováno v:
Blood. 79:398-405
To study the requirements for factor-IXa binding to platelets and factor-X activation, we examined the consequences of chemical modification (factor IXMOD) or enzymatic removal (factor IXDES) of gamma-carboxyglutamic acid (Gla) residues. In the prese
Publikováno v:
British journal of haematology. 114(1)
Clinical experience has shown that high doses of recombinant factor VIIa (rFVIIa) may ensure haemostasis in thrombocytopenic patients. We have used a cell-based model system to mimic thrombocytopenia and analyse the effect of rFVIIa. Lowering the pla
Publikováno v:
American journal of hematology. 65(1)
A small number of thromboembolic events, including deep venous thrombosis and myocardial infarction, have been reported in patients receiving IVIG. These events have primarily occurred in patients receiving high-dose IVIG and have been attributed to
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 9
The importance of activated factor VII (FVIIa) in coagulation initiated by tissue factor (TF) was illustrated by competition of active site-inhibited FVIIa (FFR-FVIIa; FVIIa treated with D-Phe-Phe-Arg-chloromethyl ketone) with FVIIa in various cell-b
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 9
We have used a cell-based model system to examine some aspects of coagulation. Unactivated platelets and tissue factor (TF)-bearing cells were mixed with plasma levels of zymogen factors IX (FIX), FVIII, FX, FV, and prothrombin, as well as coagulatio
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 9
High levels of recombinant activated factor VII (rFVIIa; NovoSeven, Novo Nordisk, Bagsvaerd, Denmark) have been found to be effective in providing haemostasis in haemophiliacs and in normal individuals with acquired inhibitors to factor VIII (FVIII)
Publikováno v:
Thrombosis and haemostasis. 80(4)
Factors VIIa, Xa, and IXa play different roles in the initiation of tissue factor-dependent coagulation. The consequences of competing with the different enzymes were investigated, thereby examining the effects of inhibiting the initiation process at
Publikováno v:
Thrombosis and haemostasis. 79(2)
Tissue factor pathway inhibitor (TFPI) acts to regulate the initiation of coagulation by first inhibiting factor Xa. The complex of factor Xa/TFPI then inhibits the factor VIIa/tissue factor complex. The cDNA sequences of TFPI from several different