Zobrazeno 1 - 10
of 87
pro vyhledávání: '"D. M. Kochhar"'
Autor:
Jian Zhou, D. M. Kochhar
Publikováno v:
Reproductive Toxicology. 19:103-110
The question of how alterations in cell behavior produced by retinoic acid (RA) influenced the development of skeletogenic mesenchyme of the limb bud was examined in this study. Our established model was employed, which involves treatment of pregnant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32873fb89020099f893ae953b4c1aae
https://doi.org/10.1016/j.reprotox.2004.06.012
https://doi.org/10.1016/j.reprotox.2004.06.012
Publikováno v:
Teratology. 66:224-234
Background Phocomelia, which is primarily due to a disruption in the proximodistal axis, is found in virtually all mouse embryos exposed to high doses of retinoic acid (RA) on 11 days post coitum (dpc). Methods To identify genes that potentially medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fc5bc6d1b267eb5b1e75e42ed59cfb
https://doi.org/10.1002/tera.10082
https://doi.org/10.1002/tera.10082
Autor:
Kenneth J. Soprano, Roshantha A.S. Chandraratna, Jerome L. Gabriel, Sabina N. Sheikh, Carlo J. Gambone, Dianne Robert Soprano, D. M. Kochhar
Publikováno v:
Toxicology and Applied Pharmacology. 174:153-159
The synthetic retinoid AGN 193109 is a potent pan retinoic acid receptor (RAR) antagonist. Treatment of pregnant mice with a single oral 1 mg/kg dose of this antagonist on day 8 postcoitum results in severe craniofacial (median cleft face or frontona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548cc7755c91ccc82de591372b5a4075
https://doi.org/10.1006/taap.2001.9209
https://doi.org/10.1006/taap.2001.9209
Autor:
Mason Barr, Andrew G Hendrickx, William J. Scott, Thomas H. Shepard, Robert L. Brent, Godfrey P. Oakley, D. M. Kochhar
Publikováno v:
Teratology. 62:301-316
Background: The 39-year history of the Teratology Society is reviewed. An abbreviated history is outlined in table form, along with listings of the Warkany Lectures, the postgraduate courses, and officers of the Society. Methods: A year-by-year descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e8ac6bfccbfa4a5a227a6c32baf220
https://doi.org/10.1002/1096-9926(200011)62:5<301::aid-tera4>3.0.co
https://doi.org/10.1002/1096-9926(200011)62:5<301::aid-tera4>3.0.co
Publikováno v:
Chemico-Biological Interactions. 100:1-12
Early events that initiate teratogenesis by Accutane or other retinoids in mammalian embryos remain unknown. It would be helpful for mechanistic considerations to know whether or not retinoids act through retinoid receptor-dependent pathways, and if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23898f0aae27d3413ef3bc11509f20e0
https://doi.org/10.1016/0009-2797(95)03681-4
https://doi.org/10.1016/0009-2797(95)03681-4
Autor:
D. M. Kochhar
Publikováno v:
Congenital Anomalies. 35:55-71
There is overwhelming evidence that vitamin A (retinol), presumably through its metabolite retinoic acid, participates in organogenesis at several stages and sites during normal development. Besides the important role of retinol and retinoic acid (RA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e82e305491aec1a38ac57b5cb8866046
https://doi.org/10.1111/j.1741-4520.1995.tb00300.x
https://doi.org/10.1111/j.1741-4520.1995.tb00300.x
Autor:
Michael Gyda, D. M. Kochhar, Dianne Robert Soprano, Kenneth J. Soprano, Roshantha A.S. Chandraratna, Heng Jiang, Douglas C. Harnish
Publikováno v:
Teratology. 50:38-43
Retinoic acid (RA) plays an important role during normal embryogenesis, however high doses of RA are teratogenic. Retinoic acid receptor-beta 2 (RAR-beta 2) mRNA and protein levels were previously demonstrated to undergo rapid elevation in susceptibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8f12e16488c52a7903cf10fed1b976
https://doi.org/10.1002/tera.1420500106
https://doi.org/10.1002/tera.1420500106
Autor:
Michael A. Satre, Heng Jiang, Douglas C. Harnish, D. M. Kochhar, Michael Gyda, Kenneth E. Ugen, Lan X. Chen, Dianne Robert Soprano, Kenneth J. Soprano
Publikováno v:
Mechanisms of Development. 45:243-253
We have previously shown that oral treatment of pregnant mice with all-trans retinoic acid (RA) at doses which cause 100% fetal dysmorphogenesis results in a rapid elevation in the mRNA of one specific isoform of the RA receptor-beta, RAR-beta 2, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463f2472984b82f471805037f35ae5c3
https://doi.org/10.1016/0925-4773(94)90011-6
https://doi.org/10.1016/0925-4773(94)90011-6
Autor:
Michael Gyda, Dianne Robert Soprano, H. Jiang, D.C. Harnish, Kenneth J. Soprano, D. M. Kochhar, Nikolaos Tairis
Publikováno v:
Toxicology and Applied Pharmacology. 122:159-163
Vitamin A (retinol), its metabolite all-trans retinoic acid (RA), and many synthetic analogs (retinoids) express variable potencies as teratogens. Although biological activities of retinoids are mediated by nuclear RA receptors (RARs) and retinoid X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894f6ada2e5d908b3aea27d502aa9a10
https://doi.org/10.1006/taap.1993.1183
https://doi.org/10.1006/taap.1993.1183
Autor:
D. M. Kochhar, Peter J.A. Davies, Roshantha A.S. Chandraratna, Diana F. Colon, Richard L. Beard, Tae K. Song
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::571a2c095b80231bd8ad2d4b31c351d9
https://doi.org/10.1002/chin.199652160
https://doi.org/10.1002/chin.199652160